Low level laser therapy (Photobiomodulation therapy) for breast cancer-related lymphedema: a systematic review

Baxter, GD; Liu, Lizhou; Petrich, Simone; Gisselman, Angela Spontelli; Chapple, Cathy; Anders, Juanita J.; Tumilty, Steve

doi:10.1186/s12885-017-3852-x

Cited by 92 publications

(72 citation statements)

References 52 publications

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“…In this context, photobiomodulation (PBM) is widely known for its therapeutic benefits in the protection and regeneration of tissues [18][19][20][21][22][23]. Studies have demonstrated that PBM can reduce pain and inflammation [23][24][25], improve cancer management [26], and stimulate healing and tissue repair [20][21][22][27][28][29][30][31]. PBM is defined by the use of visible light to stimulate biological functions in a non-thermal and non-cytotoxic manner.…”

Section: Introductionmentioning

confidence: 99%

Management of otitis externa with an led-illuminated gel: a randomized controlled clinical trial in dogs

et al. 2020

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Background: Canine otitis externa is a painful condition which can be challenging to treat due to difficulties in the administration of otic medication. This can be due to lack of owner compliance in the application of ear drops or due to the resentment that some dogs demonstrate when attempts are made to administer topical medication into a sensitive ear canal. The aim of the study was to assess the efficacy of a topical LED-illuminated gel (LIG) in canine otitis externa in comparison to standard of care therapy. Dogs with spontaneous otitis externa were randomly allocated in three groups: groups QW received LIG once weekly; BW received LIG twice weekly; group C received enrofloxacin and silver sulfadiazine twice daily. LIG consists of a topical application of a gel containing chromophores that, when illuminated by a LED lamp, re-emit fluorescent light which can stimulate physiological responses, promoting healing and controlling bacteria. The evaluation protocol (T 0 to T 5) considered clinical assessment (OTIS-3-index-scoring-system; pruritus-severity-scale; pain-severity-score; aural temperature), cytological scoring system, quali-quantitative bacteriologic assessment. Results: All groups (QW, n = 21; BW, n = 23; C, n = 20) showed improvement during the study (QW: P < 0.02 for cytological and pain scores, P < 0.003 for bacteriologic assessment, P < 10 − 4 for pruritus, total OTIS-3 and temperature assessments; BW: P < 10 − 4 for all clinical, cytological and bacteriologic assessments; C: P < 0.02 for all clinical and cytological assessments, P < 10 − 4 for bacteriologic assessment). The highest clinical score reduction occurred in Group BW (P < 0.014 in T 3 ; P < 0.001 in T 4 and P < 10 − 4 in T 5). BW reached the clinically relevant effect level at T 3 (− 3.26 ± 1.21 levels), QW reached it at T 4 (− 3.24 ± 0.99), C did not reach it. No differences between groups were seen in the reduction of CFU/mL (T 0-T 5). Conclusions: All treatment groups showed a positive clinical effect. LIG administered twice-a-week was the most favourable protocol of the study. LIG may be considered beneficial in the management of canine otitis externa; it seems to be effective in controlling the clinical condition, including the signs of inflammation and local pain, the bacterial growth, and it may help increasing treatment compliance.

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Section: Introductionmentioning

confidence: 99%

Management of otitis externa with an led-illuminated gel: a randomized controlled clinical trial in dogs

et al. 2020

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“…The review indicated strong evidence for limb circumference/volume reduction over sham treatment, moderate evidence for short-term pain relief over sham laser treatment, and limited evidence for limb swelling over no treatment. 26 Mahram and Rajabi 25 reported that LLLT in a patient with LEL had reduced edema, but it did not result in a reduction in extremity volume. In our study, we found a significant decrease in both edema and extremity volume with LLLT.…”

Section: Discussionmentioning

confidence: 99%

“…Treatment was applied in the supine position with leg abduction and external rotation. 26 The LLLT was administered every day for the first 4 weeks and then 2 days a week for 8 weeks.…”

Section: Interventionsmentioning

confidence: 99%

A Randomized Controlled Trial Comparing Platelet-Rich Plasma, Low-Level Laser Therapy, and Complex Decongestive Physiotherapy in Patients with Lower Limb Lymphedema

