Low-intensity pulsed ultrasound prevents muscle atrophy induced by type 1 diabetes in rats

Tang, Liang; Li, Nan; Jian, Wenqi; Kang, Yiting; Yin, Bin; Sun, Shuxin; Guo, Jianzhong; Sun, Lijun; Ta, Dean

doi:10.1186/s13395-017-0145-7

Cited by 38 publications

(27 citation statements)

References 44 publications

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“…Skeletal muscle is one of the largest organs in the human body and is, quantitatively, the most important tissue involved in maintaining glucose homeostasis under insulin-stimulated conditions. Type 1 diabetic subjects without insulin treatment display a dramatic loss of muscle, which leads to higher blood glucose concentration, resulting in a vicious cycle 3 .…”

Section: Introductionmentioning

confidence: 99%

Influence of melatonin on the activity of main enzymes of cori cycle in skeletal muscles, heart, liver and kidneys of alloxan-induced diabetic rats

Kushnir¹,

Yaremii²,

Kyshkan³

et al. 2019

Arch Balk Med Union

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L'influence de la mélatonine sur l'activité des enzymes principales du cycle de Cori dans les muscles du squelette, le coeur, le foie et les reins de rats avec diabète induit par l'alloxane Introduction. La mélatonine, un puissant agent antioxydant, est essentielle à l'homéostasie et à la régulation du glucose. L'objectif de l'étude a été de déterminer l'influence de la mélatonine sur les taux basaux de glucose dans le sang, les activités de la glucose-6-phosphatase dans les reins et le foie, la pyruvate-kinase dans les muscles et le coeur, la teneur en glycogène dans les muscles et le coeur de rats diabétiques à l'alloxane. Matériaux et méthodes. Le diabète a été provoqué chez des rats Wistar mâles par voie intrapéritonéale avec une injection unique d'alloxane (170 mg / kg). Quatre jours après l'induction du diabète, les rats ont été divisés en groupes diabétique et diabétique à la mélatonine (10 mg / kg «Sigma» USA, quotidiennement

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Section: Introductionmentioning

confidence: 99%

Influence of melatonin on the activity of main enzymes of cori cycle in skeletal muscles, heart, liver and kidneys of alloxan-induced diabetic rats

Kushnir¹,

Yaremii²,

Kyshkan³

et al. 2019

Arch Balk Med Union

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“…The rs4081134 polymorphism was speculated to alter the centroid secondary structure and minimal free energy, which changed the folding of MEG3. The rs941576 located in MEG3 was proved to be significantly associated with type I diabetes, which contributed to skeletal muscle defects and serious atrophy ( Tang et al, 2017 ). In the present study, eight SNPs of MEG3 were detected in different meat-type pigs.…”

Section: Discussionmentioning

confidence: 99%

Effects and Molecular Mechanism of Single-Nucleotide Polymorphisms of MEG3 on Porcine Skeletal Muscle Development

et al. 2021

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Maternally expressed gene 3 (MEG3) is a long non-coding RNA that is a crucial regulator of skeletal muscle development. Some single-nucleotide polymorphism (SNP) mutants in MEG3 had strong associations with meat quality traits. Nevertheless, the function and mechanism of MEG3 mutants on porcine skeletal muscle development have not yet been well-demonstrated. In this study, eight SNPs were identified in MEG3 of fat- and lean-type pig breeds. Four of these SNPs (g.3087C > T, g.3108C > T, g.3398C > T, and g.3971A > C) were significantly associated with meat quality and consisted of the CCCA haplotype for fat-type pigs and the TTCC haplotype for lean-type pigs. Quantitative real-time PCR results showed that the expression of MEG3-TTCC was higher than that of MEG3-CCCA in transcription level (P < 0.01). The stability assay showed that the lncRNA stability of MEG3-TTCC was lower than that of MEG3-CCCA (P < 0.05). Furthermore, the results of qRT-PCR, Western blot, and Cell Counting Kit-8 assays demonstrated that the overexpression of MEG3-TTCC more significantly inhibited the proliferation of porcine skeletal muscle satellite cells (SCs) than that of MEG3-CCCA (P < 0.05). Moreover, the overexpression of MEG3-TTCC more significantly promoted the differentiation of SCs than that of MEG3-CCCA (P < 0.05). The Western blot assay suggested that the overexpression of MEG3-TTCC and MEG3-CCCA inhibited the proliferation of SCs by inhibiting PI3K/AKT and MAPK/ERK1/2 signaling pathways. The overexpression of the two haplotypes also promoted the differentiation of SCs by activating the JAK2/STAT3 signaling pathway in different degrees. These data are valuable for further studies on understanding the crucial role of lncRNAs in skeletal muscle development.

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“…Given these data, the use of Mann-Whitney test was considered sufficient for valid conclusions. Differences were considered to be statistically significant at P≤0.05 [14,15].…”

Section: Methodsmentioning

confidence: 99%

“…Skeletal muscle is one of the largest organs in the human body and is, quantitatively, the most important tissue involved in maintaining glucose homeostasis under insulinstimulated conditions. Type 1 diabetic subjects without insulin treatment display a dramatic loss of muscle, which leads to a higher blood glucose concentration, resulting in a vicious cycle [3].…”

Section: Introductionmentioning

confidence: 99%

Influence of melatonin on glutathione system in rats skeletal muscle under alloxan induced diabetes

Kushnir¹,

Yaremii²,

Shvets³

et al. 2018

Fiziol Zh

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The aim was to determine the influence of melatonin on basal levels of glucose (BG), the levels of protein carbonyl content, HbA 1c and thiobarbituric acid reactive compounds (TBCRC), reduced glutathione (GSH), activities of glutathione reductase [EC 1.6.4.2] (GR), glutathione peroxidase [EC 1.11.1.9] (GPx), glucose-6-phosphate dehydrogenase [EC 1.1.1.49] (G-6-PhD) in the muscles of alloxan diabetic rats (DM1T). BG levels in blood of rats with DM1T increased on 139%, while in group of alloxan diabetic rats with impaired glucose tolerance (IGT)-were not differ from control. HbA 1c levels in the blood of animals with DM1T and IGT exceeded control by 219% and 123%, the level of protein carbonyl groups-by 76% and 36%, the level of TBCRC-by 58% and 36% respectively. Activities of GR, GPx, G-6-PhD and the level of GSH were decreased on 25%, 18%, 50% and 42% in rats with DM1T while in rats with IGT these indexes (besides GSH) were increased on 37%, 22%, 35% respectively than control. Melatonin lowered the BG level on 56% in DM1T rats in comparison to initial levels. It normalized activities of GR, GPx, G-6-PhD and lipid peroxidation, and protein carbonylation as well as hemoglobin glycosylation, so these indexes did not differ from control. Thus, melatonin has strong potential to regulate glucose homeostasis through enhanced glucose consumption, decreased oxidative stress by activation of the glutathione protection system.

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Low-intensity pulsed ultrasound prevents muscle atrophy induced by type 1 diabetes in rats

Cited by 38 publications

References 44 publications

Influence of melatonin on the activity of main enzymes of cori cycle in skeletal muscles, heart, liver and kidneys of alloxan-induced diabetic rats

Influence of melatonin on the activity of main enzymes of cori cycle in skeletal muscles, heart, liver and kidneys of alloxan-induced diabetic rats

Effects and Molecular Mechanism of Single-Nucleotide Polymorphisms of MEG3 on Porcine Skeletal Muscle Development

Influence of melatonin on glutathione system in rats skeletal muscle under alloxan induced diabetes

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