2000
DOI: 10.1002/1098-2264(2000)9999:9999<::aid-gcc1038>3.0.co;2-c
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Low frequency of allelic imbalance at the prostate cancer susceptibility lociHPC1 and 1p36 in Swedish men with hereditary prostate cancer

Abstract: The aim of this study was to investigate allelic imbalance at the major human prostate cancer susceptibility locus HPC1 at 1q24–25 and the recently reported, putative, susceptibility locus at 1p36 in prostate tumors from Swedish families with hereditary prostate cancer. We analyzed 31 prostate tumors and two lymph node metastases from 33 Swedish men in 22 families with hereditary prostate cancer for the presence of allelic imbalance using microsatellite markers D1S158, D1S422, and D1S238 for the HPC1 locus and… Show more

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Cited by 16 publications
(5 citation statements)
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“…However, the effect of CAPB appears to be independent of the HPC1 locus (1q24-25) that has been confirmed in families with aggressive prostate cancer occurring at median age. Furthermore, very low levels of allelic imbalance found at HPC1 and 1p36 make it unlikely that these loci contain classic tumour suppressor genes (Ahman et al , 2000). Nevertheless, human chromosome 1p36 is recognised to be a fragile region, as evidenced by the Alu blocks identified in this study.…”
Section: Discussionmentioning
confidence: 99%
“…However, the effect of CAPB appears to be independent of the HPC1 locus (1q24-25) that has been confirmed in families with aggressive prostate cancer occurring at median age. Furthermore, very low levels of allelic imbalance found at HPC1 and 1p36 make it unlikely that these loci contain classic tumour suppressor genes (Ahman et al , 2000). Nevertheless, human chromosome 1p36 is recognised to be a fragile region, as evidenced by the Alu blocks identified in this study.…”
Section: Discussionmentioning
confidence: 99%
“…There has been a great interest in identifying genes located in this chromosomal region to get better understanding of the etiology of the associated diseases. Loss of heterozygosity in the 1p36 region has been associated with most neuroblastoma (Grenet et al, 1998;Hogarty et al, 2000;Ohira et al, 2000) but also lung cancer (Nomoto et al, 2000), breast carcinoma (Ejeskar et al, 2000) or prostate cancer (Ahman et al, 2000) etc. In particular, GEF720 gene is located in a 1 megabase consensus at 1p36.3 which is often deleted in primary neuroblastoma (Hogarty et al, 2000) and which also contains the two genes TNFRSF12/DR3/APO3 (Grenet et al, 1998) and TP73 (Kaghad et al, 1997).…”
Section: Discussionmentioning
confidence: 99%
“…Approximately 15-45% of prostate tumors were found to display MSI, and its incidence increased with the severity of the disease. In contrast, a few studies detected little or no MSI in prostate tumors [10][11][12][13][14]. This discrepancy may be due to differences in tissue isolation methods and inconsistencies in the number and type of MSI markers used to detect instability.…”
Section: Introductionmentioning
confidence: 99%