&lt;p&gt;Reticulocyte levels have an ambivalent association with hypertension and atherosclerosis in the elderly: a cross-sectional study&lt;/p&gt;

Shimizu, Yūji; Kawashiri, Shin‐ya; Yamanashi, Hirotomo; Koyamatsu, Jun; Fukui, Shoichi; Kondo, Hideaki; Tamai, Mami; Nakamichi, Seiko; Maeda, Takahiro

doi:10.2147/cia.s197982

Cited by 21 publications

(18 citation statements)

References 37 publications

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“…In a previous study, were found that the MAF of rs3782886 (BRAP) was significantly positively associated with a high platelet count, which is associated with hypertension 16 , supports this mechanism. In addition, as in our previous study 15 , here, we found a significantly positive association between reticulocyte levels and hypertension (Table 2, Fig. 1b), while no significant association was found between reticulocyte levels and genetic factors (rs3782886 and rs671) (Tables 3, 4, Fig.…”

Section: Discussionsupporting

confidence: 90%

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Potential mechanisms underlying the association between single nucleotide polymorphism (BRAP and ALDH2) and hypertension among elderly Japanese population

Shimizu

Arima

Noguchi

et al. 2020

Sci Rep

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Minor allele frequency (MAF) of rs3782886 (BRAP) and rs671 (ALDH2) are reported to be inversely associated with blood pressure. Another study revealed that hematopoietic activity which is evaluated by reticulocytes could influenced on hypertension status partly by indicating activity of endothelial maintenance. Therefore, to evaluate the association between genetic factor and hypertension, influence of hematopoietic activity should be considered. A multi-faced analysis was performed in a simple general elderly population model (1,313 older Japanese aged 60-98 years). Participants were stratified by median values of reticulocytes (5.21 × 10 4 cells/μL for men and 4.65 × 10 4 cells/ μL for women). Independent of known cardiovascular risk factors, MAF of rs3782886 and rs671 are significantly inversely associated with hypertension for participants with high hematopoietic activity (high reticulocytes level) (fully adjusted odds ratio (ORs) were 0.72 (0.55, 0.96) for rs3782886 and 0.72 (0.54, 0.96) for rs671) but not for low reticulocytes count (the corresponding values were 1.05 (0.79, 1.39) and 1.08 (0.81, 1.45), respectively). Hematopoietic activity evaluated by reticulocytes levels could influence on the association between single nucleotide polymorphism (rs3782886 and rs671) and hypertension. Those results were efficient tool to clarify the part of the mechanism that underlying the association between genetic factor and hypertension. Atherosclerosis is generally considered to be positively associated with hypertension 1. A single nucleotide polymorphism (SNP) (rs3782886) in breast cancer suppressor BRCA1-related associated protein (BRAP) has been associated with the risk of developing myocardial infarction 2. Another study reported that BRAP activates inflammatory cascades, increasing the risk of carotid atherosclerosis 3. Even though the minor allele frequency (MAF) of rs3782886, and aldehyde dehydrogenase 2 (ALH2) polymorphism rs671 are significantly inversely associated with both systolic and diastolic blood pressure 4. Since strong linkage disequilibrium (LD) values between rs3782886 and rs671 have been reported 5 , rs671 could have same the characteristics of rs3782886. However, the mechanism underlying the association between hypertension and these genetic factors (rs3782886 and rs671) have not yet been elucidated. Atherosclerosis is involved in aggressive endothelial repair. Therefore, the favorable association of genetics factor (rs3782886 and rs671) with hypertension may be caused by stimulating endothelial repair.

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Section: Discussionsupporting

confidence: 90%

“…And reticulocyte is revealed to be significantly positively associated with hypertension ( Table 2, Fig. 1b) as like previous our study 15 . Since hypertension injures endothelium strongly, lower levels of reticulocytes among the elderly indicate a lower capacity for vascular maintenance.…”

Section: Discussionsupporting

confidence: 88%

Potential mechanisms underlying the association between single nucleotide polymorphism (BRAP and ALDH2) and hypertension among elderly Japanese population

Shimizu

Arima

Noguchi

et al. 2020

Sci Rep

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“…Factors such as alcohol consumption and smoking status influence vascular remodeling. Alcohol consumption influences γ-GTP and smoking status influences WBC [ 22 ]; therefore, we included γ-GTP and WBC as confounding factors rather than considering these factors directly, as in a previous study [ 6 , 13 , 23 ].…”

Section: Methodsmentioning

confidence: 99%

“…Hypertension is known to be strongly associated with atherosclerosis [ 5 , 6 ]. Previously, we reported that active endothelial repair, which results in atherosclerosis, might have a beneficial influence on maintaining muscle strength among hypertensive older Japanese [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Associations between handgrip strength and hypertension in relation to circulating CD34-positive cell levels among Japanese older men: a cross-sectional study

