Low-Intensity Shockwave Therapy for Erectile Dysfunction

Rizk, Paul; Krieger, Jordan R.; Kohn, Taylor P.; Pastuszak, Alexander W.

doi:10.1016/j.sxmr.2018.01.002

Cited by 35 publications

(31 citation statements)

References 20 publications

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“…It could be explained by the fact that the improvement in QOL makes a favorable difference in sexual function, which is reduced notably in patients with CP/CPPS . What's more, the local application of shock waves has significant effects on erectile function . In regard to side effects, though all the trials recorded them during the treatment period, only one trial reported side effects (1.22 [0.59, 2.51]), in which dizziness, gastrointestinal complaint, and postural hypotension were noted and no anesthetic deemed necessary.…”

Section: Discussionmentioning

confidence: 99%

“…34 What's more, the local application of shock waves has significant effects on erectile function. 35 In regard to side effects, though all the trials recorded them during the treatment period, only one trial 20 reported side effects (1.22 [0.59, 2.51]), in which dizziness, gastrointestinal complaint, and postural hypotension were noted and no anesthetic deemed necessary. These further confirm the safety of Li-ESWT for CP/ CPPS.…”

Section: Discussionmentioning

confidence: 99%

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Efficacy of low‐intensity extracorporeal shock wave therapy for the treatment of chronic prostatitis/chronic pelvic pain syndrome: A systematic review and meta‐analysis

Yuan

Zhang

et al. 2019

Neurourology and Urodynamics

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Aims Low‐intensity extracorporeal shock wave therapy (Li‐ESWT) has been applied in urolithiasis and some chronic diseases. We performed a systematic review and meta‐analysis to assess the efficacy of Li‐ESWT for the treatment of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). Methods A comprehensive search of MEDLINE, Web of Science, EMBASE, and the Cochrane Library to January 6, 2019 was performed for randomized controlled trials (RCTs) reporting on patients with CP/CPPS treated with Li‐ESWT compared with the sham group. Outcomes were evaluated based on the National Institutes of Health Chronic Prostatitis Symptom Index (NIH‐CPSI). The quality assessment of included studies was performed by the Cochrane System. Results Six publications involving five RCTs with 280 patients were assessed in this review. NIH‐CPSI total score, pain domain and quality of life (QOL) were significantly better in the Li‐ESWT group than those in the control group at the endpoint (P < 0.00001, P = 0.003, and P < 0.00001), 4 weeks (P < 0.00001, P = 0.0002 and P < 0.00001) and 12 weeks (P < 0.00001, P < 0.00001, and P = 0.0002) after the treatment. For urinary score, significant difference existed at 12 weeks after the treatment (P = 0.006). At 24 weeks after treatment, there was no significant difference between the two groups in NIH‐CPSI total score (P = 0.26), pain domain (P = 0.32), urinary score (P = 0.07), and QOL (P = 0.29). Conclusions Li‐ESWT showed great efficacy for the treatment of CP/CPPS at the endpoint and during the follow‐up of 4 and 12 weeks, though the efficacy of 24‐week follow‐up was not significantly different due to insufficient data. Generally, Li‐ESWT is a promising minimal invasive method for the treatment of CP/CPPS.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Efficacy of low‐intensity extracorporeal shock wave therapy for the treatment of chronic prostatitis/chronic pelvic pain syndrome: A systematic review and meta‐analysis

Yuan

Zhang

et al. 2019

Neurourology and Urodynamics

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“…Found that LIESWT are good for penile tissue regenerating by mesenchymal stem cells activation andnerve regeneration (via Schwann cells activation), and vessels, with the consequent release of proangiogenetic growth factors. In addition, LIESWT also enhance erectile function via nitric oxide/cGMPnondependent mechanisms.Rizk et al [26]included randomized controlled trials, meta-analyses, and select singlearm studies on the use of Li-ESWT in the treatment of at least mild ED, with some data supporting efficacy in moderate-tosevere ED also demonstrated some benefit in specific subsets of men with vasculogenic ED (including patients with DM). Kalyvianakis et al [27] assessed the efficacy and safety of 6and 12-treatment sessions within a 6-week treatment period and also investigated the effect of repeat treatment after a 6month period in a 2-phase study in patients with vasculogenic ED.…”

Section: Discussionmentioning

confidence: 99%

Change in Peak Systolic Velocity of Cavernous Artery in Response to Low Intensity Shock Waves Therapy in Diabetic Polyneuropathy Patients with Erectile Dysfunction: A Randomized Controlled Trial

