Low Dose Treatment of RhTGF-β1 Restore the Wound Healing Defect in Dexamethasone-treated Rats

Kang, Ki Young; Kim, Hyun

doi:10.11637/kjpa.2010.23.4.207

Cited by 1 publication

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“…TGF-β1 also stimulates endothelial blood vessel cells, thereby promoting formation of blood vessels 6 , 7 ) . Therefore, TGF-β1 plays the most vital role in the proliferation and remodeling phases 8 ) .…”

Section: Introductionmentioning

confidence: 99%

Effects of high voltage pulsed current stimulation with a visible contraction intensity on expression of TGF-β1 and synthesis of type I collagen in wound-induced white rats

2015

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[Purpose] This study aimed to examine the expression of transforming growth factor β1 (TGF-β1) and type I collagen by applying high voltage pulsed current stimulation (HVPCS) with a visible contraction intensity to white rats with induced wounds. [Subjects] Thirty-six white rats were used for this study. HVPCS with a non-visible contraction intensity was applied to experimental group I, and HVPCS with a visible contraction intensity was applied to experimental group II. Placebo stimulation was applied to the control group. [Methods] After wounds were triggered, the intervention appropriate for each group was applied. Changes in the size of their wounds and expression of TGF- β1 and type I collagen were measured on the third, fifth, and seventh days. [Results] Comparison of the sizes of the wounds among the groups showed that the most significant decreases were found in experimental group II on the fifth and seventh days. TGF-β1 expression comparison revealed that experimental group II had the most expression on the fifth day. [Conclusion] HVPCS with a visible contraction intensity was effective in promoting wound healing by increasing expression of TGF-β1 and synthesis of type I collagen.

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Section: Introductionmentioning

confidence: 99%