Low high-density lipoprotein cholesterol and high triglycerides lipid profile in neuromyelitis optica spectrum disorder: Associations with disease activity and disability

Cho, Eun Bin; Cho, Hye‐Jin; Choi, Misong; Seok, Jin Myoung; Shin, Hee Young; Kim, Byoung Joon; Min, Ju-Hong

doi:10.1016/j.msard.2020.101981

Cited by 11 publications

(8 citation statements)

References 31 publications

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“…Similar to that of the MS group, there was no subgroup that changed the PD risk in stratified analyses of NMOSD, although there was a tendency for HRs to be larger in patients with NMOSD with dyslipidaemia. NMOSD might cause dyslipidaemia, and dyslipidaemia might increase disease activity or disability by enhancing the inflammatory response 39. Dyslipidaemia is associated with inflammation as well as oxidative stress and the dysfunction of mitochondria 40.…”

Section: Discussionmentioning

confidence: 99%

Risk of Parkinson’s disease in multiple sclerosis and neuromyelitis optica spectrum disorder: a nationwide cohort study in South Korea

Kwon

Jung

Han

et al. 2022

J Neurol Neurosurg Psychiatry

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BackgroundNeurodegeneration is associated with pathogenesis of both multiple sclerosis (MS) and neuromyelitis optica (NMOSD). Parkinson’s disease (PD) is a representative neurodegenerative disease, however, whether MS or NMOSD is associated with risk of PD is not known.MethodsMS and NMOSD cohorts were collected from the Korean National Health Insurance Service between 1 January 2010 and 31 December 2017, using International Classification of Diseases 10th revision diagnosis codes and information in the Rare Intractable Disease management programme. The PD incidence rate that occurred after a 1-year lag period was calculated and compared with that of a control cohort matched for age, sex, hypertension, diabetes and dyslipidaemia in a 1:5 ratio.ResultsThe incidence rates of PD in patients with MS and NMOSD were 3.38 and 1.27 per 1000 person-years, respectively, and were higher than that of their matched control groups. The adjusted HR of PD was 7.73 (95% CI, 3.87 to 15.47) in patients with MS and 2.61 (95% CI, 1.13 to 6.02) in patients with NMOSD compared with matched controls. In both patients with MS and NMOSD, there were no significant differences in relative risk when stratified by sex, age, diabetes, hypertension and dyslipidaemia.ConclusionThe PD risk was higher in patients with MS and NMOSD compared with healthy controls and was particularly high in patients with MS. Further investigations should be performed to determine the pathophysiology and occurrence of PD in patients with MS and NMOSD.

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Section: Discussionmentioning

confidence: 99%

Risk of Parkinson’s disease in multiple sclerosis and neuromyelitis optica spectrum disorder: a nationwide cohort study in South Korea

Kwon

Jung

Han

et al. 2022

J Neurol Neurosurg Psychiatry

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“…HDL is considered an anti-inflammatory factor that can prevent the production of pro-inflammatory cytokines and affect a series of immune cell reactions, including those involving macrophages and B and T lymphocytes ( 21 ). HDL is closely related to monocytes and can regulate the activation, adhesion, and migration of monocytes ( 46 , 47 ).…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have shown that the serum apolipoprotein A-1 levels in patients with NMOSD are significantly lower than those in healthy controls ( 22 ), and HDL levels are significantly lower during active disease than during remission. Further, dyslipidemia with low HDL is related to disease activity and disability in patients with AQP4 positive NMOSD ( 21 ). Similar results were observed in the present study.…”

Section: Discussionmentioning

confidence: 99%

“…High-density lipoprotein (HDL) is considered an anti-inflammatory factor that has immunomodulatory and antioxidant effects on endothelial cells ( 18 – 20 ) and can prevent the production of pro-inflammatory cytokines. Studies have shown that low HDL is related to disease activity and disability in patients with AQP4-positive NMOSD, which may be associated with the decrease in the levels of apolipoprotein (apo) A-I, the main component of HDL in serum ( 21 , 22 ).…”

Section: Introductionmentioning

confidence: 99%

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Monocyte to High-Density Lipoprotein Ratio: A Novel Predictive Marker of Disease Severity and Prognosis in Patients With Neuromyelitis Optica Spectrum Disorders

Zhang

Zhou

et al. 2021

Front. Neurol.