Shimizu

Kawashiri

Nobusue

et al. 2021

Environ Health Prev Med

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Background A positive association between handgrip strength and blood pressure has been reported. Since these factors are linked to the condition of the endothelium, the activity of endothelial repair might influence the association between handgrip strength and hypertension. Methods A cross-sectional study was conducted with 257 Japanese men aged 60–69 years who underwent an annual health checkup. As individuals with high level of circulating CD34-positive cells might show active endothelial repair, which plays an important role in vascular homeostasis, participants were stratified by circulating CD34-positive cell levels, using the median value of this population (0.96 cells/μL) as the cutoff. Results Independent of known cardiovascular risk factors, for participants with a high CD34-positive cell, handgrip strength is significantly positively associated with hypertension (odds ratio and 95% confidence interval of hypertension for 1 standard deviation increment of handgrip strength were 1.85 (1.19, 2.88) but not for participants with a low CD34-positive cell (0.91 (0.61, 1.37)). Conclusion The positive association between handgrip strength and hypertension is limited to high CD34-positive cells. This result may help clarify the role of vascular homeostasis in maintaining muscle strength.

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“…Long-term elevated blood pressure causes and promotes the formation and development of atherosclerosis. Immune and inflammation run through the whole process of the occurrence and development of atherosclerosis, of which, inflammation may be a bridge connecting hypertension and atherosclerosis, [ 17 , 18 ] and inflammation is an important participant on the mechanism of hypertension in atherosclerosis.…”

Section: Discussionmentioning

confidence: 99%

Correlation between single nucleotide polymorphisms in the 3 primer untranslated region of PTX3 and the risk of essential hypertension

Chen¹,

Liu²,

Pan³

et al. 2021

Medicine

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The aim of this study was to investigate the correlation between single-nucleotide polymorphisms (SNPs) in the 3 primer of untranslated region (3’UTR) of the Pentraxin 3 ( PTX3 ) gene and the risk of essential hypertension (EHT). PTX3 genotypes, rs2614, rs111451363, and rs73158510 locus, were found in 260 patients with EHT and 260 healthy controls. Quantitative real-time polymerase chain reaction was used to detect plasma hsa-miR-4766-5p levels. Enzyme-linked immunosorbent assay was used to detect plasma PTX3 levels. The dual-luciferase reporter assay was used to identify the binding site of hsa-miR-4766-5p to the PTX3 . PTX3 rs2614 locus T allele was a high risk factor for EHT (odds ratio [OR] = 2.76, 95% confidence interval [CI]: 1.86–4.09, P < .01). Sex and diabetes history affected the correlation between PTX3 gene rs2614 locus SNP and EHT risk. The CCG haplotype was a protective factor for EHT (OR = 0.40, 95% CI: 0.28–0.57, P < .01), whereas the TCG haplotype was a risk factor for EHT (OR = 2.35, 95% CI: 1.51–3.66, P < .01). The plasma PTX3 level of patients with EHT was significantly higher than that of the control group, and the difference was statistically significant ( P < .01). The area under the curve for EHT diagnosis in plasma PTX3 levels was 0.62 (95% CI: 0.57–0.66, P < .01). The plasma hsa-miR-4766-5p level in patients with EHT was significantly lower than that in the control group ( P < .01). The area under the curve for the diagnosis of EHT according to the plasma hsa-miR-4766-5p level was 0.88 (95% CI: 0.85–0.91, P < .01). Plasma PTX3 levels were significantly negatively correlated with hsa-miR-4766-5p levels in patients with EHT and the control group ( r = −0.87, −0.85, P < .01, P < .01). The PTX3 gene rs2614 locus C allele was the target gene of hsa-miR-4766-5p. The PTX3 rs2614 locus SNP is significantly associated with EHT risk.

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<p>Reticulocyte levels have an ambivalent association with hypertension and atherosclerosis in the elderly: a cross-sectional study</p>

Cited by 21 publications

References 37 publications

Potential mechanisms underlying the association between single nucleotide polymorphism (BRAP and ALDH2) and hypertension among elderly Japanese population

Potential mechanisms underlying the association between single nucleotide polymorphism (BRAP and ALDH2) and hypertension among elderly Japanese population

Associations between handgrip strength and hypertension in relation to circulating CD34-positive cell levels among Japanese older men: a cross-sectional study

Correlation between single nucleotide polymorphisms in the 3 primer untranslated region of PTX3 and the risk of essential hypertension

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