Low Doses of Long-chain Polyunsaturated Fatty Acids Affect Cognitive Function in Elderly Japanese Men: A Randomized Controlled Trial

Long-chain Polyunsaturated Fatty Acid Supplementation Improves Mood in Elderly Japanese Men

“…The secondary outcomes were mood assessed by POMS, LCPUFA DHA, EPA, and ARA content in plasma phospholipids, and dietary LCPUFA DHA, EPA, and ARA intake. A safety assessment was also performed, and it was previously reported that LCPUFA supplementation in the present study was considered safe under the conditions described here 22 .…”

“…This study was designed to evaluate the effects of LCPUFA supplementation on cognitive function in elderly Japanese men. The details of the participants and the study design, including inclusion and exclusion criteria for enrollment in this study, were described previously 22 . In brief, the participants were Japanese males aged 55-64 years without dementia or depression.…”

“…As described previously 22 , the enrolled participants were assigned in a 1:1 ratio to one of the two masked supplements, placebo or LCPUFA, based on a random number table. The randomization codes for these participants and the codes for the masked supplements were held by two different people not involved in this study, and information regarding these assignments was masked to researchers until all data were collected and analyzed.…”

“…The primary outcomes of this RCT have been described previously 22 . In brief, the primary outcome of this study was cognitive processing speed evaluated by event-related potential P300.…”

“…The objective of this study was to evaluate the effects of LCPUFA supplementation on mood in cognitively and emotionally normal elderly people. Previously, we conducted a randomized controlled trial RCT to evaluate the efficacy of LCPUFA 300 mg/day DHA, 100 mg/day EPA, and 120 mg/ day ARA on cognitive function in Japanese elderly men 22 .…”