Low doses of ionizing radiation activate endothelial cells and induce angiogenesis in peritumoral tissues

Marques, Filipa Gil; Poli, E.; Malaquias, João; Carvalho, Tânia; Portêlo, Ana; Ramires, Afonso; Aldeia, Fernando; Ribeiro, Ruy M.; Vitorino, Emília; Diegues, Isabel; Costa, Luís; Coutinho, João; Pina, Maria de Fátima de; Mareel, Marc; Santos, Susana Constantino Rosa

doi:10.1016/j.radonc.2019.06.035

Cited by 12 publications

(9 citation statements)

References 14 publications

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“…In vivo, LDIR significantly promote adult angiogenesis in the murine Matrigel assay and improved blood circulation, increased microvasculature and arteriogenesis in a hindlimb ischemia experimental model 10,11 . In human, we validated that endothelial cells were activated and vessel density increased by LDIR in biopsies from tissues exposed to these LDIR 26 .…”

Section: Discussionmentioning

confidence: 76%

“…Since we showed that doses lower or equal to 0.8 Gy induce angiogenesis both in vitro 11 , in different animal models 10,11 and in human 26 , we decided to consider this dose range and investigate the effect of doses lower or higher than 0.5 Gy in the zebrafish post-embryonic development. With the aim to investigate the effect of doses lower and higher than 0.5, Fli1:EGFP zebrafish larvae were exposed or not to 0.3 or 0.8 Gy, during three consecutive days and photographed over time.…”

Section: Ldir Significantly Increase the Expression Of Several Pro-anmentioning

confidence: 99%

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Low doses of ionizing radiation enhance angiogenesis and consequently accelerate post-embryonic development but not regeneration in zebrafish

Marques

Carvalho

Sousa

et al. 2020

Sci Rep

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Low doses of ionizing radiation (LDIR) activate endothelial cells inducing angiogenesis. In zebrafish,LDiR induce vessel formation in the sub-intestinal vessels during post-embryonic development and enhance the inter-ray vessel density in adult fin regeneration. Since angiogenesis is a crucial process involved in both post-embryonic development and regeneration, herein we aimed to understand whether LDiR accelerate these physiological conditions. our data show that LDiR upregulate the gene expression of several pro-angiogenic molecules, such as flt1, kdr, angpt2a, tgfb2, fgf2 and cyr61in sorted endothelial cells from zebrafish larvae and this effect was abrogated by using a vascular endothelial growth factor receptor (VEGFR)-2 tyrosine kinase inhibitor. Irradiated zebrafish present normal indicators of developmental progress but, importantly LDiR accelerate post-embryonic development in a VEGFR-2 dependent signaling. Furthermore, our data show that LDIR do not accelerate regeneration after caudal fin amputation and the gene expression of the early stages markers of regeneration are not modulated by LDiR. even though regeneration is considered as a recapitulation of embryonic development and LDIR induce angiogenesis in both conditions, our findings show that LDiR accelerate post-embryonic development but not regeneration. this highlights the importance of the physiological context for a specific phenotype promoted by LDIR.

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Section: Discussionmentioning

confidence: 76%

Section: Ldir Significantly Increase the Expression Of Several Pro-anmentioning

confidence: 99%

Low doses of ionizing radiation enhance angiogenesis and consequently accelerate post-embryonic development but not regeneration in zebrafish

Marques

Carvalho

Sousa

et al. 2020

Sci Rep

Self Cite

View full text Add to dashboard Cite

show abstract

“…What’s more, synergistic effect of SBRT can be observed in targeted therapy and immunotherapy by multiple mechanisms. Generally, repeated radiotherapy would in turn causes radioresistance in the tumor ( 26 , 27 ). In this regard, targeted therapies are employed to modulate tumor cells and angiogenesis as well as promote ceramide-mediated cell apoptosis to create a radiosensitive microenvironment ( 28 , 29 ).…”

Section: Discussionmentioning

confidence: 99%

Hepatocellular carcinoma complicated with huge posterior pancreas head lymph node metastasis and primary renal carcinoma: A case report

et al. 2022

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The incidence of hepatocellular carcinoma (HCC) associated with extrahepatic primary malignancy (EHPM) is extremely rare, especially for those that involve primary renal cell carcinoma (PRC). Here we present a case of a 66-year-old male who was diagnosed with HCC complicated with lymph node metastasis at posterior pancreas head and PRC. Biopsy results of the liver and the lymph node confirmed the diagnosis of HCC. The disease progressions of both HCC and PRC are controlled effectively following the initiation of comprehensive therapy including pembrolizumab, lenvatinib, radiotherapy, and transcatheter arterial chemo-embolization (TACE). Ultimately, the patient had successfully access to surgery and complete response (CR) of all the tumors were achieved after surgery.

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“…The results were considered as statistically significant when adjusted p-value < 0.05. K-means and hierarchical clustering were executed using "Factoextra" (1.0.5) [96], "dendextend" (1.9.0) [97], "colorspace" (1.3-2) [98], and "ggplot2" (2.2.1) [99].…”

Section: Multiple Myeloma (Mm) As a Paradigm For Endothelial Gatekeeper Function Within The Neoplastic Niche: In Silico Functional Enrichmentioning

confidence: 99%

Cancer-Associated Angiogenesis: The Endothelial Cell as a Checkpoint for Immunological Patrolling

Solimando

Summa

Vacca

et al. 2020

Cancers

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Cancer-associated neo vessels’ formation acts as a gatekeeper that orchestrates the entrance and egress of patrolling immune cells within the tumor milieu. This is achieved, in part, via the directed chemokines’ expression and cell adhesion molecules on the endothelial cell surface that attract and retain circulating leukocytes. The crosstalk between adaptive immune cells and the cancer endothelium is thus essential for tumor immune surveillance and the success of immune-based therapies that harness immune cells to kill tumor cells. This review will focus on the biology of the endothelium and will explore the vascular-specific molecular mediators that control the recruitment, retention, and trafficking of immune cells that are essential for effective antitumor immunity. The literature revision will also explore how abnormalities in the tumor endothelium impair crosstalk with adaptive immune cells and how targeting these abnormalities can improve the success of immune-based therapies for different malignancies, with a particular focus on the paradigmatic example represented by multiple myeloma. We also generated and provide two original bio-informatic analyses, in order to sketch the physiopathology underlying the endothelial–neoplastic interactions in an easier manner, feeding into a vicious cycle propagating disease progression and highlighting novel pathways that might be exploited therapeutically.

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Low doses of ionizing radiation activate endothelial cells and induce angiogenesis in peritumoral tissues

Cited by 12 publications

References 14 publications

Low doses of ionizing radiation enhance angiogenesis and consequently accelerate post-embryonic development but not regeneration in zebrafish

Low doses of ionizing radiation enhance angiogenesis and consequently accelerate post-embryonic development but not regeneration in zebrafish

Hepatocellular carcinoma complicated with huge posterior pancreas head lymph node metastasis and primary renal carcinoma: A case report

Cancer-Associated Angiogenesis: The Endothelial Cell as a Checkpoint for Immunological Patrolling

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