Low expression of B‐cell‐associated protein 31 in human primary hepatocellular carcinoma correlates with poor prognosis

Tan, Nguan Soon; Liu, Qinyi; Liu, Xiaojia; Gong, Zhiwei; Zeng, Yonglian; Pan, Guangdong; Xu, Qing; He, Songqing

doi:10.1111/his.12738

Cited by 34 publications

(29 citation statements)

References 23 publications

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“…Increasing evidence shows that BAP31, which serves as a novel cancer antigen, is highly expressed in many types of carcinoma. Notably, BAP31 has been found to aid in the proliferation and metastasis of tumors, and its aberrant expression correlates with poor prognosis in patients . The Oncomine datasets showed that the expression level of BAP31 in human gastric intestinal‐type adenocarcinoma is significantly higher than that in the normal gastric mucosa, suggesting that BAP31 might be a tumor‐associated antigen of GC.…”

Section: Discussionmentioning

confidence: 99%

“…Notably, BAP31 has been found to aid in the proliferation and metastasis of tumors, and its aberrant expression correlates with poor prognosis in patients. [11][12][13]34 The Oncomine datasets showed that the expression level of BAP31 in human gastric intestinal-type adenocarcinoma is significantly higher than that in the normal gastric mucosa, suggesting that BAP31 might be a tumor-associated antigen of GC. By analyzing the relationship of BAP31 with different tumor-associated antigens, we found that BAP31 could apparently affect the expression level of p27 kip1 .…”

Section: Discussionmentioning

confidence: 99%

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A BAP31 intrabody induces gastric cancer cell death by inhibiting p27^kip1 proteasome degradation

Chen

Guo

Jiang³

et al. 2019

Intl Journal of Cancer

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B‐cell receptor‐associated protein 31 (BAP31) is a ubiquitously expressed endoplasmic reticulum (ER) membrane protein that has been found to be overexpressed in gastric intestinal‐type adenocarcinoma. We first studied the relationship of BAP31 with 84 kinds of tumor‐associated antigens and found that BAP31 can specifically interact with and regulate the proteasome degradation of the cyclin kinase inhibitor p27kip1, which is one of the most frequently dysregulated tumor suppressor proteins in human cancers. Therefore, we screened antibodies against BAP31 from a human VH single‐domain antibody library and expressed the antibodies intracellularly. It was found that one of the intrabodies (VH‐D1) specifically inhibited p27kip1 proteasome degradation, possibly by blocking the combination of BAP31 with p27kip1. VH‐D1 displayed therapeutic effects, as it was able to reduce the growth of human gastric cancer (GC) cell xenografts in nude mice. This effect was due to inhibition of the proliferation and subsequent activation of caspase‐dependent apoptosis. Thus, BAP31 is a potential target for the suppression of GC via an intrabody‐based approach.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

A BAP31 intrabody induces gastric cancer cell death by inhibiting p27^kip1 proteasome degradation

Chen

Guo

Jiang³

et al. 2019

Intl Journal of Cancer

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“…The score of staining extent was 1 (<25%), 2 (25%-50%), 3 (51%-75%), and 4 (>75%). The final GSTA1 expression score was calculated with the intensity score × extent score, ranging from 0 to 12 16 . The staining results were divided into 3 categories based on the sum of scores: 0-3 was low GSTA1 group, 4-8 was moderate GSTA1 group, 9-12 was high GSTA1 group.…”

Section: Tma and Immunohistochemistrymentioning

confidence: 99%

Glutathione S-transferase A1 suppresses tumor progression and indicates better prognosis of human primary hepatocellular carcinoma

