Low-GDP peritoneal dialysis fluid ('balance') has less impact in vitro and ex vivo on epithelial-to-mesenchymal transition (EMT) of mesothelial cells than a standard fluid

Bajo, María Auxiliadora; Pérez-Lozano, María Luisa; Albar-Vizcaíno, Patricia; Peso, Gloria del; Castro, Marcelo Peduzzi de; Gónzalez-Mateo, Guadalupe Tirma; Fernández-Perpén, A; Aguilera, Abelardo; Sánchez-Villanueva, Rafael; Sánchez-Tomero, José Antonio; López–Cabrera, Manuel; Peter, M.; Passlick–Deetjen, Jutta; Selgas, Rafael

doi:10.1093/ndt/gfq357

Cited by 80 publications

(78 citation statements)

References 27 publications

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“…Two among the final 12 studies were performed by Kim et al One showed the result at 12 months and the more recent study showed the result at 24 months with the same patients (28). Therefore, we applied the result only at 24 months, and the SR was conducted on the final 11 studies (1,034 patients) (21)(22)(23)(24)(25)(26)(27)(28)(29)(30)43,44) (Figure 1).…”

Section: Resultsmentioning

confidence: 99%

Effect of Biocompatible Peritoneal Dialysis Solution on Residual Renal Function: A Systematic Review of Randomized Controlled Trials

Seo

Cho

et al. 2014

Perit Dial Int

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♦ Introduction: Residual renal function (RRF) plays an important role in outcome of peritoneal dialysis (PD) including mortality. It is, therefore, important to provide a strategy for the preservation of RRF. The objective of this study was to evaluate relative protective effects of new glucose-based multicompartmental PD solution (PDS), which is well known to be more biocompatible than glucosebased conventional PDS, on RRF compared to conventional PDS by performing a systematic review (SR) of randomized controlled trials. ♦ Methods: We searched studies presented up to January 2014 in MEDLINE, EMBASE, the COCHRANE library, and local databases. Three independent reviewers reviewed and extracted prespecified data from each study. The random effects model, a more conservative analysis model, was used to combine trials and to perform stratified analyses based on the duration of follow-up. Study quality was assessed using the Cochrane Handbook for risk of bias. Eleven articles with 1,034 patients were identified for the SR.

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Section: Resultsmentioning

confidence: 99%

Effect of Biocompatible Peritoneal Dialysis Solution on Residual Renal Function: A Systematic Review of Randomized Controlled Trials

Seo

Cho

et al. 2014

Perit Dial Int

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“…The potential mechanisms whereby conventional dialysate might drive membrane injury are many and include nonphysiological pH (acidic, typically 5.2), lactate buffer, increased osmolality, high glucose concentrations, and high glucose degradation product (GDP) concentrations. The evidence that low GDP solutions are associated with preservation of mesothelium cells is reasonably compelling from biomarker studies, in particular the increase in dialysate CA-125 levels associated with the use of all the tested biocompatible solutions so far (35) and in one case evidence for reduced epithelial to mesenchymal transition in their morphologic appearance (36). However in our study when patients are compared in terms of biocompatibility of solutions high transporter number was high in conventional solution group but this difference was not statistically different.…”

Section: Discussionmentioning

confidence: 99%

Relationship between peritoneal permeability with inflammation and subclinical atherosclerosis in peritoneal dialysis patients

Yayar¹,

Eser²,

Bozkurt³

2017

J Turgut Ozal Med Cent

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Aim: High permeability in peritoneal dialysis (PD) is reported to be associated with increased mortality. Cardiovascular disease is the most important cause of morbidity and mortality in patients with end-stage renal disease. The inflammation is thought to take part in development of atherosclerosis. The aim of this study is to investigate the relation of peritoneal permeability type with carotid intima media thickness (CIMT) in PD patients. Material and Methods: Based on the standard peritoneal equilibration test, 56 PD patients (28 male) were divided in two transporter groups: low (low+low average) and high (high+high average) permeability. C-reactive protein (CRP) measured as a marker of inflammation and CIMT was evaluated by high-resolution B-mode ultrasonography. Results: Twenty one patients were low and 35 of them were high peritoneal transporters. Mean CRP level was significantly higher in the high permeability group (HPG) (1.62±1.7 vs 0.84±1 mg/dL; p=0.006). CIMT was higher in the HPG but this difference did not reach statistical significance (0.810±0.160 vs 0.740±0.160 mm; p=0.16). Conclusions: CRP, an indicator of inflammation, was found to be higher in the HPG. CIMT also was found to be higher in HPG although it was not statistically significant. One of the causes of increased mortality rate in this group of patients may be explained by inflammation and atherosclerosis.

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“…This results in damage to the peritoneum and alters the peritoneal structure and transportation function. Finally, peritoneal ultrafiltration failure occurs resulting in failure of PD (8). Peritoneal fibrosis is also one of the main causes of PD failure.…”

Section: Discussionmentioning

confidence: 99%

Long-term efficacy of intermittent peritoneal dialysis using various doses

Zhang

Zhou

et al. 2011

Experimental and Therapeutic Medicine

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Abstract. The objective of the present study was to investigate the long-term clinical efficacy of intermittent peritoneal dialysis (IPD) using various doses and to explore the most suitable dialysis dose and practice pattern for patients. A total of 52 inpatients/outpatients who had undergone IPD for more than 5 years were recruited and divided into three groups according to the dialysis dose: 4 liters in Group A, 6 liters in Group B and 8 liters in Group C. The dwell time was 4 h. All patients were fasted overnight. The dialysis adequacy, nutritional status, complication control, blood pressure and intra-abdominal infection were determined and observed among these patients. Barthel index (BI) and Hamilton Depression Scale (HAMD) were employed to measure the activities of daily living (ADL) and degree of depression, respectively. The dialysis adequacy and ultrafiltration volume in Group A were lower than those in Groups B and C, but the residual urine volume was larger than that in the latter two groups. In addition, there was a marked difference in the control of complications between Group A and Groups B and C. When compared to Groups A and B, the nutritional status in Group C was significantly decreased, the mean arterial pressure and intra-abdominal infection rates were dramatically increased, and the HAMD scores were also higher (P<0.05). No significant difference was noted in the BI. For patients undergoing long-term IPD, individualized dialysis dose may benefit the dialysis adequacy, nutritional status, control of complications, blood pressure, rate of intraabdominal infection, ADL and depression.

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Low-GDP peritoneal dialysis fluid ('balance') has less impact in vitro and ex vivo on epithelial-to-mesenchymal transition (EMT) of mesothelial cells than a standard fluid

Cited by 80 publications

References 27 publications

Effect of Biocompatible Peritoneal Dialysis Solution on Residual Renal Function: A Systematic Review of Randomized Controlled Trials

Effect of Biocompatible Peritoneal Dialysis Solution on Residual Renal Function: A Systematic Review of Randomized Controlled Trials

Relationship between peritoneal permeability with inflammation and subclinical atherosclerosis in peritoneal dialysis patients

Long-term efficacy of intermittent peritoneal dialysis using various doses

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