Low-intensity extracorporeal shock wave therapy for erectile dysfunction: Myths and realities

Bocchino, Alessia Celeste; Pezzoli, Marta; Martínez-Salamanca, Juan Ignacio; Russo, Giorgio Ivan; Giudice, Arturo Lo; Cocci, Andrea

doi:10.4111/icu.20220327

Cited by 9 publications

(4 citation statements)

References 67 publications

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“…у пациентов с лёгкой васкулогенной эректильной дисфункцией, слабо реагирующей на ингибиторы фдэ-5, может использоваться низкоинтенсивная экстракорпоральная ударноволновая терапия [67]. терапия стволовыми клетками, инъекции обогащённой тромбоцитами плазмы и генная терапия ещё не имеют достаточной доказательной базы для обоснованного применения в практике лечения эректильной дисфункции [68,69].…”

Section: результатыunclassified

Sexual dysfunction in men and women with arterial hypertension

Kanorskii

2024

jour

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Sexual dysfunction is often associated with hypertension but is not recognized, reported, or adequately treated. Research on sexual dysfunction is sparse, which may be due to the taboo nature of the topic. A literature search was conducted in five databases (PubMed, Web of Science, Scopus, Cochrane Library and PsycINFO) to identify articles published over the past ten years (from 2014 to 2024), using the keywords “sexual dysfunction”, “arterial” hypertension", "antihypertensive drugs", "erectile dysfunction". The review examines the prevalence, pathophysiology, clinical manifestations of sexual dysfunction in men and women, its relationship with arterial hypertension, antihypertensive therapy, concomitant pathology, and possible methods of correction.

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Section: результатыunclassified

Sexual dysfunction in men and women with arterial hypertension

Kanorskii

2024

jour

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“…Thus, patients can save a lot of time or money [ 65 ]. Because of these beneficial properties, Li-ESWT has become a treatment of choice for many conditions, including musculoskeletal disorders [ 66 67 ], wound healing [ 68 ], urological disorders [ 69 ], and restoration of erectile function [ 70 71 72 ]. This article summarizes some of the preclinical research results of Li-ESWT for ED, as shown in Table 3 [ 73 74 75 76 77 78 79 80 81 ].…”

Section: Preclinical Research Of Ed Biotherapymentioning

confidence: 99%

Regenerative therapies as a potential treatment of erectile dysfunction

2023

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Erectile dysfunction (ED) is the most common sexual dysfunction disease in adult males. ED can be caused by many factors, such as vascular disease, neuropathy, metabolic disturbances, psychosocial causes, and side effects of medications. Although current oral phosphodiesterase type 5 inhibitors can achieve a certain effect, they cause temporary dilatation of blood vessels with no curative treatment effects. Emerging targeted technologies, such as stem cell therapy, protein therapy, and low-intensity extracorporeal shock wave therapy (Li-ESWT), are being used to achieve more natural and long-lasting effects in treating ED. However, the development and application of these therapeutic methods are still in their infancy, and their pharmacological pathways and specific mechanisms have not been fully discovered. This article reviews the preclinical basic research progress of stem cells, proteins, and Li-ESWT therapy, as well as the current status of clinical application of Li-ESWT therapy.

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“…Bochchino et al [55] conducted a meta-analysis of data from the PubMed database, identifying 139 articles referring to the application of Li-ESWT in ED. Out of this number, 52 publications were included in the final analysis: 17 studies on vasculogenic ED, 4 papers carried out on patients with ED and diabetes, 5 studies focusing on ED in patients after pelvic floor surgery, and 26 papers on ED of undetermined cause.…”

Section: Meta-analyses Regarding Li-eswt In Edmentioning

confidence: 99%

Low-intensity extracorporeal shock wave therapy in the treatment of erectile dysfunction. Diagnostic and therapeutic options — a literature review

Rujna,

Chochowska,

Cieślikowski

et al. 2023

Journal of Sexual and Mental Health

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Low-intensity extracorporeal shock wave therapy (Li-ESWT) is a modern therapeutic option for erectile dysfunction (ED). The European Association of Urology (EAU) has classified it as a first-line treatment for ED. The use of Li-ESWT is recommended in appropriately informed patients with mild erectile dysfunction (EF). The recommendations include the use of LI-ESWT for patients who respond poorly to drug therapy and those who, for individual reasons, are unable or unwilling to use vasoactive substances. It is worth noting that the level of recommendation is described as weak (insufficient evidence of efficacy, indicating the need for further research). The mechanism of action of Li-ESWT is not well understood, but it is known that it affects the formation of new blood vessels, promotes quantitative and qualitative improvement of vascular endothelial cells, and increases the production of nitric oxide (has a nutritional effect, generating congestion). Improvement of erectile function in people undergoing Li-ESWT was noted in patients with vascular ED, and importantly, studies are underway to apply this form of therapy to other etiopathogenesis of ED. Li-ESWT results in an improvement in EF as measured by the International Index of ErectileFunction (IIEF), an increase in the average Erectile Hardness Score (EHS), and an improvement in quality of sexual life; however, the level of increase remains clinically unsatisfactory. The efficacy of Li-ESWT has been confirmed in studies in patients with the most advanced vascular ED. Importantly, there were no side effects both during and after therapy and the improvement in EF was sustained long-term (up to 2 years). The advantages of Li-ESWT therapy are associated with the removal of the cause of vasogenic ED, which transfers into improved sexual performance, allows patients to regain spontaneity of intercourse and prompts wider use of this innovative therapy.

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Low-intensity extracorporeal shock wave therapy for erectile dysfunction: Myths and realities

Cited by 9 publications

References 67 publications

Sexual dysfunction in men and women with arterial hypertension

Sexual dysfunction in men and women with arterial hypertension

Regenerative therapies as a potential treatment of erectile dysfunction

Low-intensity extracorporeal shock wave therapy in the treatment of erectile dysfunction. Diagnostic and therapeutic options — a literature review

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