Low-level arsenic in drinking water and risk of incident myocardial infarction: A cohort study

Monrad, Maria; Ersbøll, Annette Kjær; Sørensen, Mette; Baastrup, Rikke; Hansen, Birgitte; Gammelmark, Anders; Tjønneland, Anne; Overvad, Kim; Raaschou-Nielsen, Ole

doi:10.1016/j.envres.2017.01.028

Cited by 81 publications

(48 citation statements)

References 30 publications

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“…BRT statistical modeling (Elith et al, ), a type of machine‐learning model, was applied to two regions of Minnesota with complex glacial geology and known to have a high likelihood of elevated As concentrations in drinking water aquifers (20 to 40% elevated As). For the purpose of this paper elevated is defined as ≥10 μg/L, the current EPA MCL and World Health Organization standard, even though chronic exposure to As at lower concentration can be detrimental (Almberg et al, ; Bulka et al, ; Monrad et al, ). Using the model, we mapped the probability of elevated As for common drinking water well depths and other common domestic well construction attributes in the two study regions.…”

Section: Methodsmentioning

confidence: 99%

Predicting geogenic Arsenic in Drinking Water Wells in Glacial Aquifers, North‐Central USA: Accounting for Depth‐Dependent Features

Erickson

Elliott

Christenson

et al. 2018

Water Resources Research

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Chronic exposure to arsenic (As) via drinking groundwater is a human health concern worldwide. Probabilities of elevated geogenic As concentrations in groundwater were predicted in complex, glacial aquifers in Minnesota, north-central USA, a region that commonly has elevated As concentrations in well water. Maps of elevated As hazard were created for depths typical of drinking water supply and with well construction attributes common for domestic wells. Conventional variables describing aquifer properties and materials, position on the hydrologic landscape, and soil geochemistry were among the most influential for predicting the probability of elevated As. We also found that certain well construction attributes were influential in predicting As hazard. Smaller distances between the top of the well screen and overlying aquitard (proximity) and shorter well screen lengths were each associated with higher probabilities of elevated As. Influential predictor variables, which are either mapped across the region or are well construction attributes, are proxies in the model for measurable physical or geochemical causes of elevated As (e.g., redox condition, till or aquifer sediment chemistry, and water chemistry), which are not mapped across the region. Our setting shares some important characteristics with deltaic and other high-As aquifers in Southeast Asia: late Quaternary age, complex layering of coarse-and fine-grained materials, low-As sediment concentrations, and geochemical controls on As mobilization. Translating three-dimensional geologic and geochemical understanding of As mobility to quantifiable variables for modeling with powerful, flexible statistical tools could improve predictions and help identify safer groundwater supply options in the USA, Southeast Asia, and elsewhere.Plain Language Summary This study demonstrates that certain well construction attributes are influential in predicting arsenic (As) concentrations in drinking water wells. Smaller distances between the top of the well screen and overlying aquitard, and shorter well screen lengths, were each associated with higher probabilities of elevated As. Chronic exposure to As via drinking groundwater is a human health concern worldwide, and Minnesota, USA, commonly has elevated As concentrations in well water. This study describes a new, novel, and important finding from an As probability model: Controllable well construction choices (not just location or depth) influence As concentrations in drinking water from wells.

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Section: Methodsmentioning

confidence: 99%

Predicting geogenic Arsenic in Drinking Water Wells in Glacial Aquifers, North‐Central USA: Accounting for Depth‐Dependent Features

Erickson

Elliott

Christenson

et al. 2018

Water Resources Research

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“…where Q is the quantity of arsenite adsorbed per unit of mass of zeolite (mg g −1 ), Q max is the adsorption capacity (mg g −1 ), ε is the Polanyi potential, C 0 and C e are the initial and equilibrium arsenite concentration (mg L −1 ), k is a constant related to adsorption energy and b is the Langmuir constant. The Van't Hoff's Equations (6) and (7) are useful to determine the thermodynamic parameters. It assumes that Langmuir constant b and enthalpy adsorption are function of the specific pair of adsorbent ions on the active site and on the temperature [47].…”

Section: Effect Of Temperature Fe-modified W Zeolite Dose and As (Iimentioning

confidence: 99%

“…Diabetes has been investigated in arsenic-exposed Mexican populations by Del Razo et al who found that the prevalence of diabetes was associated with arsenic in drinking water and with the concentration of dimethylarsenite in urine, linking the risk of diabetes to the production of one of the most toxic metabolites of inorganic arsenic [6]. Even low arsenite concentrations (0.002-0.025 mg L −1 ) in drinking water might increase the risk of myocardial infarction [7] and affect the female fecundity [8]. Cheng et al found a relation between exposure to arsenic and chronic kidney disease in Taiwan [9].…”

