Low-level laser therapy (670 nm) on viability of random skin flap in rats

Bossini, Paulo Sérgio; Fangel, Renan; Habenschus, Rafael Malfará; Rennó, Ana Cláudia Muniz; Benze, Benedito Galvão; Zuanon, José A.; Neto, Carlos Benatti; Parizotto, Nivaldo Antônio

doi:10.1007/s10103-008-0551-5

Cited by 49 publications

(58 citation statements)

References 25 publications

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“…In the present study, the increase in survival observed in irradiated skin flaps agrees with previous studies [19][20][21][22] , except for Smith, 9 who did not find any significant effect in the use of laser therapy.…”

Section: G1 (%) G2 (%) G3 (%) G4 (%)supporting

confidence: 93%

“…The studies found in the literature dealing with this topic used lasers operating at wavelengths of 632.8 5,7,9 , 660 19 and 830 nm 3,4,6,8 , and emitting continuous light (Table 3). In the present study, the increase in survival observed in irradiated skin flaps agrees with previous studies [19][20][21][22] , except for Smith, 9 who did not find any significant effect in the use of laser therapy.…”

Section: G1 (%) G2 (%) G3 (%) G4 (%)mentioning

confidence: 99%

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The effects of different doses of 670 nm diode laser on skin flap survival in rats

et al. 2012

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PURPOSE: To investigate the effects of different low-level laser therapy (LLLT) doses on random skin flap rats. METHODS: Forty Wistar rats were randomly divided in four groups. The control group (CG) was not irradiated. The experimental groups were irradiated with a diode laser 670 nm with different energies per point: group 2 (G2) with 0.06 J; group 3 (G3) 0.15 J and group 4 (G4) 0.57 J. The three groups were irradiated in 12 equally distributed points in the cranial skin flap portion. They were submitted to the irradiation during the immediate, first and second postoperative days. The necrosis area was evaluated in the seventh postoperative day. RESULTS: The CG shows 49.35% of necrosis area in the skin flap; G2, 39.14%; G3, 47.01% and G4, 29.17% respectively. There was a significantly difference when G4 was compared with CG`s skin flap necrosis area. CONCLUSION: The low-level laser therapy diode 670 nm with 0.57 J energy per point increases the survival in randomic skin flap rats.

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Section: G1 (%) G2 (%) G3 (%) G4 (%)supporting

confidence: 93%

Section: G1 (%) G2 (%) G3 (%) G4 (%)mentioning

confidence: 99%

The effects of different doses of 670 nm diode laser on skin flap survival in rats

et al. 2012

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“…33,34 Last, neurogenesis and neuroplasticity (synaptogenesis) may both be other mechanisms that contribute to the beneficial effects of tLLLT in the brain. 35 These processes are initiated by the increase in neurotrophin expression as in brain-derived neurotrophic factor (BDNF) and nerve growth factor.…”

Section: Mechanisms Of Tllltmentioning

confidence: 99%

Transcranial Low-Level Laser (Light) Therapy for Brain Injury

Thunshelle

Hamblin

2016

Photomedicine and Laser Surgery

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Background: Low-level laser therapy (LLLT) or photobiomodulation (PBM) is a possible treatment for brain injury, including traumatic brain injury (TBI). Methods: We review the fundamental mechanisms at the cellular and molecular level and the effects on the brain are discussed. There are several contributing processes that have been proposed to lead to the beneficial effects of PBM in treating TBI such as stimulation of neurogenesis, a decrease in inflammation, and neuroprotection. Both animal and clinical trials for ischemic stroke are outlined. A number of articles have shown how transcranial LLLT (tLLLT) is effective at increasing memory, learning, and the overall neurological performance in rodent models with TBI. Results: Our laboratory has conducted three different studies on the effects of tLLLT on mice with TBI. The first studied pulsed against continuous laser irradiation, finding that 10 Hz pulsed was the best. The second compared four different wavelengths, discovering only 660 and 810 nm to have any effectiveness, whereas 732 and 980 nm did not. The third looked at varying regimens of daily laser treatments (1, 3, and 14 days) and found that 14 laser applications was excessive. We also review several studies of the effects of tLLLT on neuroprogenitor cells, brain-derived neurotrophic factor and synaptogenesis, immediate early response knockout mice, and tLLLT in combination therapy with metabolic inhibitors. Conclusions: Finally, some clinical studies in TBI patients are covered.

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“…The presence of myofibroblasts creates a centripetal contraction from the edges of the burn lesion. Myofibroblast apoptotic cell death may promote lesion contraction more than 50% of the original size [26]. Photomicrographs showed faster wound contraction in the group on day 14 compared to untreated scald wounds.…”

Section: Discussionmentioning

confidence: 90%

“…This study shows that low intensity laser therapy has a remarkable effect that inhibits TNF-α and IL-6 levels along with the reduction of edema and inflammatory responses. The action of low intensity laser therapy is based on the light absorption in thermally injured skin tissue, which will generate proliferation in cellular metabolism [26,29]. LLLT has been shown to accelerate the acute inflammatory process and tissue repair of the wound [30,31].…”

Section: Discussionmentioning

confidence: 99%

Anti-inflammatory effects of low-level laser in burn wound models in rats

Kim

2017

PTRS

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Objective: The anti-inflammatory effects of low-level laser in burn wound model in rats were investigated. Design: Randomized controlled trial. Methods: The rats were assigned to three experimental groups. Group I received second-degree burn wounds; Group II received dressing film and low-level laser (1.2 J/cm 2 ) treatment after a burn wound; Group III received dressing film and low-level laser (2.3 J/cm 2 ) treatment after a burn wound. After inducing a deep second-degree burn wound, the wound was observed every day and the burn area diameter and retraction quantification at 1, 7, and 14 days were evaluated. Low-level laser was investigated on hematological parameters after 14 days. Effects of low-level laser on the inflammatory cytokines (tumor necrosis factor-α [TNF-α] and interleukin-6 [IL-6]) concentrations in the serum were evaluated using immunosorbent assay kits. Results: Group III showed a significant difference in wound size on days 7 and 14 compared to Group I (p<0.05). Group II showed a significant difference in wound size on day 14 compared to Group I (p<0.05). For wound contraction percentage, both laser therapy treatment groups showed a significant difference compared with Group I (p<0.05). There was also a significant difference in wound contraction percentage in Group III compared to Group II (p<0.05). Compared with the model control group, decreased TNF-α and IL-6 levels in the serum was observed at 14 days after burn wound induction. Conclusions:The results of this study suggest that low-level laser therapy can assist in burn wound healing, which might be associated with decreased concentrations of TNF-α and IL-6 related proinflammatory cytokines.

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Low-level laser therapy (670 nm) on viability of random skin flap in rats

Cited by 49 publications

References 25 publications

The effects of different doses of 670 nm diode laser on skin flap survival in rats

The effects of different doses of 670 nm diode laser on skin flap survival in rats

Transcranial Low-Level Laser (Light) Therapy for Brain Injury

Anti-inflammatory effects of low-level laser in burn wound models in rats

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