Low fasting plasma glucose level as a predictor of new-onset diabetes mellitus on a large cohort from a Japanese general population

Abstract

Although fasting plasma glucose levels <70 mg/dL are associated with a high incidence of cardiovascular disease (CVD), whether there is any risk of new-onset diabetes mellitus owing to fasting plasma glucose at this range has not been clarified. We measured the odds ratio (OR) of new-onset diabetes mellitus relative to fasting plasma glucose levels at various ranges in a nation-wide Japanese population with and without CVD history. Of 186,749 participants without diabetes in 2008, 171,408 had no history of CVD, while 15,341 did. Participants were classified into 8 categories according to their fasting plasma glucose levels. Unadjusted and multivariable-adjusted logistic regression models were used to measure the OR of new-onset diabetes mellitus in the 3-year follow up. In all participants, multivariable-adjusted OR increased when fasting plasma glucose levels were <70 mg/dL or 90–125 mg/dL. Participants without CVD showed increased OR when glucose levels were <70 mg/dL or 90–125 mg/dL. Participants with a history of CVD showed increased OR with glucose levels of 95–125 mg/dL. The risk of new-onset diabetes mellitus is higher when fasting glucose levels are <70 mg/dL, indicating that the paradox of fasting glucose seeks a new risk stratification for new-onset diabetes mellitus.

Fasting plasma glucose and risk of type 2 diabetes mellitus in a group of Chinese people with normoglycemia and without obesity

“…Similar to the previous reports, higher FPG levels are associated with future diabetes in different populations with normoglycemia. [1][2][3][4][5][6][7] Our study confirms and extends these findings in a group of healthy Chinese people with normoglycemia and without obesity. Therefore, higher FPG levels within the normoglycemic range could also help to identify nonobese subjects at increased risk for diabetes.…”

“…To the Editor Historical studies have shown that, even within normal fasting plasma glucose (FPG) level, higher FPG levels still carry a higher risk for type 2 diabetes mellitus (T2DM). [1][2][3][4][5][6][7] Meanwhile, there was still inconsistency in these studies, especially for individuals without obesity. 1 It is well known that obesity is a significant risk factor for T2DM.…”

Derivation and Validation of a Prediction Model for Predicting the 5-Year Incidence of Type 2 Diabetes in Non-Obese Adults: A Population-Based Cohort Study

“…Elevated FPG levels are associated with an increased risk of T2D, which may be closely related to insulin response and insulin sensitivity. 69 HbA1c level not only reflects the blood glucose level at a certain time point, but also reflects the average blood glucose level in the past three months. 70 Previous studies have shown that HbA1c can be used as a predictor of T2D, diabetic complications and diabetic drug response.…”

Association of MC4R (rs17782313) with diabetes and cardiovascular disease in Korean men and women

“…Diabetes is mainly assessed by the fasting blood-glucose level [1]. Several previous studies reported that the melanocortin-4 receptor (MC4R) (MIM 155541) gene is a candidate as a causal gene for type 2 diabetes [2,3].…”