Section: Introductionmentioning

confidence: 99%

Adsorption of Aqueous As (III) in Presence of Coexisting Ions by a Green Fe-Modified W Zeolite

Medina-Ramírez

Gamero‐Melo²,

Ruiz-Camacho

et al. 2019

Water

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The high toxicity of arsenite and the difficulty to remove it is one of the main challenges for water treatment. In the present work the surface of a low cost zeolite was modified by chemical treatment with a ferrous chloride to enhance its arsenite adsorption capacity. The effect of pH, ions coexistence, concentration, temperature and dosage was studied on the adsorption process. Additionally, the Fe-modified W zeolite was aged by an accelerated procedure and the regeneration of the exhausted zeolite was demonstrated. The Fe-modified W zeolite was stable in the pH range of 3 to 8 and no detriment to its arsenite removal capacity was observed in the presence of coexisting ions commonly found in underground water. The studies showed that the adsorption of As (III) on Fe-modified W zeolite is a feasible, spontaneous and endothermic process and it takes place by chemical bonding. The exhausting process proved the adsorption of 0.20 mg g−1 of As (III) by the Fe-modified W zeolite and this withstand at least five aging cycles without significant changes of its arsenite adsorption capacity. Fe-modified W zeolite prepared from fly ash might be a green and low-cost alternative for removal of As (III) from groundwater.

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“…9, 10, 11 Studies at low-moderate levels of arsenic exposure, more similar to those occurring in U.S. populations, are lacking. In large cohort studies in Denmark 12 and Italy, 13 low-moderate levels of arsenic exposure were associated with higher lifetime risk of myocardial infarction and deaths from chronic diseases respectively. We are aware of no prospective studies evaluating the association between arsenic and carotid vascular disease.…”

Section: Introductionmentioning

confidence: 97%

Chronic arsenic exposure and risk of carotid artery disease: The Strong Heart Study

Mateen

Grau-Pérez

Pollak

et al. 2017

Environmental Research

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Background Inorganic arsenic exposure from naturally contaminated groundwater is related to vascular disease. No prospective studies have evaluated the association between arsenic and carotid atherosclerosis at low-moderate levels. We examined the association of long-term, low-to-moderate inorganic arsenic exposure with carotid arterial disease. Methods American Indians, 45 to 74 years old, in Arizona, Oklahoma, and North and South Dakota had arsenic concentrations (sum of inorganic and methylated species, μg/g urine creatinine) measured from baseline urine samples (1989-1991). Carotid artery ultrasound was performed in 1998-1999. Vascular disease was assessed by the carotid intima media thickness (CIMT), the presence of atherosclerotic plaque in the carotid, and by the number of segments containing plaque (plaque score). Results 2402 participants (mean age 55.3 years, 63.1% female, mean body mass index 31.0kg/m2, diabetes 45.7%, hypertension 34.2%) had a median (interquintile range) urine arsenic concentration of 9.2 (5.00, 17.06) μg/g creatinine. The mean CIMT was 0.75 mm. 64.7% had carotid artery plaque (3% with >50% stenosis). In fully adjusted models comparing participants in the 80th vs. 20th percentile in arsenic concentrations, the mean difference in CIMT was 0.01 (95% confidence interval (95%CI): 0.00, 0.02) mm, the relative risk of plaque presence was 1.04 (95%CI: 0.99, 1.09), and the geometric mean ratio of plaque score was 1.05 (95%CI: 1.01, 1.09). Conclusions Urine arsenic was positively associated with CIMT and increased plaque score later in life although the association was small. The relationship between urinary arsenic and the presence of plaque was not statistically significant when adjusted for other risk factors. Arsenic exposure may play a role in increasing the severity of carotid vascular disease.

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Low-level arsenic in drinking water and risk of incident myocardial infarction: A cohort study

Cited by 81 publications

References 30 publications

Predicting geogenic Arsenic in Drinking Water Wells in Glacial Aquifers, North‐Central USA: Accounting for Depth‐Dependent Features

Predicting geogenic Arsenic in Drinking Water Wells in Glacial Aquifers, North‐Central USA: Accounting for Depth‐Dependent Features

Adsorption of Aqueous As (III) in Presence of Coexisting Ions by a Green Fe-Modified W Zeolite

Chronic arsenic exposure and risk of carotid artery disease: The Strong Heart Study

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