Low Levels of the Omega‐3 Index are Associated with Sudden Cardiac Arrest and Remain Stable in Survivors in the Subacute Phase

Aarsetoey, Hildegunn; Aarsetoey, Reidun; Lindner, Thomas; Staines, Harry; Harris, William S.; Nilsen, Dennis W.T.

doi:10.1007/s11745-010-3511-3

Cited by 55 publications

(40 citation statements)

References 27 publications

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“…An epidemiologic study reported that the risk of SCD was lower in individuals with long-term fi sh consumption ( 31 ). This fi nding is consistent with studies reporting that a low omega-3 index increased the risk of ventricular fi brillation during acute ischemic phase of a MI and SCD ( 32,33 ).…”

Section: Downloaded Fromsupporting

confidence: 72%

Omega-3 fatty acid supplementation and cardiovascular disease

Jump

Depner

Tripathy

2012

Journal of Lipid Research

197

118

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Section: Downloaded Fromsupporting

confidence: 72%

Omega-3 fatty acid supplementation and cardiovascular disease

Jump

Depner

Tripathy

2012

Journal of Lipid Research

197

118

View full text Add to dashboard Cite

“…From these values we derived the omega-3 index (RBC EPA and DHA expressed as weight percentage of total fatty acids). 21 In our study population, on average DHA consisted of 87.4% of the sum DHAϩEPA. The interassay coefficient of variation was 4.9% for both EPA and DHA.…”

mentioning

confidence: 77%

Red blood cell omega-3 fatty acid levels and markers of accelerated brain aging

et al. 2012

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Objective: Higher dietary intake and circulating levels of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) have been related to a reduced risk for dementia, but the pathways underlying this association remain unclear. We examined the cross-sectional relation of red blood cell (RBC) fatty acid levels to subclinical imaging and cognitive markers of dementia risk in a middleaged to elderly community-based cohort. Methods:We related RBC DHA and EPA levels in dementia-free Framingham Study participants (n ϭ 1,575; 854 women, age 67 Ϯ 9 years) to performance on cognitive tests and to volumetric brain MRI, with serial adjustments for age, sex, and education (model A, primary model), additionally for APOE ⑀4 and plasma homocysteine (model B), and also for physical activity and body mass index (model C), or for traditional vascular risk factors (model D). Results:Participants with RBC DHA levels in the lowest quartile (Q1) when compared to others (Q2-4) had lower total brain and greater white matter hyperintensity volumes (for model A: ␤ Ϯ SE ϭ Ϫ0.49 Ϯ 0.19; p ϭ 0.009, and 0.12 Ϯ 0.06; p ϭ 0.049, respectively) with persistence of the association with total brain volume in multivariable analyses. Participants with lower DHA and -3 index (RBC DHAϩEPA) levels (Q1 vs Q2-4) also had lower scores on tests of visual memory (␤ Ϯ SE ϭ Ϫ0.47 Ϯ 0.18; p ϭ 0.008), executive function (␤ Ϯ SE ϭ Ϫ0.07 Ϯ 0.03; p ϭ 0.004), and abstract thinking (␤ Ϯ SE ϭ Ϫ0.52 Ϯ 0.18; p ϭ 0.004) in model A, the results remaining significant in all models. Conclusion:Lower RBC DHA levels are associated with smaller brain volumes and a "vascular" pattern of cognitive impairment even in persons free of clinical dementia. Neurology ® 2012;78:658-664 GLOSSARY AD ϭ Alzheimer disease; BMI ϭ body mass index; DHA ϭ docosahexaenoic acid; DM ϭ diabetes mellitus; EPA ϭ eicosapentaenoic acid; LM-d ϭ delayed recall components of the Logical Memory test; NP ϭ neuropsychological; PAI ϭ physical activity index; PUFA ϭ polyunsaturated fatty acid; RBC ϭ red blood cell; SBP ϭ systolic blood pressure; SCI ϭ silent cerebral infarct; SIM ϭ Similarities test; TCBV ϭ total cerebral brain volume; THV ϭ temporal horn volume; VR-d ϭ delayed recall component of the Visual Reproductions test; WMHV ϭ white matter hyperintensity volume.Higher fish intake has been associated with a reduced risk of cardiovascular mortality 1,2 and stroke.3 While several large epidemiologic studies 4,5 have shown an association between the estimated intake of fatty fish and a lower risk for dementia, some other investigations have failed to confirm such a protective association. 6 One possible reason for these inconsistent results is the limited ability of dietary recall surveys and food frequency questionnaires to quantify blood levels of fatty acids. 7,8 In the Framingham original cohort, participants in the top quartile of plasma phosphatidylcholine docosahexaenoic acid (DHA) levels had 37% and 47% lower risks of Alzheimer disease (AD) and all-cause dementia, respectively.9 Red blood ...

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“…Since the Omega-3-Index is inversely [35], and AA/EPA ratio directly associated with CVD risk [36], the results indicate additional aronia-juice cardio-protective effects.…”

Section: Discussionmentioning

confidence: 86%

Effects of Aronia melanocarpa juice on plasma and liver phospholipid fatty acid composition in Wistar rats

et al. 2017

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A nutritional placebo-controlled study was performed in Wistar rats in order to investigate the effects of 5-weeks aronia juice consumption towards fatty acid (FA) composition of phospholipids in the plasma and liver, as well as plasma glucose (Glu) and cholesterol levels. The animals were divided into 3 groups of 8 animals each, and randomized to receive either the full polyphenol dose of Aronia melanocarpa juice (AMJ), 4 times less polyphenol dose (¼-AMJ) or polyphenol-lacking placebo beverage (PLB). Each group of 8 male adult Wistar rats received the liquid ad libitum. AMJ decreased the levels of low-density lipoprotein (LDL) (P < 0.05) vs. PLB. AMJ increased dihomo-γ-linoleic acid (DGLA, 20:3n-6) (P < 0.05) and decreased arachidonic acid content (AA, 20:4n-6) (P < 0.05) vs. PLB in liver phospholipids. AMJ signifi cantly increased monounsaturated fatty acids (MUFA) levels both in the liver (P < 0.05) and plasma (P < 0.05). Both aronia juice doses elevated the levels of benefi cial n-3 polyunsaturated fatty acids (PUFA) in the plasma and liver. There was a dose-dependent, signifi cant increase (P < 0.001) in cis-vaccenic acid (VA, in phospholipids in the plasma and liver. Our results indicate favorable effects of aronia juice intake on lipid parameters in Wistar rats. These fi ndings suggest the potential of aronia dietary intake in cardiometabolic diseases primary prevention strategies in the human population.

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Low Levels of the Omega‐3 Index are Associated with Sudden Cardiac Arrest and Remain Stable in Survivors in the Subacute Phase

Cited by 55 publications

References 27 publications

Omega-3 fatty acid supplementation and cardiovascular disease

Omega-3 fatty acid supplementation and cardiovascular disease

Red blood cell omega-3 fatty acid levels and markers of accelerated brain aging

Effects of Aronia melanocarpa juice on plasma and liver phospholipid fatty acid composition in Wistar rats

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