Akgül

Tarakçı

Arman

et al. 2020

Lymphatic Research and Biology

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Background: Platelet-rich plasma (PRP) is an autologous concentrated preparation of platelets characterized by lymphangiogenetic and tissue-repairing effects. Although PRP has been safely used in many different fields, there is no clinical study regarding the use of PRP in lymphedema treatment in humans. We assessed the clinical outcomes of PRP in patients with lower extremity lymphedema (LEL) in a randomized controlled trial. Methods and Results: Patients with secondary LEL were randomly allocated to one of three groups consisting of treatment with PRP with complex decongestive physiotherapy (PRP+CDP group), low-level laser therapy with CDP (LLLT+CDP group), and only CDP (CDP group). Assessment of Lymphedema Quality of-Life Questionnaire (LYMQOL) for health-related quality of life, lower-extremity-circumference (LEC) for edema, tissue dielectric constant (TDC) for extremity volume, 6-minute walking test (6MWT) for functional capacity, and numeric rating scale (NRS) scoring for extremity fullness were evaluated both before and after treatment. Forty-five patients (68.8% female) with mean age 40.84-15.81 years were included in the study. Significant differences in LYMQOL, LEC, NRS, and TDC values both before and after treatment were found in all groups; however, there were no statistically significant difference in values between the three groups. In the PRP+CDP group, LYMQOL values had a larger effect size than the other two groups. Significant differences in 6MWT values both before and after treatment were found in PRP+CDP and LLLT+CDP groups; however, there was no statistically significant difference in the CDP group. Conclusion: This is the first clinical study to evaluate the usage of PRP in patients with secondary LEL. PRP might be an additional treatment option of lymphedema management; however, more clinical trials in humans are needed to yield more evidence in the usage of PRP in patients with lymphedema.

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“…There is no cure for lymphedema; however, there are several options for treatment aiming to control symptoms and reduce recurrent rate, using complete decongestive therapy (CDT), and exercise therapy [8,9]. Additional management options include pneumatic pumps [10], low-level laser therapy [11], and kinesiotaping [12].…”

Section: Introductionmentioning

confidence: 99%

Lymphedema Rehabilitation: Provision and Practice Patterns among Service Providers: National Survey

Omar¹,

Aldhwayan

et al. 2019

Preprint

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Background: Information on the current practices and quantification of lymphedema service may be beneficial to promote and improve health care system. Therefore, this study aimed to describe characteristics of lymphedema practitioners, and lymphedema patients’ profile, and provide a comprehensive picture of lymphedema service provision in Saudi Arabia. Methods: A cross-sectional study involved use of an online survey. The survey questionnaires included information about demographic and professional characteristics of lymphedema practitioners, lymphedema profile, questions on the services provided, and perceived barriers in providing a service. Results: Eighteen lymphedema practitioners (37.50%) responded to the survey. They worked in the major cities: Riyadh (78%), Jeddah (17%), and Dammam (5%), and most of them working in public hospitals (67%). Respondents typically had a background in physical or occupational therapy and had completed a basic training course on lymphedema treatment and management. About 75% of patients seen by practitioners had secondary lymphedema, 47% with breast cancer-related lymphedema. On average 72%, practitioners provide a “comprehensive” lymphedema services. The average number of lymphedema practitioners per service is 2.67. The perceived barriers reported included an inadequate number of certified therapists (100%), difficulties with transportation and lack of financial support (each =72%), and limited space for lymphedema practice/management (89%). Conclusion: The results suggest that lymphedema practitioners provide a reasonable, but not the optimal, services for lymphedema patients. The service provision is still limited and inequities. Therefore, more staffing is required to promote awareness of the condition and related services, improve referral and care coordination, and enhancing geographical and multidisciplinary coordination of the service.

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Low level laser therapy (Photobiomodulation therapy) for breast cancer-related lymphedema: a systematic review

Cited by 92 publications

References 52 publications

Management of otitis externa with an led-illuminated gel: a randomized controlled clinical trial in dogs

Management of otitis externa with an led-illuminated gel: a randomized controlled clinical trial in dogs

A Randomized Controlled Trial Comparing Platelet-Rich Plasma, Low-Level Laser Therapy, and Complex Decongestive Physiotherapy in Patients with Lower Limb Lymphedema

Lymphedema Rehabilitation: Provision and Practice Patterns among Service Providers: National Survey

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