Background: Salivary gland tumors are a diverse group of uncommon neoplasms that are rare in pediatric patients. The aim of this study was to evaluate the clinicopathological profile and survival outcomes of pediatric patients affected by salivary gland tumors.Materials and methods: An extensive search was carried out using the MEDLINE/ PubMed, EMBASE, Scopus databases, and grey literature. The risk of bias was available in all papers included.Results: A total of 2,830 articles were initially retrieved with 54 remaining for data extraction, resulting in 2,937 cases. This comprised forty-five case series' and nine cohort studies. These tumors were slightly more prevalent in females (57.4%). The patients' age ranged from 0.3 to 19 years old, with a mean age of 13.3 years. Parotid was the most affected site (81.9%), and 99.2% of cases clinically exhibited a swelling.Presence of pain/tenderness was reported in 13.5% of the cases, with an average duration of 12.6 months for the appearance of symptoms. Most of the reported cases were malignant tumors (75.4%), with mucoepidermoid carcinoma the most common tumor of all tumors (44.8%), followed by pleomorphic adenoma (24.1%). Surgery alone was the leading treatment choice in 74.9% cases, and the 5-year overall survival rate of patients was 93.1%. Patients with symptoms (P = .001), local recurrence (P < .001), metastasis (P < .001), and those not undergoing surgery or surgery combined with radiotherapy (P < .001) showed lower survival rates. Conclusion:The pediatric patients present a high frequency of malignant salivary neoplasms and a high overall survival rate.

Background Analyze the clinical, demographic, histopathological, and immunohistochemical features of oral lymphoepithelial cyst (OLEC). Methods Samples were retrospectively retrieved from five oral pathology services. Clinical and demographic data were collected from patient charts. Histopathological and immunohistochemical (CD3 and CD20) features were evaluated. Data analysis involved descriptive statistics and bivariate analyses (P ≤ .05). Results Seventy‐seven cases were found among a total of 146 150 specimens (0.05%). OLEC was predominantly diagnosed in females (70.1%). Mean patient age was 46.51 years. The lesions arose mainly on the lateral border of the tongue (40.3%), measured up to 1 cm (61.0%), and were asymptomatic (64.9%). Twenty‐four lesions (31.2%) were white. Forty‐one cases (53.2%) presented lymphocytic inflammatory infiltrate with no specific arrangement. The cystic lining was composed of a non‐keratinized stratified epithelium (59.7%) presenting hyperplasia (39.0%). Connection with the surface, epithelium was found in 23 cases (29.9%) and 31 (40.3%) cases had two or more cystic cavities. The lumen content was predominantly desquamated cells (48.1%). Subgemmal neurogenous plaque was found in 11/42 (26.2%) cases involving the tongue. CD20+ cells predominated in 36/63 cases (57.2%), and lymphocytic inflammatory infiltrate was not always continuous around the cystic cavity (52.4%). Conclusion Lymphoepithelial cyst is an uncommon lesion of the oral cavity. The present study offers the largest sample of OLEC for which clinical, demographic, histopathological, and immunohistochemical features were evaluated. The clinical and demographic findings were similar to those described in previous reports, but the microscopic analyses revealed interesting aspects of the cystic epithelium and the lymphocytic inflammatory infiltrate in OLEC.

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Objetivo: Estabelecer o perfil epidemiológico das lesões odontogênicas provenientes do Departamento de Patologia e Medicina Legal (DPML) da Faculdade de Medicina (FM) da Universidade Federal do Amazonas (UFAM), analisando os tipos histológicos mais prevalentes de cistos e tumores Objetivo: estabelecer o perfil epidemiológico das lesões odontogênicas provenientes do Departamento de Patologia e Medicina Legal (DPML) da Faculdade de Medicina (FM) da Universidade Federal do Amazonas (UFAM), analisando os tipos histológicos mais prevalentes de cistos e tumores odontogênicos assim como suas características clinicopatológicas. Material e Métodos: cento e quarenta e oito casos de lesões odontogênicas, entre os anos de 1999 e 2014, foram recuperados do DPML/FM/UFAM e analisados quanto ao sexo, idade, raça, localização anatômica e tipo histológico. Esses dados foram submetidos à análise descritiva. Resultados: do total de 148 pacientes acometidos por lesões odontogênicas, encontrou-se leve predileção pelo sexo masculino (54%, n = 80), na segunda década de vida (34,1%, n = 47) e sendo a mandíbula o sítio anatômico mais acometido com 59,7% (n = 77) dos casos. Quanto aos tipos histológicos das lesões, 68,9% (n = 102) foram de cistos e 31,1% (n = 46) de tumores odontogênicos. Dos cistos, o tipo histológico mais prevalente foi o periapical (39,3%, n = 40) e dentre os tumores, o tipo mais comum foi o ameloblastoma (45,6%, n = 21). Conclusão: as lesões odontogênicas prevaleceram em homens, na segunda década de vida e região posterior de mandíbula. Os cistos foram mais prevalentes em relação aos tumores odontogênicos e o padrão de distribuição histológica de ambas as categorias foi similar ao encontrado na literatura, em que o cisto periapical e o ameloblastoma são as lesões predominantes.

Background To evaluate the frequency and analyze demographic and clinical characteristics of individuals with a histopathological diagnosis of oral lymphatic malformations (OLMs). Methods A multicenter study was performed, collecting biopsy record data from a consortium of Brazilian Oral and Maxillofacial Pathology Centers. A review was also conducted to compare this data with cases already available in the literature. Results This study retrieved 208 cases of OLM in the multicenter study and 1035 cases in the literature review. In both, OLMs affected male and female individuals equally, with the most affected site being the tongue. Individuals ≥60 years of age were uncommonly affected. Symptomatic and larger lesions were more commonly reported in the literature review. Conclusions This study comprises the largest sample of OLMs to date. OLMs are rare conditions, without sex predilection. The elderly proved to be less frequently affected, and the tongue is the most commonly affected site.