Low Micronutrient Levels as a Predictor of Incident Disability in Older Women

Bartali, Benedetta; Semba, Richard D.; Frongillo, Edward A.; Varadhan, Ravi; Ricks, Michelle O.; Blaum, Caroline S.; Ferrucci, Luigi; Guralnik, Jack M.; Fried, Linda P.

doi:10.1001/archinte.166.21.2335

Cited by 68 publications

(54 citation statements)

References 24 publications

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“…Concerning dietary micronutrient intake, women of the E3N study with IADL impairment reported past lower intakes of vitamins B6 and B12 [15]. Biological data confirm these findings since low serum concentration of vitamins B6 and B12, were significant and independent predictors of ADL disability 3 years later in women enrolled in the Women"s Health and Aging Study while carotenoids, zinc and folate levels, which are also yet common in the MeDi, were not significant predictors [10].…”

Section: Discussionmentioning

confidence: 72%

Adherence to a Mediterranean diet and onset of disability in older persons

et al. 2011

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Section: Discussionmentioning

confidence: 72%

Adherence to a Mediterranean diet and onset of disability in older persons

et al. 2011

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“…Many reports have demonstrated that frailty is more common in women, (Bartali et al, 2006;Cappola et al, 2009;Fernández-Garrido et al, 2014b;Kamel, 2003) indeed specific pre-operative frailty assessments are well-accepted by gynecological cancer patients, and are a feasible tool in a clinical setting (CourtneyBrooks et al, 2012). Dale et al (2014) demonstrated that previous knowledge about the exhaustion or physical performance deficits in patients with pancreatic tumour considered suitable for pancreaticoduodenectomy can help to predict clinically relevant outcomes.…”

Section: Discussionmentioning

confidence: 99%

Frailty syndrome and pre-operative risk evaluation: A systematic review

Buigues

Juarros-Folgado

Fernández-Garrido

et al. 2015

Archives of Gerontology and Geriatrics

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“…This is directly associated with the loss of physical reserves seen in frailty, and is independently associated with increased risk of mortality, morbidity, complications, and functional decline [30,33,90]. In addition to promoting decline of body stores of protein, frailty has been associated with declining micronutrient levels, such as iron, B vitamins, folate [91,92].…”

Section: Treatment Strategiesmentioning

confidence: 99%

Musculoskeletal health, frailty and functional decline

Milte

Crotty

2014

Best Practice & Research Clinical Rheumatology

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Frailty in older people is associated with a vulnerability to adverse events. While ageing is associated with a loss of physiological reserves identifying those with the syndrome of frailty has the potential to assist clinicians tailor treatments to those at risk of future decline into disability with increased risk of complications, morbidity and mortality. Sarcopenia is a key component of the frailty syndrome and on its own puts older people at risk of fragility fractures however the clinical syndrome of frailty affects musculoskeletal and non musculoskeletal systems. Hip fractures are becoming a prototype condition in the study of frailty. Following a hip fracture many of the interventions are focused on limiting mobility disability and restoring independence with activities of daily living but there are multiple factors to be addressed including osteoporosis, sarcopenia, delirium, weight loss. Established techniques of geriatric evaluation and management allow systematic assessment and intervention on multiple components by multidisciplinary teams and deliver the best outcomes. Using the concept of frailty to identify older people with musculoskeletal problems as at risk of a poor outcome assists in treatment planning and is likely to become more important as effective pharmacological treatments for sarcopenia emerge. This review will focus on the concept of frailty and its relationship with functional decline, as well as describing its causes, prevalence, risk factors and potential clinical applications and treatment strategies. Key wordsFragility fracture, frailty, functional decline, screening, older adult, exercise therapy, dietary therapy Word count 9,401 words (word limit=9,400)

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Low Micronutrient Levels as a Predictor of Incident Disability in Older Women

Cited by 68 publications

References 24 publications

Adherence to a Mediterranean diet and onset of disability in older persons

Adherence to a Mediterranean diet and onset of disability in older persons

Frailty syndrome and pre-operative risk evaluation: A systematic review

Musculoskeletal health, frailty and functional decline

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