Low Levels of Serum β-Carotene and β-Carotene/Retinol Ratio Are Associated with Histological Severity in Nonalcoholic Fatty Liver Disease Patients

Wang, Lijun; Ding, Chenghe; Zeng, Fangfang; Zhu, Huilian

doi:10.1159/000496458

Cited by 17 publications

(10 citation statements)

References 24 publications

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“…According to this, the researchers indicated that both β-carotene and SC/SR decreased gradually with the progression of the disease—from the normal liver, hepatic steatosis, to the limit of steatohepatitis. These results showed that a lower concentration of circulating β-carotene and an SC/SR ratio are associated with the histological severity of NAFLD [130].…”

Section: Carotenoids and Hepatic Healthmentioning

confidence: 99%

Nutritional Importance of Carotenoids and Their Effect on Liver Health: A Review

2019

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The consumption of carotenoids has beneficial effects on health, reducing the risk of certain forms of cancer, cardiovascular diseases, and macular degeneration, among others. The mechanism of action of carotenoids has not been clearly identified; however, it has been associated with the antioxidant capacity of carotenoids, which acts against reactive oxygen species and inactivating free radicals, although it has also been shown that carotenoids modulate gene expression. Dietary carotenoids are absorbed and accumulated in the liver and other organs, where they exert their beneficial effects. In recent years, it has been described that the intake of carotenoids can significantly reduce the risk of suffering from liver diseases, such as non-alcoholic fatty liver disease (NAFLD). This disease is characterized by an imbalance in lipid metabolism producing the accumulation of fat in the hepatocyte, leading to lipoperoxidation, followed by oxidative stress and inflammation. In the first phases, the main treatment of NAFLD is to change the lifestyle, including dietary habits. In this sense, carotenoids have been shown to have a hepatoprotective effect due to their ability to reduce oxidative stress and regulate the lipid metabolism of hepatocytes by modulating certain genes. The objective of this review was to provide a description of the effects of dietary carotenoids from fruits and vegetables on liver health.

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Section: Carotenoids and Hepatic Healthmentioning

confidence: 99%

Nutritional Importance of Carotenoids and Their Effect on Liver Health: A Review

2019

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“…The incorporation of carotenoids in therapeutic diets against steatosis is of great interest since serum β-carotene levels in patients with NAFLD (with clinical signs of liver steatosis, inflammation and fibrosis) are significantly lower than in healthy subjects. Therefore, various authors have described that a higher consumption of this carotenoid in the diet from food sources is associated with a lower risk of primary liver cancer [ 7 , 8 ]. Vegetables such as spinach and tomato are a good source of dietary carotenoids, with values that can reach 10.87 and 7.82 mg/100 g of fresh weight, respectively [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Consumption of Spinach and Tomato Modifies Lipid Metabolism, Reducing Hepatic Steatosis in Rats

et al. 2020

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Non-alcoholic fatty liver disease (NAFLD) is currently a serious and growing clinical problem in developed and developing countries and is considered one of the most frequent chronic liver diseases in the world. The aim of this study was to evaluate the functionality of dietary carotenoids provided by tomato and spinach in the dietary treatment of steatosis. Twenty-two Sprague-Dawley rats with induced steatosis were grouped into three groups and fed standard diet (CD group) and two experimental diets supplemented with 12.75% (LC12.75 group) and 25.5% (HC25.5 group) of a mixture of spinach and tomato powder. Rats fed carotenoid-rich feeds showed an improvement in the plasma biomarkers of steatosis, with lower levels of glucose, total cholesterol, VLDL, TG, proteins, ALT and AST. Likewise, a decrease in oxidative stress was observed, with a significant reduction of malondialdehyde (MDA) in plasma (up to 54%), liver (up to 51.42%) and urine (up to 78.89%) (p < 0.05) and an increase in plasma antioxidant capacity (ORAC) (up to 73.41%) (p < 0.05). Furthermore, carotenoid-rich diets led to an accumulation of carotenoids in the liver and were inversely correlated with the content of total cholesterol and hepatic triglycerides, increasing the concentrations of MUFA and PUFA (up to 32.6% and 48%, respectively) (p < 0.05). The accumulation of carotenoids in the liver caused the modulation of genes involved in lipid metabolism, and we particularly observed an overexpression of ACOX1, APOA1 and NRIH2 (LXR) and the synthesis of the proteins. This study suggests that dietary carotenoids from spinach and tomato aid in the dietary management of steatosis by reversing steatosis biomarkers.

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“…Handcrafted BPO has total carotenoid content ranging from 1661 to 1,890 mg/kg (Albuquerque et al., 2005; Aquino et al., 2012; Garcia‐Quiroz et al., 2003; Silva et al., 2009). In humans, low levels of serum β‐carotene (Christensen & Thomas Lawler, 2019; Wang et al., 2019; Xiao et al., 2019) and lower intake (Christensen & Thomas Lawler, 2019) are positively correlated with the severity of the hepatic injury caused by NAFLD.…”

Section: Introductionmentioning

confidence: 99%

Buriti pulp oil did not improve high‐fat diet‐induced metabolic disorders in c57bl/6 mice

Aydos

Amaral

Jacobowski

et al. 2020

Animal Physiology Nutrition

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Metabolic syndrome (MetS) and obesity are growing in many parts of the world, becoming public health problems. It is proposed that foods with functional properties can assist in the treatment of these diseases. Crude buriti pulp oil (BPO) is a food traditionally consumed by residents in the Pantanal, Cerrado and Brazilian Amazon. It is rich in oleic acid, tocopherols and carotenoids, emerging as a potential functional food. Thus, this study aimed to evaluate the effect of the supplementation of BPO on metabolic disorders caused by a high‐fat diet. Four groups of C57BL6 mice were used, a lean group with AIN‐93M diet and control oil supplementation, an obese group with a high‐fat diet and control oil supplementation, and two obese groups with a high‐fat diet and BPO supplementation in the amounts of 50 and 100 mg/kg. BPO worsened the metabolic state caused by the high‐fat diet, worsening risk factors associated with MetS, as the abdominal circumference and retroperitoneal fat, serum levels of total cholesterol, uric acid, alanine transaminase, glucose and triglycerides, and renal fat, in addition to changes in glycaemic control and oxidative stress markers. C57BL/6 mice fed with a high‐fat diet and supplemented with BPO presented a worsening in metabolic risk factors associated with MetS.

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Low Levels of Serum β-Carotene and β-Carotene/Retinol Ratio Are Associated with Histological Severity in Nonalcoholic Fatty Liver Disease Patients

Cited by 17 publications

References 24 publications

Nutritional Importance of Carotenoids and Their Effect on Liver Health: A Review

Nutritional Importance of Carotenoids and Their Effect on Liver Health: A Review

Consumption of Spinach and Tomato Modifies Lipid Metabolism, Reducing Hepatic Steatosis in Rats

Buriti pulp oil did not improve high‐fat diet‐induced metabolic disorders in c57bl/6 mice

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