2020

J. Environ. Treat. Tech.

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Although several reports have documented the subjective improvement of erectile function after low-intensity extracorporeal shockwave therapy (LI-ESWT) in patients with vasculogenic erectile dysfunction (ED), objective assessment data of penile hemodynamics are lacking. The aim of this research is to detect the Change in peak systolic velocity of cavernous artery in response to low intensity shock waves therapy in diabetic patients with erectile dysfunction. This study is a randomized controlled trial. Overall forty male individuals with mean age (48.6±5.52 years)who have erectile dysfunction after diabetes were equally divided into two separate groups. 1st Group received low intensity extracorporeal shock wave therapy (ESWT). 2nd Group received shame therapy by put head of shock wave while machine is turned off. 1st Group received low intensity extracorporeal shock wave with the following parameters: - 3000 SWs (energy intensity of 0.09mJ/mm2) to each of five different sites of application: three areas along the penile shaft and two areas at the crural level for six weeks as a total period of treatment. Measurements of peak systolic velocity by penile duplex were performed before the treatment and after 3months. There were change in peak systolic velocity of the right and left cavernous arteries were low at baseline, indicating arterial insufficiency. After treatment, PSV significantly in the two groups; however, the post-treatment PSV was significantly higher in the SW group compared to the PFE group (p < 0.001, for both arteries).LIESWT is lead to significant changes in patients suffering from erectile dysfunction after diabetes as evidenced by increase in the peak systolic volume of the both right and left cavernous arteries of the shock wave group.

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“…In spite of the unambiguous symptomatic orientation of the action mechanism of PDE-5 not only doesn't demonstrate absolute eff ectiveness, but also, due to the marketing image of the "universal remedy", reduce patient's interest in pathogenetic and etiotropic therapy. This leads to the acute demand to consider new, primarily bio-and physiotherapeutic options for the treatment of EDVO [2,[4][5][6].…”

mentioning

confidence: 99%

“…In the fi rst two decades of the twenty-fi rst century, cellular and modern physiotherapeutic technologies should be distinguished, by not only its fundamental progress and evolution, but also by overcoming the mistrust of clinicians and entering in to clinical practice as routine therapeutic procedures. With regard to the problem of EDVO, the proven pathogenetic eff ect has been shown by methods of vector (gene) therapy, stem cells and local platelet-rich plasma therapy (PRP-therapy), modern physiotherapeutic techniques such as low-intensity pulsed ultrasound and low-intensity extracorporeal shock-wave therapy (LESWT) [1, [4][5][6].…”

mentioning

confidence: 99%

The Experience of Combined Application of Platelet-Rich Plasma Therapy and Shock-Wave Therapy in Treatment of Erectile Dysfunction of Vascular Origin

Zasieda

Solomianyi²,

Shykhaliiev³

2018

UJMH

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In order to compare the clinical eff ect of platelet rich plasma-therapy and local negative pressure-therapy on the background of pharmacotherapy with Icariin and combined platelet rich plasma-therapy in combination with shock-wave therapy and vacuum device therapy on the background of pharmacotherapy with Icariin in the treatment of erectile dysfunction of arterial and arterial-venous origin, 50 patients of the «Men’s Health» Clinic (Kiev) were examined with using clinical, laboratory and sonographic methods. Based on the results of the study, the high eff ectiveness of platelet rich plasma-therapy, shock-wave therapy and vacuum device -therapy and Icariin combinationsuse in the arterial and arterial-venous erectile dysfunction therapy in comparison with platelet rich plasma-therapy and vacuum device therapy and Icariin. According to our data intracavernosus activation of plate-cells was conducted by shock-wave method in a first time ever.

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Low-Intensity Shockwave Therapy for Erectile Dysfunction

Cited by 35 publications

References 20 publications

Efficacy of low‐intensity extracorporeal shock wave therapy for the treatment of chronic prostatitis/chronic pelvic pain syndrome: A systematic review and meta‐analysis

Efficacy of low‐intensity extracorporeal shock wave therapy for the treatment of chronic prostatitis/chronic pelvic pain syndrome: A systematic review and meta‐analysis

Change in Peak Systolic Velocity of Cavernous Artery in Response to Low Intensity Shock Waves Therapy in Diabetic Polyneuropathy Patients with Erectile Dysfunction: A Randomized Controlled Trial

The Experience of Combined Application of Platelet-Rich Plasma Therapy and Shock-Wave Therapy in Treatment of Erectile Dysfunction of Vascular Origin

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