Low-Level Laser Therapy Prevents Treadmill Exercise-Induced Progression of Arthrogenic Joint Contracture Via Attenuation of Inflammation and Fibrosis in Remobilized Rat Knees

Kaneguchi, Akinori; Ozawa, Junya; Minamimoto, Kengo; Yamaoka, Kaoru

doi:10.1007/s10753-018-0941-1

Cited by 22 publications

(18 citation statements)

References 37 publications

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“…These results indicate that remobilization improves myogenic contracture, but aggravates arthrogenic contracture oppositely. Although immobilization-induced arthrogenic contracture is not improved by remobilization (Kaneguchi et al 2017, Kaneguchi et al 2018a, Kaneguchi et al 2018b, Kaneguchi et al 2019, Trudel et al 2014, arthrogenic contracture in intra-articular adhesion model using joint immobilization with intraarticular injury partially recovers after remobilization (Baranowski et al 2018). These findings suggest that arthrogenic contracture attributed to intra-articular injury may be variable in contrast with immobilization only.…”

Section: Discussionmentioning

confidence: 87%

“…After three weeks, the fixation device was removed and rats in the RM and RM+M groups were allowed to recover for one week (remobilization). It is known that one week of remobilization following three weeks of immobilization induces fibrotic reactions in the joint capsule and arthrogenic contracture progression (Kaneguchi et al 2017, Kaneguchi et al 2018a, Kaneguchi et al 2018b, Kaneguchi et al 2019. Rats in the IM group were analyzed immediately after removal of the fixator and represented data from immobilization without remobilization.…”

Section: Joint Immobilization and Remobilizationmentioning

confidence: 99%

“…In contrast, arthrogenic factors largely contribute to severe joint contracture induced by prolonged (over four weeks) immobilization, and recovery by remobilization is not expected in these cases (Trudel et al 2014). Arthrogenic contracture also further progresses during remobilization following short-term (within three weeks) immobilization (Kaneguchi and Ozawa 2017, Kaneguchi et al 2017, Kaneguchi et al 2018a, Kaneguchi et al 2018b, Kaneguchi et al 2019, Trudel et al 2014. To avoid irreversible joint contracture, arthrogenic contracture should therefore be targeted.…”

Section: Introductionmentioning

confidence: 99%

“…For example, administration of decorin, which suppresses bioactivity of cell adhesion, as well as fibrotic regulators, such as transforming growth factor-beta, can improve restricted joint motion in the rabbit intra-articular adhesion model (Fukui et al 2001). However, several studies showed development of arthrogenic contracture without fibrosis in the periarticular connective tissue in spinal cord injury and immobilization models (Hagiwara et al 2010, Kaneguchi et al 2017, Kaneguchi et al 2018a, Kaneguchi et al 2018b, Kaneguchi et al 2019, Moriyama et al 2007. While it therefore remains controversial whether joint fibrosis is a major factor in arthrogenic contracture, development of fibrosis is observed in the joint capsule of remobilized joints together with progression of arthrogenic contracture (Kaneguchi et al 2017, Kaneguchi et al 2018a, Kaneguchi et al 2018b, Kaneguchi et al 2019.…”

Section: Introductionmentioning

confidence: 99%

“…However, several studies showed development of arthrogenic contracture without fibrosis in the periarticular connective tissue in spinal cord injury and immobilization models (Hagiwara et al 2010, Kaneguchi et al 2017, Kaneguchi et al 2018a, Kaneguchi et al 2018b, Kaneguchi et al 2019, Moriyama et al 2007. While it therefore remains controversial whether joint fibrosis is a major factor in arthrogenic contracture, development of fibrosis is observed in the joint capsule of remobilized joints together with progression of arthrogenic contracture (Kaneguchi et al 2017, Kaneguchi et al 2018a, Kaneguchi et al 2018b, Kaneguchi et al 2019. We previously showed that anti-inflammatory treatment using the steroidal drug dexamethasone can prevent remobilization-induced arthrogenic contracture progression by suppressing joint capsule fibrosis and fibroblast proliferation (Kaneguchi et al 2018b).…”

