Low-grade extrauterine endometrial stromal sarcoma of the peritoneum: A case report and literature review

Gorostiaga, Iñigo; Perez-Rodriguez, Alvaro; Gómez-Mateo, M. Carmen; Cuadra-Cestafe, María; Sagasta, Amaia

doi:10.1016/j.patol.2020.06.009

Cited by 3 publications

(3 citation statements)

References 12 publications

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“…Postoperative chemotherapy [19] , radiotherapy [20] or hormone therapy may be used. Low-grade EESS is a hormonedependent low-grade malignant tumor with about 80% ER/PR expression [21] . For this reason, hormonal growth signals play a critical role in the development of this group of tumors [22] .…”

Section: Discussionmentioning

confidence: 99%

Primary extrauterine endometrial stromal sarcoma with multiple organ invasion: A case report

Xu,

Niu,

Zhou

et al. 2024

Preprint

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Background: Primary extrauterine endometrioid stromal sarcoma (EESS) are rarer tumors that occur outside the uterus and do not involve the uterus. Case presentation: We report a case of low-grade extrauterine endometrial stromal sarcoma of the pelvic and colorectum. A 46-year-old woman, who complained of diarrhea with yellow mucus-like or elongated stools for more than 2 months, came to our hospital with colonoscopy and CT results that raised suspicion of colorectal cancer but also pathological examination results indicative of endometriosis. As the intraoperative pathology of the omentum and ovary revealed endometrial stromal sarcoma, and part of the sigmoid and rectum were obviously thickened and stiff, we performed cytoreductive surgery including removal of the uterus, bilateral fallopian tubes, bilateral ovaries, part of the colorectum, omentum majus, and metastatic lesions. Postoperative pathology revealed that the pelvic mass and segments from the colorectum were consistent with low-grade endometrial stromal sarcoma. Long-term oral administration of Letrozole, 2.5mg/day and Farlutal, 500mg/day was prescribed. During follow-up of the patient, the pelvic peritoneal examination results were negative, and has remained disease-free at 48-months post-surgery. Conclusion: We report a rare case of simultaneous endometrial stromal sarcoma of the pelvic and colorectum.

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Section: Discussionmentioning

confidence: 99%

Primary extrauterine endometrial stromal sarcoma with multiple organ invasion: A case report

Xu,

Niu,

Zhou

et al. 2024

Preprint

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“…Las células tumorales son pequeñas con citoplasma ovalado a fusiforme y núcleos uniformes que se ubican alrededor de vasos sanguíneos pequeños similares a arteriolas. Esto está acompañado de placas hialinas, cambios quísticos, hemorragias y necrosis coagulativa (11) . Las células tumorales muestran fuerte positividad para vimentina y receptores hormonales (estrógeno y progesterona), mientras que son negativas para desmina, SMA y citoqueratina (12) .…”

Section: Discussionunclassified

“…La supervivencia a diez años en los estadios I y II es superior al 90% y disminuye hasta 66% en los estadios III y IV. Sin embargo, estos tumores, independientemente del estadio, tienen alta probabilidad de recidivas tardías y metástasis 10 a 15 años después del diagnóstico inicial y pueden tratarse con resección quirúrgica, radioterapia, progestágenos o terapias combinadas (11) . Es necesario el seguimiento prolongado, ya que casi un tercio de los casos presentan extensión pélvica extrauterina, más comúnmente al ovario, incluso en estadios iniciales (7) .…”

Section: Discussionunclassified

Sarcoma del estroma endometrial de bajo grado

Rondón-Tapía¹,

Torres-Cepeda²

2022

Rev peru ginecol obstet.

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El sarcoma del estroma endometrial es una neoplasia maligna poco frecuente que se origina en el estroma endometrial. Puede tener varias formas de diferenciación, entre ellas del músculo liso y del cordón sexual. El sarcoma del estroma endometrial de bajo grado es un tipo de tumor endometrial raro, que constituye solo el 0,2% de todas las neoplasias uterinas. Su etiología es desconocida, pero algunos casos se asocian con obesidad, síndrome de ovario poliquístico, diabetes mellitus, menarquia temprana y terapia de sustitución de estrógenos o al tamoxifeno. La sintomatología es inespecífica, varía desde el dolor pélvico hasta el sangrado genital anormal progresivo y es difícil de reconocer por las imágenes radiológicas. En la mayoría de los casos, el diagnóstico se realiza mediante una evaluación anatomopatológica. La tinción inmunohistoquímica también puede ayudar a diferenciarlo de otras neoplasias. Por lo tanto, es importante tener un alto índice de sospecha para este tipo de neoplasia rara. Su tratamiento es quirúrgico y su seguimiento debe ser a largo plazo, debido al alto riesgo de recidivas tardías y metástasis. Se presenta un caso de sarcoma estromal endometrial de bajo grado.

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Low Grade Extrauterine Endometrial Stromal Sarcoma Arising from Peritoneum Endometriosis: A Case Report and Literature Review

Haghighatkhah,

Ghasimi,

Moradi

et al. 2024

Int J Cancer Manag

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Introduction: Endometrial stromal sarcoma (ESS) is an uncommon condition that accounts for approximately 0.2% of all reproductive tract malignancies. Among the various subtypes of ESS, low-grade extrauterine endometrial stromal sarcoma (LG-EESS) is even rarer and has only been reported in a limited number of case studies. Case Presentation: We reported a case of LG-EESS in a 35-year-old woman with a five-year history of stage IV endometriosis. The patient presented with chronic abdominopelvic pain and dysmenorrhea. Transvaginal ultrasound showed bilateral tubo-ovarian complexes with multicystic structures, while MRI revealed solid lesions with T1 iso signal, T2 hypersignal, and diffusion restriction, indicating metastatic implantation extending to the peritoneum and subhepatic region. A core needle biopsy confirmed LG-EESS, and immunohistochemistry showed CD10 positivity, aiding in the diagnosis and distinguishing it from other tumors. Conclusions: Our case highlights the potential utility of preoperative diagnostic imaging, particularly MRI, in the evaluation of LG-EESS. Additionally, it emphasizes the importance of considering the possibility of extrauterine ESS, as this tumor exhibits histopathological features and clinical behavior similar to its uterine counterpart.

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Low-grade extrauterine endometrial stromal sarcoma of the peritoneum: A case report and literature review

Cited by 3 publications

References 12 publications

Primary extrauterine endometrial stromal sarcoma with multiple organ invasion: A case report

Primary extrauterine endometrial stromal sarcoma with multiple organ invasion: A case report

Sarcoma del estroma endometrial de bajo grado

Low Grade Extrauterine Endometrial Stromal Sarcoma Arising from Peritoneum Endometriosis: A Case Report and Literature Review

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