2014
DOI: 10.1620/tjem.234.99
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Low-Intensity Aerobic Exercise Mitigates Exercise-Induced Bronchoconstriction by Improving the Function of Adrenal Medullary Chromaffin Cells in Asthmatic Rats

Abstract: Exercise is one of the most common triggers of bronchoconstriction in patients with asthma. The low levels of circulating epinephrine produced by the adrenal medullary chromaffin cells (AMCCs) are associated with exercise-induced bronchoconstriction (EIB) in asthmatics. In the present study, we tested the hypothesis that low-intensity aerobic exercise may ameliorate EIB using a rat model of asthma. Male Sprague-Dawley rats at 7 weeks of age, sensitized with ovalbumin or treated with saline, were subjected to l… Show more

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Cited by 7 publications
(3 citation statements)
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“…However, long-term high expression of TGF-β1 can lead to excessive tissue repair and further generate fibrosis [39]. Cellular TGF-β1 is regulated by adrenal hormones, and lower intensity aerobic exercise may significantly reduce the level of adrenaline in the circulation of patients with hypertension and diabetes [40,41]. Therefore, exercise in the present study may decrease the expression of TGF-β1 in the myocardium of diabetic rats and reduce the degree of myocardial fibrosis by inhibiting the secretion of adrenaline in diabetic rats [42].…”
Section: Discussionmentioning
confidence: 99%
“…However, long-term high expression of TGF-β1 can lead to excessive tissue repair and further generate fibrosis [39]. Cellular TGF-β1 is regulated by adrenal hormones, and lower intensity aerobic exercise may significantly reduce the level of adrenaline in the circulation of patients with hypertension and diabetes [40,41]. Therefore, exercise in the present study may decrease the expression of TGF-β1 in the myocardium of diabetic rats and reduce the degree of myocardial fibrosis by inhibiting the secretion of adrenaline in diabetic rats [42].…”
Section: Discussionmentioning
confidence: 99%
“…In addition, there is evidence demonstrating that asthmatic patients have increased vagal tone (Lewis et al., ); however, the effect of AT on this autonomic imbalance remains unknown. Lastly, endogenous cortisol is a natural, powerful anti‐inflammatory hormone (Barnes, 1998), and recent evidence suggests that AT increases the corticosteroid plasma levels in a rat asthma model (Qin et al., ). Based on these previous studies and our findings, we speculate that AT increases plasma cortisol levels and the GR expression that could potentiate the anti‐inflammatory effects induced by AT during asthma pathophysiology.…”
Section: Discussionmentioning
confidence: 99%
“…Furthermore, low-intensity aerobic exercise has been associated with an increase in the levels of serum epinephrine mitigating EIB in asthmatic Sprague-Dawley rats (44). In these studies, the exercise attenuated the airway resistance in asthmatic rats, but not in normal rats, however, the species used in our study differs from theirs.…”
Section: Discussionmentioning
confidence: 99%