Low levels of vitamin D and worsening of knee osteoarthritis: Results of two longitudinal studies

Felson, David T.; Niu, Jingbo; Clancy, Margaret; Aliabadi, Piran; Sack, Burton; Guermazi, Ali; Hunter, David J.; Amin, Shreyasee; Rogers, Gail; Booth, Sarah L.

doi:10.1002/art.22292

Cited by 167 publications

(132 citation statements)

References 21 publications

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“…In participants of the "Framingham Study", low serum 25-OHD predicted the development of cartilage loss and knee OA progression [14]. However, the association of vitamin D deficiency and OA was not confirmed by another longitudinal study by Felson et al [16].…”

Section: Discussionmentioning

confidence: 95%

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Association between serum vitamin D deficiency and knee osteoarthritis

Heidari

Hajian‐Tilaki

2010

International Orthopaedics (SICOT)

108

100

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Background Insufficient levels of serum 25-hydroxyvitamin D (25-OHD) influence the knee joint cartilage and lead to development and progression of knee osteoarthritis (OA). The purpose of this study was to determine the status of serum 25-OHD levels in patients with knee OA compared with controls. Methods A total of 148 patients with knee OA and 150 controls were studied. Serum 25-OHD was measured by the ELISA method and concentrations<20 ng/ml were considered as deficient levels. Mann-Whitney U test was used for comparisons of means and logistic regression analysis with calculation of odds ratio (OR) was applied to determine association. Results The mean ages of patients and controls were 60.2± 12.9 and 60.1±10.2 years, respectively (P=0.23). In the entire population the mean serum 25-OHD in OA patients was not significantly lower than controls (P=0.28), but in subgroup analysis the mean 25-OHD in OA patients aged <60 years was significantly lower than controls (23.8±18.8 vs. 34.5.±29.6 ng/ml, P=0.01). In this age group knee OA was significantly associated with serum 25-OHD deficiency which remained significant after adjusting for age and sex (adjusted OR=2.26, 95% CI 1.15-4.4, P=0.018). A greater association was observed in patients aged<55 years (OR=2.63, 95% CI 1.16-5.95, P= 0.01); whereas the association between OA and serum 25-OHD deficiency in patients aged ≥60 years did not reach a significant level. Conclusion These findings indicate a significant association between serum 25-OHD deficiency and knee OA in patients aged < 60 years and suggest serum 25-OHD measurement in any patient with symptoms suggestive of knee OA particularly at the initial stage of disease.

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Section: Discussionmentioning

confidence: 95%

“…Up to now most studies addressed the association between OA and serum 25-OHD in longitudinal studies [5,6,[14][15][16][17]. No study has yet compared serum 25-OHD levels between OA patients and controls.…”

Section: Discussionmentioning

confidence: 99%

Association between serum vitamin D deficiency and knee osteoarthritis

Heidari

Hajian‐Tilaki

2010

International Orthopaedics (SICOT)

108

100

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“…However more recent results from two longitudinal cohort studies, the Framingham Offspring cohort (715 subjects) and the Boston Osteoarthritis of the Knee Study (BOKS) (277 subjects) [125] found no association of baseline 25(OH)D concentration with radiographic worsening of joint space narrowing nor any relationship with cartilage loss.…”

Section: Vitamin D In Ramentioning

confidence: 95%

Dietary manipulation in musculoskeletal conditions

Rayman

Pattison

2008

Best Practice & Research Clinical Rheumatology

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“…Although vitamin D was also shown to be an important hormonal contributor to cartilage and chondrocyte homeostasis and vitamin D receptors are present in chondrocytes [152], its role in OA is far less understood and still controversial. Indeed, while some clinical studies reported that vitamin D deficiency was associated with an increased risk of progression of knee OA and incidence of hip OA [153,154], others demonstrated no association between serum vitamin D levels and joint space loss or worsening cartilage score in knee OA [155,156]. Most of these studies used radiographic assessment of OA and one also employed MRI.…”

Section: Drugs/agents That Target Bone Remodellingmentioning

confidence: 99%

“…Most of these studies used radiographic assessment of OA and one also employed MRI. However, in the study using MRI [155], the authors did not assess the whole knee or cartilage volume. Interestingly, in a recent study [157] in which the assessment of knee OA structural changes was performed both radiographically and by quantitative MRI, a change in serum vitamin D level was positively associated with change in cartilage volume.…”

Section: Drugs/agents That Target Bone Remodellingmentioning

confidence: 99%

Targeting subchondral bone for treating osteoarthritis: what is the evidence?

Tat

Lajeunesse

Pelletier

et al. 2010

Best Practice & Research Clinical Rheumatology

156

121

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Over the past few decades, significant progress has been made with respect to new concepts about the pathogenesis of osteoarthritis (OA). This article summarises some of the knowledge we have today on the involvement of the subchondral bone in OA. It provides substantial evidence that changes in the metabolism of the subchondral bone are an integral part of the OA disease process and that these alterations are not merely secondary manifestations, but are part of a more active component of the disease. Thus, a strong rationale exists for therapeutic approaches that target subchondral bone resorption and/or formation, and data evaluating the drugs targeting bone remodelling raise the hope that new treatment options for OA may become available.

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Low levels of vitamin D and worsening of knee osteoarthritis: Results of two longitudinal studies

Cited by 167 publications

References 21 publications

Association between serum vitamin D deficiency and knee osteoarthritis

Association between serum vitamin D deficiency and knee osteoarthritis

Dietary manipulation in musculoskeletal conditions

Targeting subchondral bone for treating osteoarthritis: what is the evidence?

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