Low‐grade gangliogliomas in adults: A population‐based study

Abstract

Background Low‐grade gangliogliomas (GGs) are rare tumors of the central nervous system in adults. This study aims to define their characteristics, prognostic factors, and the impact of different treatment patterns on survival. Methods The Surveillance, Epidemiology, and End Results (SEER) database was used to investigate the potential clinicopathological factors of low‐grade GGs in adult patients (age ≥18 years). Kaplan–Meier method and Cox regression model were utilized to evaluate the associations between variables and overall survival (OS). Results A total of 703 adult patients diagnosed with low‐grade GGs were identified between 2004 and 2016, with a median follow‐up period of 60.0 months. The median age at diagnosis was 32.0 years, with 50.1% of patients being male, 84.2% white people, and 40.2% of married status. The predominant tumor site was located in temporal lobe (38.8%). The median OS time for the whole cohort was not reached. The 5‐ and 10‐year OS rates for patients underwent gross total resection (GTR) were 92.5% and 87.2%, respectively. Univariate and multivariate analysis showed age, gender, tumor site, and treatment pattern were significant factors for OS. The employment of adjuvant radiotherapy (RT) and/or chemotherapy would significantly shorten OS time. Conclusions This is the largest retrospective study of adult low‐grade GGs up to date. Younger age, female gender, temporal lobe location, and GTR indicated better survival. Adjuvant RT and/or chemotherapy should not be considered after whatever surgery in adult patients with low‐grade GGs, unless the malignant transformation has been confirmed.

Pineal region ganglioglioma: A neoplasm with a bimodal age distribution

“…We reviewed the literature and found 24 additional cases of ganglioglioma in the pineal region [ Table 1 ]. [ 3 - 7 , 9 - 10 , 13 - 16 , 19 , 21 - 22 , 24 , 31 , 33 , 37 - 38 , 40 ] Two cases that have historically been classified as pineal region gangliogliomas were not available for review and therefore not included in the analysis. [ 27 , 35 ] Fifteen case reports included data on patient age.…”

An imaging review of the hippocampus and its common pathologies

“…Because gangliogliomas typically behave in a nonaggressive manner, they are generally considered to be low-grade neoplasms. 61 MRI of gangliogliomas reveals well-circumscribed masses that are partially cystic. 62 On T1-weighted imaging, the solid components of these tumors appear iso-or hypointense.…”

Ganglioside Composition Distinguishes Anaplastic Ganglioglioma Tumor Tissue from Peritumoral Brain Tissue: Complementary Mass Spectrometry and Thin-Layer Chromatography Evidence

“…Ganglioglioma are benign (WHO grade I) [1] and rare well-differentiated and typically slow-growing mixed glioneuronal tumors composed of dysplastic mature ganglion cells and neoplastic glial cells with the highest incidence rates being in children and young adults, but they can occur at any age and anywhere in the central nervous system [2][3][4]. They are mainly characterized by a space-occupying lesion in the temporal and frontal lobes and are usually associated with chronic drug-resistant epilepsy [3][4][5]. The standard treatment is complete surgical resection [4,6], but even then ganglioglioma can develop a malignant transformation into anaplastic ganglioglioma (AGGL) classified as a grade III tumor [1,7].…”

“…They are mainly characterized by a space-occupying lesion in the temporal and frontal lobes and are usually associated with chronic drug-resistant epilepsy [3][4][5]. The standard treatment is complete surgical resection [4,6], but even then ganglioglioma can develop a malignant transformation into anaplastic ganglioglioma (AGGL) classified as a grade III tumor [1,7]. AGGL is a rare tumor only occasionally occurring de novo.…”