Low-grade fibromyxoid sarcoma involving the mandible: A diagnostic dilemma

Chaudhuri, Kanad; Kasimsetty, Chatura Ramakantha; Ashok, L; Gujjar, Pramod Vittobarao

doi:10.4103/0973-029x.185914

Cited by 11 publications

(3 citation statements)

References 14 publications

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“…Leiomyosarcomas stain with antibodies to SMA, desmin, and caldesmon [43], while embryonal rhabdomysarcoma shows positivity for MyoD and myogenin [44]. A summary of immunohistochemical stains that can be used to distinguish fibromyxoma is provided in Table 2 [40,[45][46][47][48][49][50][51][52][53][54].…”

Section: Differential Diagnosis: Histopathologymentioning

confidence: 99%

Fibromyxoma of the Jaw: Case Report and Review of the Literature

Alhousami

Sabharwal

Gupta

et al. 2017

Head and Neck Pathol

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We report a case of fibromyxoma of the mandible, a rare benign odontogenic tumor. Our patient presented in the first trimester of pregnancy with a large mass in the right body of the mandible exhibiting displacement of teeth and destruction of an extensive area of the mandibular bone. The mass was biopsied and diagnosed as a fibromyxoma. The large size of the tumor dictated a wide mandibular resection. We will review the clinical, radiographic, and histologic features of fibromyxoma and discuss its differential diagnoses. In addition, we will provide an overview of patient management. Fibromxyoma is a benign gnathic tumor that can be locally aggressive. To ensure appropriate treatment, it is important to distinguish this neoplasm from other mimickers in which myxoid, spindle mesenchymal cell proliferation is prominent.

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Section: Differential Diagnosis: Histopathologymentioning

confidence: 99%

Fibromyxoma of the Jaw: Case Report and Review of the Literature

Alhousami

Sabharwal

Gupta

et al. 2017

Head and Neck Pathol

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“…9 However, LGFMS involving the head and neck region is very rare with only 27 cases in the English literature to date ( Table 1 ). 3 4 5 6 10 11 12 13 14 15 16 17 18 19 20 21 22 Of these, only two cases have been found in the parotid gland. Botev et al reported a giant sarcoma of the parotid gland in a 57-year-old woman with histologic features consistent with LGFMS.…”

Section: Discussionmentioning

confidence: 99%

“…Summary of LGFMS cases in the head and neck region[3][4][5]7,[10][11][12][13][14][15][16][17][18][19][20][21][22][23][24]26 …”

mentioning

confidence: 99%

Low-Grade Fibromyxoid Sarcoma Featuring an Unusual EWSR1-CREB3L2 Gene Fusion: Report of a Rare Case Arising in the Parotid Gland

Alayed

Pharaon

2022

Avicenna J Med

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Low-grade fibromyxoid sarcoma (LGFMS), also known as Evan's tumor, is a fibroblastic tumor with a deceptively bland morphology but a high metastasizing potential and late recurrence. It presents clinically as a slowly growing mass in the deep soft tissue of extremities and trunk. Morphologically, it shows a biphasic pattern with alternating fibrous and myxoid areas, whorling growth pattern, hypocellularity, and bland fibroblasts with curvilinear or arcuate vessels in between. Collagen rosettes with central hyalinization is a helpful feature but not specific. MUC-4 is the most sensitive immunostain in LGFMS. The majority of cases harbor a gene fusion in FUS-CREB3L2. Herein, we present a 23-year-old female patient with a slow growing painless mass in the left parotid gland, which was later diagnosed as LGFMS. Involvement of the head and neck region by LGFMS is uncommonly encountered. To date, only two cases within the parotid gland have been described.

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Low-Grade Fibromyxoid Sarcomas with the Maxillary Sinus Localization: A Case Report and Review of the Literature

Doblan

2021

Indian J Otolaryngol Head Neck Surg

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A low-grade fibromyxoid sarcoma (LGFMS) is an extremely rare tumor first described by Evans in 1987.LGFMS is a type of soft tissue sarcoma characterized by a deceptively benign histological appearance but completely malignant behavior. LGFMS is usually seen in the deep soft tissues of the extremities and trunk. We have examined many reviews, case reports and case series previously published in PubMed and Google Scholar. To date, only five cases have been reported in the maxilla. LGFMS generally affects young adults, but it can also be seen in children and older adults. A radical surgical approach is the most recommended treatment option. LGFMS has a very low mitotic activity; therefore, it is considered that neither chemotherapy nor radiotherapy has a significant effect on long-term LGFMS prognosis. However, to date, there has been no study suggesting any protocol for the follow-up of patients with LGFMS. In this report, we present a case with LGFMS located in the maxillary sinus, in which despite radiotherapy following extensive surgical excision, the tumor recurred in a short period of three months and reached its former size.

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Low-grade fibromyxoid sarcoma involving the mandible: A diagnostic dilemma

Cited by 11 publications

References 14 publications

Fibromyxoma of the Jaw: Case Report and Review of the Literature

Fibromyxoma of the Jaw: Case Report and Review of the Literature

Low-Grade Fibromyxoid Sarcoma Featuring an Unusual EWSR1-CREB3L2 Gene Fusion: Report of a Rare Case Arising in the Parotid Gland

Low-Grade Fibromyxoid Sarcomas with the Maxillary Sinus Localization: A Case Report and Review of the Literature

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