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Background and Purpose: To investigate the association of monocyte to high-density lipoprotein ratio (MHR) with disease severity and prognosis in patients with neuromyelitis optica spectrum disorders (NMOSD).Methods: This retrospective study included 125 patients with NMOSD. Demographic and clinical parameters, including the MHR, were assessed. The initial Expanded Disability Status Scale (EDSS) score and relapse rate were used to evaluate disease severity and prognosis, respectively. Correlations between MHR and disease severity and relapse rate were analyzed. The predictive value of MHR for prognosis was evaluated using receiver operating characteristic (ROC) curve analysis.Results: Compared with the low MHR group, the initial EDSS score (median 4.5 vs. 5.5%, P = 0.025) and relapse rate (51.61 vs. 30.16%, P = 0.015) were significantly higher in the high MHR group. MHR was positively correlated with the initial EDSS score (r = 0.306, P = 0.001). Multivariate analysis showed that MHR was significantly associated with severity (odds ratio = 7.90, 95% confidence interval [CI] = 1.08–57.82, P = 0.041), and it was a significant predictor of disease prognosis (hazard ratio = 3.12, 95% CI = 1.02–9.53, P = 0.046). The median relapse interval of the high MHR group was 24.40 months. When the MHR was higher than 0.565, the risk of relapse was high [sensitivity, 33.3%; specificity, 91.9%; area under the ROC curve, 0.642 (95% CI = 0.54–0.74, P = 0.007)].Conclusion: MHR is a novel predictive marker of disease severity and prognosis in patients with NMOSD. Early monitoring and reduction of MHR may allow earlier intervention and improved prognosis.

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“…Researchers indicate that higher serum high-density lipoprotein cholesterol (HDL-C) is associated with lower levels of blood–brain barrier (BBB) injury in multiple sclerosis (MS) ( 8 , 9 ). In neuromyelitis optic spectrum disorder (NMOSD), low HDL-C and high triglyceride (TG) levels were positively associated with poor recovery and relapse ( 10 , 11 ).…”

Section: Introductionmentioning

confidence: 99%

Plasma lipid profiles and homocysteine levels in anti-N-methyl-D-aspartate receptor encephalitis

Wang

Qiao²,

Wang³

et al. 2023

Front. Neurol.

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IntroductionWe aimed to investigate whether lipid profiles and homocysteine levels in patients with anti-N-methyl-D-aspartate receptor encephalitis are related to clinical presentation and prognosis, which may contribute to further research on the pathogenesis and treatment of this disease.MethodsThis study included a total of 43 patients with anti-N-methyl-D-aspartate receptor encephalitis and 43 sex–age-matched healthy controls. Baseline demography, clinical data, patient outcomes, and ancillary examination results were recorded. Patients were followed up every 2–3 months during the first year. The modified Rankin Scale score was used to evaluate the therapeutic effect and clinical outcome.ResultsAmong the 43 patients included in this study, 55.81% were male, the mean age of onset was 27 years old, and the median modified Rankin Scale score on admission was 3.0. Apolipoprotein A-1 was significantly lower in patients with anti-N-methyl-D-aspartate receptor encephalitis compared with healthy controls (p = 0.004). Compared with healthy controls, homocysteine (p = 0.002), apolipoprotein B (p = 0.004), Lpa (p = 0.045), and apolipoprotein B/apolipoprotein A-1 (p = 0.001) were significantly increased in patients with anti-N-methyl-D-aspartate receptor encephalitis. According to the modified Rankin Scale scores, 6 months after discharge, 72.09% of patients had a good prognosis and 27.91% had a poor prognosis. In the good prognosis group, age (p = 0.031), lipoprotein a (p = 0.023), apolipoprotein A-1 (p = 0.027) at baseline, and the modified Rankin Scale score on admission (p = 0.019) were significantly higher than those in the poor prognosis group.ConclusionThis study suggests the possibility that serum lipid profile and homocysteine play an important role in the pathogenesis of anti-N-methyl-D-aspartate receptor encephalitis, providing support for lipid-lowering treatment of anti-N-methyl-D-aspartate receptor encephalitis patients.

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Low high-density lipoprotein cholesterol and high triglycerides lipid profile in neuromyelitis optica spectrum disorder: Associations with disease activity and disability

Cited by 11 publications

References 31 publications

Risk of Parkinson’s disease in multiple sclerosis and neuromyelitis optica spectrum disorder: a nationwide cohort study in South Korea

Risk of Parkinson’s disease in multiple sclerosis and neuromyelitis optica spectrum disorder: a nationwide cohort study in South Korea

Monocyte to High-Density Lipoprotein Ratio: A Novel Predictive Marker of Disease Severity and Prognosis in Patients With Neuromyelitis Optica Spectrum Disorders

Plasma lipid profiles and homocysteine levels in anti-N-methyl-D-aspartate receptor encephalitis

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