Fibromyxoma of the Jaw: Case Report and Review of the Literature

Abstract

We report a case of fibromyxoma of the mandible, a rare benign odontogenic tumor. Our patient presented in the first trimester of pregnancy with a large mass in the right body of the mandible exhibiting displacement of teeth and destruction of an extensive area of the mandibular bone. The mass was biopsied and diagnosed as a fibromyxoma. The large size of the tumor dictated a wide mandibular resection. We will review the clinical, radiographic, and histologic features of fibromyxoma and discuss its differential diagnoses. In addition, we will provide an overview of patient management. Fibromxyoma is a benign gnathic tumor that can be locally aggressive. To ensure appropriate treatment, it is important to distinguish this neoplasm from other mimickers in which myxoid, spindle mesenchymal cell proliferation is prominent.

Rare Case of Tracheal Fibromyxoma in Obstructive Tracheal Mass

“…Given their rarity and subsequent low index of suspicion, there is often difficulty in making the initial diagnosis which can delay intervention. Fibromyxomas are a type of rare benign soft tissue tumor that are derived from mesenchyme and have been previously described on the skin, stomach, digits, and mandible [ 4 - 7 ]. To our knowledge there have only been two other reported primary tracheal fibromyxomas [ 8 , 9 ].…”

Odontogenic fibromyxoma: A case report in myasthenia gravis patient and review of the literature

“…When the literature was searched for the incidence of odontogenic fibromyxoma, no single incidence rate was found. Myxomas constitutes approximately 1–17.7 % of all odontogenic tumors and odontogenic fibromyxomas represent a very small part of all myxomas and their prevalence varies from 0.04 % to 3.7 % [1] , [2] , [3] , [4] , [5] , [6] , [7] , [8] , [9] , [10] , [11] , [12] , [13] , [14] , [15] , [16] , [17] , [18] , [19] , [20] .…”

“…It either mixes freely with the tissue from which it comes out or is separated by a pseudocapsule. Myxomas contain little collagen and unlike myxomas, fibromyxomas may show calcification or ossification and contain higher amounts of thick collagen fibers and vessels [7] , [9] , [10] , [12] , [13] , [17] , [18] , [19] . There is no difference in the biological behavior of myxomas and fibromyxomas [21] .…”

“…Odontogenic myxomas and fibromyxomas are classified as mesenchymal odontogenic tumors (with limited or without odontogenic epithelium) under the WHO classification of odontogenic neoplasms [11] , [12] , [13] . Previous theories show that the lesion derives from the neural sheath or is the result of degeneration of fibromas, lipomas, and; chronic irritation and the degenerative processes following tissue anoxemia [22] .…”

“…Recent studies are considered to originate from primitive mesenchymal structures and are thought to arise from bone, tooth germ, or odontogenic tissues such as dental papilla, dental follicle or periodontal ligament. For this reason, we can say that all myxomas seen in the jaws are of odontogenic origin [7] , [8] , [9] , [10] , [11] , [13] , [14] , [15] , [16] , [17] , [20] , [23] , [24] , [25] , [26] , [27] , [28] , [29] .…”