Low‐grade inflammation is associated with lower haemoglobin levels in healthy individuals: results from the Danish blood donor study

Kotzé, Sebastian; Pedersen, Ole Birger; Petersen, Mikkel Steen; Sørensen, Erik; Thørner, Lise Wegner; Sørensen, Cecilie J.; Rigas, Andreas S.; Hjalgrim, Henrik; Rostgaard, Klaus; Ullum, Henrik; Erikstrup, Christian

doi:10.1111/vox.12396

Cited by 13 publications

(16 citation statements)

References 26 publications

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“…Since low-grade inflammation is reported to be associated with anemia,15 low hemoglobin levels16 and atherosclerosis,14 aggressive endothelial repair that causes atherosclerosis could be associated with lower hemoglobin production, as indicated by low-grade inflammation.…”

Section: Discussionmentioning

confidence: 99%

“…Aging has been reported to be associated with low-grade inflammation,13 which can result in age-related diseases such as atherosclerosis 14. Since low-grade inflammation has been reported to be associated with anemia15 and low hemoglobin,16 aggressive endothelial repair that results in atherosclerosis could be associated with lower hemoglobin production.…”

Section: Introductionmentioning

confidence: 99%

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<p>Reticulocyte levels have an ambivalent association with hypertension and atherosclerosis in the elderly: a cross-sectional study</p>

Shimizu

Kawashiri

Yamanashi

et al. 2019

CIA

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Purpose: Age-related reduction in bone marrow activity has been shown to cause anemia, and hypertension and endothelial dysfunction (atherosclerosis) are age-related diseases. However, recent studies have revealed a close association between bone marrow activity and endothelial maintenance. This study aimed to determine the association between elevated reticulocyte levels in conjunction with vigorous bone marrow activity and hypertension and atherosclerosis among the elderly. Study population and Methods: To determine the associations between reticulocyte levels and hypertension and atherosclerosis, we conducted a cross-sectional study of 2,098 elderly Japanese individuals, aged between 60 and 89 years, who had participated in an annual health check-up in 2014. Results: Of the total study population, 1,348 individuals were diagnosed with hypertension (systolic blood pressure ≥140 mmHg and/or diastolic blood pressure ≥90 mmHg and/or having used antihypertensive medication), and 393 were diagnosed with atherosclerosis (carotid intima-media thickness ≥1.1 mm). Reticulocyte levels were found to be significantly positively associated with hypertension and inversely associated with atherosclerosis. Cardiovascular risk factor-adjusted odds ratios and 95% confidence intervals for hypertension and atherosclerosis, when raised incrementally by 1 standard deviation to determine reticulocyte levels (5.5×10 4 cells/μL for men and 5.0×10 4 cells/μL for women), were 1.12 (1.01, 1.25) and 0.83 (0.72, 0.94), respectively. Conclusion: Along with established cardiovascular risk factors, reticulocyte levels in elderly Japanese individuals were found to be positively associated with hypertension and inversely associated with atherosclerosis. This finding may help clarify the background mechanisms concerning the association between bone marrow activity and vascular remodeling.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

<p>Reticulocyte levels have an ambivalent association with hypertension and atherosclerosis in the elderly: a cross-sectional study</p>

Shimizu

Kawashiri

Yamanashi

et al. 2019

CIA

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“…The inflammatory response can induce anemia via the downregulation of iron absorption and erythropoiesis (47); independent associations between inflammation and low hemoglobin concentrations have been reported in Denmark (48), Sierra Leone (38), and the United States (49). Despite our separation of countries into groups on the basis of infection burden, we showed a similar inflammation prevalence (22–26%) in the infection groups.…”

Section: Discussionmentioning

confidence: 99%

Predictors of anemia in women of reproductive age: Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project

Wirth¹,

Woodruff²,

Engle‐Stone

et al. 2017

The American Journal of Clinical Nutrition

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“…We followed common practice by defining LGI as a CRP level above 3 mg/L and below or equal to 10 mg/L [ 19 , 32 , 33 ].…”

Section: Methodsmentioning

confidence: 99%

Low-Grade Inflammation Is Associated with Susceptibility to Infection in Healthy Men: Results from the Danish Blood Donor Study (DBDS)

et al. 2016

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IntroductionThe aim of this study was to examine whether low-grade inflammation (LGI) is associated with a subsequently increased risk of infection.MethodsWe included 15,754 healthy participants from the Danish Blood Donor Study, who completed a questionnaire on health-related items. LGI was defined as a C-reactive protein level between 3 and 10 mg/L. Infections were identified by ICD-10 codes in the Danish National Patient Register and ATC-codes in the Danish Prescription Register. Multivariable Cox proportional hazard analysis was used as the statistical model.ResultsDuring 53,302 person-years of observation, 571 participants were hospitalized for infection. Similarly, during 26,125 person-years of observation, 7,276 participants filled a prescription of antimicrobials. LGI was associated with increased risk of hospital-based treatment for infection only among men (hazard ratio = 1.60, 95% confidence interval (CI): 1.10–2.34) and specifically infections were abscesses and infections of the skin and subcutaneous tissue. Similarly, LGI was associated with the overall use of antimicrobials among men, and particularly with phenoxymethylpenicillin and broad-spectrum antimicrobials for treatment of urinary tract infections. The difference between men and women was not statistically significant.ConclusionsIn a large cohort of healthy individuals, LGI was associated with an increased risk of infection among healthy male blood donors.

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Low‐grade inflammation is associated with lower haemoglobin levels in healthy individuals: results from the Danish blood donor study

Cited by 13 publications

References 26 publications

<p>Reticulocyte levels have an ambivalent association with hypertension and atherosclerosis in the elderly: a cross-sectional study</p>

<p>Reticulocyte levels have an ambivalent association with hypertension and atherosclerosis in the elderly: a cross-sectional study</p>

Predictors of anemia in women of reproductive age: Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project

Low-Grade Inflammation Is Associated with Susceptibility to Infection in Healthy Men: Results from the Danish Blood Donor Study (DBDS)

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