Low-dose topical 5-aminolevulinic acid photodynamic therapy in the treatment of different severity of acne vulgaris

Ma, Li; Xiang, Leihong; Yu, Bo; Yin, Rui; Chen, Lei; Wu, Yan; Tan, Zhijian; Liu, Yongbin; Tian, Haijun; Li, Huizhong; Lin, Tong; Wang, Xiuli; Li, Yuanhong; Wang, Wei-Zheng; Yang, Haowen; Wei, Lai

doi:10.1016/j.pdpdt.2013.06.007

Cited by 61 publications

(30 citation statements)

References 34 publications

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“…The average number of treatments for complete clearance was five (5.22) and some of the patients showing partial clearance are still under treatment. However, of those treated, none reported any pain, burning or discomfort during the illumination period, in contrast to other local photodynamic anti-infective approaches: for example, the treatment of acne vulgaris using aminolaevulinic acid [7]. Patients in the present cohort had generally tried to cure their infections previously using conventional antifungal agents, such as ketoconazole or terbinafine.…”

Section: Resultsmentioning

confidence: 92%

Small scale trial of photodynamic treatment of onychomycosis in São Paulo

Tardivo

Wainwright

Baptista

2015

Journal of Photochemistry and Photobiology B: Biology

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Section: Resultsmentioning

confidence: 92%

Small scale trial of photodynamic treatment of onychomycosis in São Paulo

Tardivo

Wainwright

Baptista

2015

Journal of Photochemistry and Photobiology B: Biology

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“…[11][12][13] ALA is a prodrug of porphyrins and widely used in topical PDT around the world. [14][15][16] However, the insufficient local bioavailability can limit the effectiveness of ALA-PDT. Lee et al showed that insoluble PpIX encapsulated in chitosan NPs had excellent photodynamic activity and were able to effectively induce the regression of skin tumors in mice.…”

Section: Discussionmentioning

confidence: 99%

Treating cutaneous squamous cell carcinoma using 5-aminolevulinic acid polylactic-co-glycolic acid nanoparticle-mediated photodynamic therapy in a mouse model

Wang¹,

Shi²,

Tu³

et al. 2015

IJN

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Background Squamous cell carcinoma (SCC) is a common skin cancer, and its treatment is still difficult. The aim of this study was to evaluate the effectiveness of nanoparticle (NP)-assisted 5-aminolevulinic acid (ALA) delivery for topical photodynamic therapy (PDT) of cutaneous SCC. Materials and methods Ultraviolet-induced cutaneous SCCs were established in hairless mice. ALA-loaded polylactic-co-glycolic acid (PLGA) NPs were prepared and characterized. The kinetics of ALA PLGA NP-induced protoporphyrin IX fluorescence in SCCs, therapeutic efficacy of ALA NP-mediated PDT, and immune responses were examined. Results PLGA NPs enhanced protoporphyrin IX production in SCC. ALA PLGA NP-mediated topical PDT was more effective than free ALA of the same concentration in treating cutaneous SCC. Conclusion PLGA NPs provide a promising strategy for delivering ALA in topical PDT of cutaneous SCC.

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“…18 Current clinical research of ALA is focused on its application in the treatment of genital warts, in°ammatory acne vulgaris and actinic keratosis in China. [19][20][21][22] The hyperproliferating or in°ammatory cells, often present in malignancies and LP lesions, can selectively uptake ALA and convert them to PpIX, which shows red°uorescence under UV irradiation. The normal tissue and nonin°ammatory cells uptake little to no ALA and show weak or no red°uor-escence.…”

Section: Discussionmentioning

confidence: 99%

Treatment of cutaneous lichen planus with ALA-mediated topical photodynamic therapy

Fan

Zhang

Wang

et al. 2015

J. Innov. Opt. Health Sci.

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Purpose: To evaluate the e®ectiveness of topical 5-aminolevulinic acid (ALA)-mediated photodynamic therapy (PDT) for the treatment of cutaneous lichen planus (LP). Methods: A total of 17 symptomatic LP lesions in 7 Chinese patients were assessed. ALA cream (10%) was applied topically to LP lesions for 3 h. The lesions were irradiated with a 635 nm diode laser at the dose level of 100 J/cm 2 . The treatment was repeated at two-week intervals. Clinical assessment was conducted before each treatment. Follow-up was performed once a month for up to six months. Results: Lesions showed signi¯cant improvement after one to four courses of treatments. Complete response was achieved in 13 lesions (¯ve patients) and partial remission in four lesions (two patients). The complete response rate was 71%. There was no signi¯cant side e®ects except the feeling of pain that most patients could tolerate. Follow-up of¯ve patients who achieved complete response showed no signs of recurrence. Conclusion: Topical ALA PDT is e®ective in the treatment of cutaneous LP.

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Low-dose topical 5-aminolevulinic acid photodynamic therapy in the treatment of different severity of acne vulgaris

Cited by 61 publications

References 34 publications

Small scale trial of photodynamic treatment of onychomycosis in São Paulo

Small scale trial of photodynamic treatment of onychomycosis in São Paulo

Treating cutaneous squamous cell carcinoma using 5-aminolevulinic acid polylactic-co-glycolic acid nanoparticle-mediated photodynamic therapy in a mouse model

Treatment of cutaneous lichen planus with ALA-mediated topical photodynamic therapy

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