Low-intensity pulsed ultrasound promotes periodontal regeneration in a beagle model of furcation involvement

Wang, Yue; Xiao, Qingyue; Zhong, Wenjie; Zhang, Chuangwei; Yin, Yuanyuan; Gao, Xiang; Song, Jinlin

doi:10.3389/fbioe.2022.961898

Cited by 7 publications

(3 citation statements)

References 51 publications

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“…In the field of stem cell research, LIPU promotes the expansion, differentiation, and migration of mesenchymal stem cells [ 29 , 30 ], and it has been reported that LIFU-induced BBB regulation can promote neurogenesis through the activation of endogenous neural stem cells [ 31 ]. In addition, LIPU can produce different biological effects on organs, tissues, and cells, and can be applied in fracture healing, cartilage repair [ 32 ], periodontal tissue regeneration [ 33 ], and alveolar bone regeneration [ 34 ]. In human studies, transcranial FUS inhibits the brain electrical activity evoked by somatosensory evoked potentials (SEPs) induced by median nerve stimulation in the primary somatosensory area [ 35 , 36 ].…”

Section: Clinical Application Of Fus In the Treatment Of Pdmentioning

confidence: 99%

Low intensity focused ultrasound: a new prospect for the treatment of Parkinson’s disease

Zhong,

Liao,

Liu

et al. 2023

Annals of Medicine

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Background: As a chronic and progressive neurodegenerative disease, Parkinson’s disease (PD) still lacks effective and safe targeted drug therapy. Low-intensity focused ultrasound (LIFU), a new method to stimulate the brain and open the blood-brain barrier (BBB), has been widely concerned by PD researchers due to its non-invasive characteristics. Methods: PubMed was searched for the past 10 years using the terms ‘focused ultrasound’, ‘transcranial ultrasound’, ‘pulse ultrasound’, and ‘Parkinson’s disease’. Relevant citations were selected from the authors’ references. After excluding articles describing high-intensity focused ultrasound or non-Parkinson’s disease applications, we found more than 100 full-text analyses for pooled analysis. Results: Current preclinical studies have shown that LIFU could improve PD motor symptoms by regulating microglia activation, increasing neurotrophic factors, reducing oxidative stress, and promoting nerve repair and regeneration, while LIFU combined with microbubbles (MBs) can promote drugs to cross the BBB, which may become a new direction of PD treatment. Therefore, finding an efficient drug carrier system is the top priority of applying LIFU with MBs to deliver drugs. Conclusions: This article aims to review neuro-modulatory effect of LIFU and the possible biophysical mechanism in the treatment of PD, summarize the latest progress in delivering vehicles with MBs, and discuss its advantages and limitations.

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Section: Clinical Application Of Fus In the Treatment Of Pdmentioning

confidence: 99%

Low intensity focused ultrasound: a new prospect for the treatment of Parkinson’s disease

Zhong,

Liao,

Liu

et al. 2023

Annals of Medicine

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“…LIPUS has been increasingly studied in the field of tissue regeneration in recent years, and its mechanisms in bone regeneration and inflammation control have been considerably explored. Wang et al (2022b) observed through an in vivo experimental study that LPIUS promotes new bone formation in the setting of periodontitis. In addition, they found that LIPUS is also effective in reducing inflammation and promoting angiogenesis, thus providing a favorable microenvironment for periodontal regeneration.…”

Section: The Mechanisms Of Lipus In Treating Experimental Periodontitismentioning

confidence: 99%

LIPUS as a potential strategy for periodontitis treatment: A review of the mechanisms

Aimaijiang

Liu²,

Zhang³

et al. 2023

Front. Bioeng. Biotechnol.

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Periodontitis is a chronic inflammatory condition triggered by oral bacteria. A sustained inflammatory state in periodontitis could eventually destroy the alveolar bone. The key objective of periodontal therapy is to terminate the inflammatory process and reconstruct the periodontal tissues. The traditional Guided tissue regeneration (GTR) procedure has unstable results due to multiple factors such as the inflammatory environment, the immune response caused by the implant, and the operator’s technique. Low-intensity pulsed ultrasound (LIPUS), as acoustic energy, transmits the mechanical signals to the target tissue to provide non-invasive physical stimulation. LIPUS has positive effects in promoting bone regeneration, soft-tissue regeneration, inflammation inhibition, and neuromodulation. LIPUS can maintain and regenerate alveolar bone during an inflammatory state by suppressing the expression of inflammatory factors. LIPUS also affects the cellular behavior of periodontal ligament cells (PDLCs), thereby protecting the regenerative potential of bone tissue in an inflammatory state. However, the underlying mechanisms of the LIPUS therapy are still yet to be summarized. The goal of this review is to outline the potential cellular and molecular mechanisms of periodontitis-related LIPUS therapy, as well as to explain how LIPUS manages to transmit mechanical stimulation into the signaling pathway to achieve inflammatory control and periodontal bone regeneration.

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“…32,104 Therefore, large animal models such as canine and swine are needed for further in vivo validation of ASA@tHALLG nanocomposites targeting periodontal regeneration in the future. [105][106][107]…”

Section: Dovepressmentioning

confidence: 99%

A Biomimetic Smart Nanoplatform as “Inflammation Scavenger” for Regenerative Therapy of Periodontal Tissue

Chen¹,

Zhang²,

He³

et al. 2022

IJN

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The functional reconstruction of periodontal tissue defects remains a clinical challenge due to excessive and prolonged host response to various endogenous and exogenous pro-inflammatory stimuli. Thus, a biomimetic nanoplatform with the capability of modulating inflammatory response in a microenvironment-responsive manner is attractive for regenerative therapy of periodontal tissue. Methods: Herein, a facile and green design of engineered bone graft materials was developed by integrating a biomimetic apatite nanocomposite with a smart-release coating, which could realize inflammatory modulation by "on-demand" delivery of the antiinflammatory agent through a pH-sensing mechanism. Results: In vitro and in vivo experiments demonstrated that this biocompatible nanoplatform could facilitate the clearance of reactive oxygen species in human periodontal ligament stem cells under inflammatory conditions via inhibiting the production of endogenous proinflammatory mediators, in turn contributing to the enhanced healing efficacy of periodontal tissue. Moreover, this system exhibited effective antimicrobial activity against common pathogenic bacteria in the oral cavity, which is beneficial for the elimination of exogenous pro-inflammatory factors from bacterial infection during healing of periodontal tissue. Conclusion:The proposed strategy provides a versatile apatite nanocomposite as a promising "inflammation scavenger" and propels the development of intelligent bone graft materials for periodontal and orthopedic applications.

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Low-intensity pulsed ultrasound promotes periodontal regeneration in a beagle model of furcation involvement

Cited by 7 publications

References 51 publications

Low intensity focused ultrasound: a new prospect for the treatment of Parkinson’s disease

Low intensity focused ultrasound: a new prospect for the treatment of Parkinson’s disease

LIPUS as a potential strategy for periodontitis treatment: A review of the mechanisms

A Biomimetic Smart Nanoplatform as “Inflammation Scavenger” for Regenerative Therapy of Periodontal Tissue

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