Low-grade papillary adenocarcinoma of palatal salivary gland origin

Schneiderian Papillomas and Nonsalivary Glandular Neoplasms of the Head and Neck

“…LGPASO occurs almost exclusively in the oral cavity, especially the palate (148,149). Furthermore, it arises submucosally from minor salivary glands rather than from the surface, as does the PACN.…”

Salivary Gland Neoplasia: A Review for the Practicing Pathologist

“…The proliferations are often centered on a nidus, commonly a focus of perineural invasion, lending a targetoid appearance. PLGA are only focally papillary, so an extensive papillary component should raise the possibility of the more aggressive low-grade palatal papillary adenocarcinoma (74,75) or papillary cystadenocarcinoma with its well developed papillae and fibrous cores. Also potentially complicating interpretation is that the stroma may be fibrous, mucoid or hyaline in appearance, not unlike that of adenoid cystic carcinoma.…”

Polymorphous low grade adenocarcinoma

“…A true papillary cystadenocarcinoma portends a more aggressive clinical course with lymph node metastases and a higher frequency of local recurrence. 3,5,17,21,26,28,31,32 This biologic behavior is distinctly contrary to that of PLGA.…”