Section: Introductionmentioning

confidence: 99%

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Intra-Articular Injection of Mitomycin C Prevents Progression of Immobilization-Induced Arthrogenic Contracture in the Remobilized Rat Knee

2020

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This study tested whether cell cycle inhibitor mitomycin C (MMC) prevents arthrogenic contracture progression during remobilization by inhibiting fibroblast proliferation and fibrosis in the joint capsule. Rat knees were immobilized in a flexed position to generate flexion contracture. After three weeks, the fixation device was removed and rat knees were allowed to freely move for one week. Immediately after and three days after fixator removal, rats received intra-articular injections of MMC or saline. The passive extension range of motion (ROM) was measured before and after myotomy of the knee flexors to distinguish myogenic and arthrogenic contractures. In addition, both cellularity and fibrosis in the posterior joint capsule were assessed histologically. Joint immobilization significantly decreased ROMs both before and after myotomy compared with untreated controls. In saline-injected knees, remobilization increased ROM before myotomy, but further decreased that after myotomy compared with that of knees immediately after three weeks of immobilization. Histological analysis revealed that hypercellularity, mainly due to fibroblast proliferation, and fibrosis characterized by increases in collagen density and joint capsule thickness occurred after remobilization in saline-injected knees. Conversely, MMC injections were able to prevent the remobilization-enhanced reduction of ROM after myotomy by inhibiting both hypercellularity and joint capsule fibrosis. Our results suggest that joint capsule fibrosis accompanied by fibroblast proliferation is a potential cause of arthrogenic contracture progression during remobilization, and that inhibiting fibroblast proliferation may constitute an effective remedy.

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Section: Discussionmentioning

confidence: 87%

Section: Joint Immobilization and Remobilizationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Intra-Articular Injection of Mitomycin C Prevents Progression of Immobilization-Induced Arthrogenic Contracture in the Remobilized Rat Knee

2020

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Formation process of joint contracture after anterior cruciate ligament reconstruction in rats

Kaneguchi

Ozawa

Minamimoto

et al. 2020

Journal Orthopaedic Research

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Knee joint contracture is often induced by anterior cruciate ligament reconstruction (ACLR). However, the temporal and spatial arthrofibrotic changes following inflammatory events, which occur in parallel with the formation of joint contractures after ACLR, are unknown. This study aimed to reveal: (a) time-dependent changes in myogenic and arthrogenic contractures; and (b) the process of arthrofibrosis development after ACLR. ACLR was performed on knees of rats unilaterally. Passive ranges of motions (ROMs) before and after myotomy, as well as inflammatory and fibrotic reactions, were examined before and after the surgery at various periods up to 56 days. Both ROMs before and after myotomy exhibited their lowest value on day 7 and increased thereafter in a time-dependent manner; nevertheless,

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Applications of photobiomodulation in hearing research: from bench to clinic

et al. 2019

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Hearing loss is very common and economically burdensome. No accepted therapeutic modality for sensorineural hearing loss is yet available; most clinicians emphasize rehabilitation, placing hearing aids and cochlear implants. Photobiomodulation (PBM) employs light energy to enhance or modulate the activities of specific organs, and is a popular non-invasive therapy used to treat skin lesions and neurodegenerative disorders. Efforts to use PBM to improve hearing have been ongoing for several decades. Initial in vitro studies using cell lines and ex vivo culture techniques have now been supplanted by in vivo studies in animals; PBM protects the sensory epithelium and triggers neural regeneration. Many reports have used PBM to treat tinnitus. In this brief review, we introduce PBM applications in hearing research, helpful protocols, and relevant background literature.

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Low-Level Laser Therapy Prevents Treadmill Exercise-Induced Progression of Arthrogenic Joint Contracture Via Attenuation of Inflammation and Fibrosis in Remobilized Rat Knees

Cited by 22 publications

References 37 publications

Intra-Articular Injection of Mitomycin C Prevents Progression of Immobilization-Induced Arthrogenic Contracture in the Remobilized Rat Knee

Intra-Articular Injection of Mitomycin C Prevents Progression of Immobilization-Induced Arthrogenic Contracture in the Remobilized Rat Knee

Formation process of joint contracture after anterior cruciate ligament reconstruction in rats

Applications of photobiomodulation in hearing research: from bench to clinic

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