Liu¹,

Sui²,

Zhang³

et al. 2020

J. Cancer

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Glutathione S-transferase (GST) family members play an important role in detoxification, metabolism and carcinogenesis. The aim of this study is to investigate the effect of Glutathione S-transferase A1 (GSTA1) on the prognosis of HCC and to understand its role in tumor progression and the possible mechanism. GSTA1 in HCC was assessed using immunohistochemical staining, and it was found that HCC patients with better pathological differentiation had higher GSTA1 abundance. Further, high GSTA1 expression was correlated with low AFP, absent PVTT, and early stage TNM for HCC patients. Higher GSTA1 indicated longer overall survival and disease-free survival, while lower GSTA1 indicated poorer prognosis. Subsequently, lentiviral vector carrying GSTA1 gene was successfully constructed and maintained high expression in 97H and SNU449 liver cancer cells. We found that high GSTA1 restrained liver cancer cell proliferation, migration and invasion in vitro. Western blot showed that LKB1 and p-AMPK were upregulated while p-mTOR, p-p70 S6 Kinase and MMP-9 were downregulated in high GSTA1 groups. Taken together, high GSTA1 correlated with satisfactory prognosis of HCC. Additionally, GSTA1 may act as a protective factor through suppression of tumorigenesis by targeting AMPK/mTOR in HCC.

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“…ERC103, QuantiCyto, NeoBioscience, China). Integrated optical density (IOD) measurements were used to determine the positive‐staining density as previously reported . The IOD in each image was measured and calculated using the Beer–Lambert law.…”

Section: Methodsmentioning

confidence: 99%

Electrospun Heparin‐Loaded Core–Shell Nanofiber Sutures for Achilles Tendon Regeneration In Vivo

Zhou

Jing

et al. 2018

Macromolecular Bioscience

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Achilles tendon reconstruction surgery is the primary clinical method for repairing acute Achilles tendon ruptures. However, the efficacy of the postoperative healing process and the recovery of physiological function are inadequate. This study examines the healing mechanism of ruptured rat Achilles tendons seamed with heparin-loaded core-shell fiber sutures fabricated via near-field electrospinning. High-heparin-concentration sutures (PPH3.0) perform better than the low-heparin-concentration sutures and commercial sutures (CSs). The PPH3.0 suture recruits fewer inflammatory cells and shows good histocompatibility in peritoneal implantation experiments. Staining of the Achilles tendon rupture repair zone demonstrates that a high heparin concentration in sutures reduces immune-inflammatory responses. Immunohistochemical analysis reveals that the transforming growth factor-β staining scores of the PPH3.0 sutures are not significantly different from those of the corresponding control group but are significantly different from those of the CSs and non-heparin-loaded-suture groups. According to vascular endothelial growth factor (VEGF) analysis, the concentration of VEGF in the group treated with the PPH3.0 suture increases by 37.5% compared with that in its control group. No significant difference in tension strength is observed between the PPH3.0 group and healthy Achilles tendons. These findings illustrate that this novel method effectively treats Achilles tendon rupture and promotes healing and regeneration.

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Low expression of B‐cell‐associated protein 31 in human primary hepatocellular carcinoma correlates with poor prognosis

Abstract: BAP31 expression is an independent prognostic factor for OS of patients with postoperative HCC, and low expression levels of BAP31 in HCC may indicate poor outcomes of HCC patient after surgical resection.

Cited by 34 publications

References 23 publications

A BAP31 intrabody induces gastric cancer cell death by inhibiting p27^kip1 proteasome degradation

A BAP31 intrabody induces gastric cancer cell death by inhibiting p27^kip1 proteasome degradation

Glutathione S-transferase A1 suppresses tumor progression and indicates better prognosis of human primary hepatocellular carcinoma

Electrospun Heparin‐Loaded Core–Shell Nanofiber Sutures for Achilles Tendon Regeneration In Vivo

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Low expression of B‐cell‐associated protein 31 in human primary hepatocellular carcinoma correlates with poor prognosis

Abstract: BAP31 expression is an independent prognostic factor for OS of patients with postoperative HCC, and low expression levels of BAP31 in HCC may indicate poor outcomes of HCC patient after surgical resection.

Cited by 34 publications

References 23 publications

A BAP31 intrabody induces gastric cancer cell death by inhibiting p27kip1 proteasome degradation

A BAP31 intrabody induces gastric cancer cell death by inhibiting p27kip1 proteasome degradation

Glutathione S-transferase A1 suppresses tumor progression and indicates better prognosis of human primary hepatocellular carcinoma

Electrospun Heparin‐Loaded Core–Shell Nanofiber Sutures for Achilles Tendon Regeneration In Vivo

Contact Info

Product

Resources

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A BAP31 intrabody induces gastric cancer cell death by inhibiting p27^kip1 proteasome degradation

A BAP31 intrabody induces gastric cancer cell death by inhibiting p27^kip1 proteasome degradation