State-of-the-science concepts of HPV-related oropharyngeal squamous cell carcinoma: a comprehensive review

Louredo, Brendo Vinícius Rodrigues; Prado‐Ribeiro, Ana Carolina; Brandão, Thaís Bianca; Epstein, Joel B.; Migliorati, Cesar A.; Piña, Alicia Rumayor; Kowalski, Luiz Paulo; Vargas, Pablo Agustín; Lopes, Márcio Ajudarte; Santos‐Silva, Alan Roger

doi:10.1016/j.oooo.2022.03.016

Cited by 11 publications

(11 citation statements)

References 107 publications

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“…Results regarding both their number of functional type content of specific granules and mainly the clinical significance are still a matter of debate and results are controversial. The increase in the number of MCs in malignant tumors has been reported by many authors [ 15 ]. Located close to the tumor or even in the tumor area, usually, MCs do not show degranulation and they are found in the proximity of tumor cells.…”

Section: Introductionmentioning

confidence: 76%

The mast cell reaction in premalignant and malignant lesions of the head and neck

Cosoroabă

Gaje²,

Ceauşu³

et al. 2022

Rom J Morphol Embryol

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Head and neck squamous cell carcinoma (HNSCC) is one of the most frequent and aggressive neoplasms of this anatomical region. Many studies evaluated the neoplastic cells, but few works focused on the tumor microenvironment. In the present study, we investigated the distribution and mast cell density (MCD) in malignant and premalignant lesions of the oral cavity, tongue, pharynx, and larynx. There were analyzed 52 specimens of HNSCC, and 15 biopsies taken from patients with dysplasia. Results were compared with those found in a control group of 10 biopsies of oral mucosa from patients with inflammatory diseases. Slides stained with Hematoxylin-Eosin were used for the histopathological diagnosis and grade, and mast cells (MCs) were identified by immunohistochemistry, using anti-MC tryptase. MCs were counted using a method similar to that proposed for microvessel density. We found a significant increase in the number of MCs from the normal oral mucosa until overt carcinoma. Unlike normal tissues, in HNSCC, many MCs were found between tumor cells. We found no relationship between MCs and blood vessels in the tumor area. A significant statistical correlation was found between dysplastic and malignant tumors, but not between tumors with a different grade. Also, it was not found relationship between MCD and the anatomical location of the tumor. Based on these results, we believe that MCD evaluated by anti-MC tryptase is an independent factor of prognosis and reflects an unfavorable outcome.

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Section: Introductionmentioning

confidence: 76%

The mast cell reaction in premalignant and malignant lesions of the head and neck

Cosoroabă

Gaje²,

Ceauşu³

et al. 2022

Rom J Morphol Embryol

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“…Approximately 80% of oropharyngeal cancers in the US are associated with HPV. 5 These specific tumor types have been the main reason for increasing incidences, especially in the younger population.…”

Section: Risk Factorsmentioning

confidence: 99%

“…In 2019, Oregon passed legislation to allow dental healthcare providers to prescribe and administer any vaccine as part of Public Health Modernization Implementation. 5 In 2018, Oregon’s HPV initiation dose was 67% and HPV completion doses were 46%, which has increased by 6% and 7%, respectively, in 2022. In 2019, 71.5% of adolescents aged 13-17 years had received one dose of HPV, and 54.2% had completed the HPV vaccination.…”

Section: Vaccinationmentioning

confidence: 99%

Human Papilloma Virus (HPV) and the Current State of Oropharyngeal Cancer Prevention and Treatment

Gribb¹,

Wheelock²,

Park³

2023

Delaware Journal of Public Health

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“…Some authors consider that various viruses have been associated with oral cancerogenesis [ 26 , 27 , 28 , 29 , 30 , 31 ]. Among them, HPV is historically and universally responsible for head and neck cancers of the oropharynx (OPC) and, as a matter of fact, from a clinical standpoint the evaluation of HPV-related markers is a valid parameter in the potential adjuvant or neoadjuvant treatment of oropharyngeal cancer regarding radiotherapy.…”

Section: Introductionmentioning

confidence: 99%

“…Hence, HPV’s pathogenic role in OSCC is still debated. However, the literature reports a better prognosis in HPV-positive OSCC than HPV-unrelated OSCC, despite the finding that HPV in the oral mucosae is rarer than in the pharynx [ 26 , 33 , 35 , 36 ].…”

Section: Introductionmentioning

confidence: 99%

Personalized Medicine in Oral Oncology: Imaging Methods and Biological Markers to Support Diagnosis of Oral Squamous Cell Carcinoma (OSCC): A Narrative Literature Review

Menditti,

Santagata,

Imola

et al. 2023

JPM

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For decades, oral squamous cell carcinoma (OSCC) has been one of the most prevalent and mortal cancers worldwide. The gold standard for OSCC diagnosis is still histopathology but this narrative multidisciplinary review has the aim to explore the literature about conventional OSCC prognostic indicators related to the pTNM stage at the diagnosis such as the depth of invasion and the lymphovascular invasion associated with distant metastasis as indicators of poor life expectancy. Despite its multifactorial nature and recognizable precursors, its diagnosis at the early stages is still challenging. We wanted to highlight the importance of the screening as a primary weapon that a stomatologist should consider, intercepting all at-risk conditions and lesions associated with OSCC and its early stages. This narrative review also overviews the most promising imaging techniques, such as CT, MRI, and US-echography, and their application related to clinical and surgical practice, but also the most-investigated prognostic and diagnostic tissue and salivary biomarkers helpful in OSCC diagnosis and prognostic assessment. Our work highlighted remarkable potential biomarkers that could have a leading role in the future. However, we are still far from defining an appropriate and concrete protocol to apply in clinical practice. The hope is that the present and future research will overcome these limitations to benefit patients, clinicians, and welfare.

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State-of-the-science concepts of HPV-related oropharyngeal squamous cell carcinoma: a comprehensive review

Cited by 11 publications

References 107 publications

The mast cell reaction in premalignant and malignant lesions of the head and neck

The mast cell reaction in premalignant and malignant lesions of the head and neck

Human Papilloma Virus (HPV) and the Current State of Oropharyngeal Cancer Prevention and Treatment

Personalized Medicine in Oral Oncology: Imaging Methods and Biological Markers to Support Diagnosis of Oral Squamous Cell Carcinoma (OSCC): A Narrative Literature Review

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