Low‐level increases in serum C‐reactive protein are present in early osteoarthritis of the knee and predict progressive disease

Abstract

Objective. To examine the role of low-grade inflammation in the etiology and progression of early osteoarthritis (OA) of the knee.Methods. We used a new, high-sensitivity, automated monoclonal antibody immunoassay for the classic acute-phase protein, C-reactive protein (CRF'), in serum. Anteroposterior radiographs of the knee with weight bearing were obtained on 845 women (ages 44-67) on entry into a population-based study of OA in Chingford, North London. In those defined radiologically as "cases," the knee radiographs were repeated after 4 years.Results. Levels of CRP were higher in 105 women with knee OA defined radiologically as KellgrenLawrence grade 2+ (median 2.4 mglliter, interquartile range [IQR] 1.0-5.1), compared with 740 women without OA (median 0.7 mglliter, IQR 0.3-1.8) (P < 0.001).Median levels of CRP were higher in the 31 women whose disease progressed at least 1 Kellgren-Lawrence grade (median 2.6 mglliter, IQR 1.9-4.6), compared with the 39 whose disease did not (median 1.3 mglliter, IQR 0.6-2.4) (P = 0.006) . The significance of these differences persisted after adjustment for age, weight, height, smoking, knee pain, or injury. Classifying disease by the presence of joint space narrowing or osteophytes alone produced similar results.

Role of Soluble Vascular Cell Adhesion Molecule-1 in Knee Osteoarthritis among Postmenopausal Women

“…The mechanism through which estrogen decreases cytokine induced VCAM-1 production by inhibition of NF-κβ, AP-1 and GATA transcription factors. [30] In this study the serum level of CRP was also found significantly high in postmenopausal women with symptoms of knee osteoarthritis as compared to control which is in consistent with the study of Spector et al who reported modestly but significant increase of CRP level in women with early stage of knee osteoarthritis [14] . CRP is an acute phase protein, which reflects a measure of the acute-phase response.…”

“…[9][10][11][12] ] C-reactive protein (CRP) serving as a marker for systemic inflammation, several studies showing a relationship between serum CRP levels and osteoarthritis of the knee. [13][14][15] Although, CRP is not taken as an optimal marker for inflammation in osteoarthritis; other putative markers have been associated with some osteoarthritis phenotypes. These include proinflammatory cytokines, cell adhesion molecules and adiponectin.…”

Normalization of Varus/Valgus Deformities in Osteoarthritis by External Application of Phytoconstituents: Confirmed With Anatomical Observations and Biochemical Profiles and Radiological Images

“…In the present study, biochemical parameters such as C-reactive protein (CRP), muscle creatine phosphokinase (CPK mm) and aldolase-A were recorded separately followed by the methods of other researchers [26][27][28]. The biochemical parameters were done from blood/serum, collected individually for all males and females.…”

Association of C-reactive protein positivity among groups of patients with knee osteoarthritis in Erbil

“…We did not found any relation between age and positive CRP in our patients that's similar to Pearle et al 22 studies, this is against many epidemiological studies. 25 Several studies have reported relationships between CRP and various features of KOA, in Spector et al 26 and Sturmer et al 24 studies a population based, cross sectional study observed increased CRP values in women with radiographically defined knee OA. In contrast, our results showed no significant relationship between C-reactive protein and sex.…”