Low energy Helium-Neon laser in the prevention of oral mucositis in patients undergoing bone marrow transplant: Results of a double blind randomized trial

A prospective, randomized study of cryotherapy during administration of high-dose melphalan to decrease the severity and duration of oral mucositis in patients with multiple myeloma undergoing autologous peripheral blood stem cell transplantation

“…Lasers appear to have an analgesic effect and may promote wound healing, but the precise cellular mechanisms of action are not clear. 7,15 Amifostine, a thiol-based cytoprotective agent, has been shown to reduce mucositis associated with high-dose melphalan. 8 Amifostine-treated patients had a reduction in the overall incidence of mucositis and less frequent severe mucositis.…”

“…6 The only approved agent for prevention of mucositis associated with high-dose therapy is palifermin, but several studies have shown that low-energy lasers or amifostine can reduce the incidence and severity of mucositis. 7,8 Additionally, there have been several reports of reduced oral mucositis in patients who kept ice chips in their mouth during infusional chemotherapy. 9,10 The scientific rationale for this approach is that cryotherapy leads to vasoconstriction and decreased blood flow to the oral cavity, which reduces the exposure of the buccal mucosa to chemotherapy.…”

Prophylaxis and treatment of chemo- and radiotherapy-induced oral mucositis – are there new strategies?

“…Topical laser irradiation 100,101 and brushing of the oral mucosa with silver-nitrate 102,103 seem to be promising for prophylaxis of oral complication after chemotherapy. Silver 126 34 G-CSF 5 g/kg rd CT ϩ (P = 0.07) BMT = bone marrow transplantation; co = cross-over; CT = chemotherapy; hc = historical control; HD-CT = high-dose chemotherapy; om = oral mucositis; nrd = non-randomised; nc = no control; PBSCT = peripheral blood stem cell transplantation; r = randomised; RT = radiotherapy; SCT = stem cell transplantation; NA =data not available.…”

Tratamento da mucosite em pacientes submetidos a transplante de medula óssea: uma revisão sistemática

“…The Helium -Neon Laser (He-Ne) 60mW is a current topical therapy that was assessed by a study that compared its action in parts of the mucosa in relation to the contralateral area, where a reduction on the mucositis seriousness was observed, on the 6th and 9th days after the transplant (23) . Another study also verified this therapy beneficial effects, however, the methodology did not adopt a control group comparison (24) . Palifermin is a human recombinant keratinocyte growth factor, a trial (25) revealed it reduces the incidence of degrees III and IV, while also reducing the febrile ... continuation neutropenia, and infection incidence, as well as parenteral nutrition use.…”