Low-grade myofibroblastic sarcoma: a case report of a child

Abstract

Introduction: Myofibroblastic sarcomas are malignant tumors characterized by the increased proliferation of myofibroblasts; they are rare and have been recently discovered. Observation: A 14-year-old adolescent had a large lesion in the inside of her right mandible. The diagnosis, after a difficult histological analysis, was low-grade myofibrosarcoma. The patient was treated with non-interruptive hemimandibulectomy. Discussion: Low-grade myofibroblastic sarcoma is one of four types of myofibroblastic sarcomas recognized by the WHO in the 2001 classification. This classification allows us to determine a prognosis based on histological characteristics of the lesion. Conclusion: In all cases of low-grade myofibroblastic sarcoma, the preferred treatment is curative surgical resection; but still poses a problem in the prosthetic rehabilitation of oral lesion.

Low-grade myofibroblastic sarcoma of the levator scapulae muscle: a case report and literature review

“…As presented in Table 2 , LGMS was located in the head and neck in 53 cases (51.5%); soft tissue 41 cases vs. bone 6 cases, trunk in 26 cases (25.2%); soft tissue 11 cases vs. bone 1 cases, and extremity in 24 cases (23.3%); soft tissue 12 cases vs. bone 7 cases. In the head and neck region, the most common site was the tongue [ 1 , 6 , 8 – 10 , 13 , 14 ], followed by the larynx [ 17 – 20 , 47 ], and gingiva [ 3 , 12 , 15 , 16 ]. LGMS was also observed in the mandible [ 10 , 23 ], face [ 23 ], skull [ 9 ], acoustic meatus [ 9 ], and deep tissue spaces, including the parapharyngeal space [ 28 ] as well as throughout the head and neck region.…”

“…LGMS is described as a distinct atypical myofibroblastic tumor, often with fibromatosis-like features and predilection for the head and neck [ 2 ]. Oral cavity [ 1 , 3 – 16 ] and larynx [ 17 – 20 ] cases are common, but a variety of tissues, including skin [ 21 – 23 ], breast [ 24 , 25 ], vulva [ 26 , 27 ], parapharyngeal space [ 28 ], jaw [ 1 , 10 ], nasal cavity [ 29 ], paranasal sinus [ 29 ], soft tissue of the cheek [ 7 , 23 ], and palate [ 3 , 30 ] have also been reported. LGMS has been characterized as having a low-grade malignant potential, the propensity to recur locally, and a low likelihood of distant metastases [ 1 , 6 , 31 ].…”