Low-molecular procyanidin rich grape seed extract exerts antihypertensive effect in males spontaneously hypertensive rats

Quiñones, Mar; Guerrero, Ligia; Suárez, Manuel; Pons, Zara; Aleixandre, Amaya; Arola, Lluı́s; Muguerza, Begoña

doi:10.1016/j.foodres.2013.01.023

Cited by 90 publications

(87 citation statements)

References 89 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In fact, both assayed extracts have different antioxidant capacities (Table 1, supporting information), which could be explained by their different composition. CE has a high content in epicatechin‐derived proantocyanidins and flavone glucuronide sulfates as the main monomeric flavonoid, while GSPE has a high content of proanthocyanidins and flavanols, and galloyl forms, as main monomeric flavonoids . Not only different antioxidant capacities have been shown for different flavonoid structures, but also the combination of compounds affects the antioxidant capacity of a mixture …”

Section: Resultsmentioning

confidence: 99%

Antioxidant effects of proanthocyanidin‐rich natural extracts from grape seed and cupuassu on gastrointestinal mucosa

et al. 2015

View full text Add to dashboard Cite

show abstract

Section: Resultsmentioning

confidence: 99%

Antioxidant effects of proanthocyanidin‐rich natural extracts from grape seed and cupuassu on gastrointestinal mucosa

et al. 2015

View full text Add to dashboard Cite

show abstract

“…In this study, Taisho-Kintoki (red kidney) bean had the highest procyanidin content of all 28 common beans tested (5.7 mg CE / g seed). Nevertheless, it is still lower than that in chokeberry and grape [19,20]. Data are means ± SD from at least three independent studies.…”

Section: Total Polyphenol and Antioxidant Activities In Common Beansmentioning

confidence: 90%

Characteristics of Functional Components and Antioxidant Activity of 28 Common Beans

Jiang¹,

Ci²,

Feng³

et al. 2018

JFNR

View full text Add to dashboard Cite

Common beans are either white or colored. They contain large amounts of phenolic compounds and other phytochemicals. Polyphenols exhibit high antioxidant activity that promote health by reducing oxidative stress. The objective of this study was to compare the content and composition of polyphenols in 28 common beans and determine the relation between their antioxidant activities and seed coat color. Here, we measured seed coat color by the International Commission in Illumination method, estimated polyphenol content and antioxidant activity by colorimetry, and identified polyphenol compositions by RP-HPLC. The results showed that polyphenol content and antioxidant activity were higher in colored beans than in the white beans. Taisho-Kintoki (red kidney) had the highest polyphenol content (6.12 mg / g seed) and antioxidant activity (21.98 μmol / g seed; 3.75 mg / g seed). There was a high correlation between the total polyphenol content and seed coat redness. There were also high equilateral correlations between antioxidant activity and polyphenol content. Twelve phenolic compounds were identified. Based on their polyphenol compositions synthesized by various enzymes, the 28 common beans were divided into three groups. White beans and several half-spotted beans contained a large amount of catechin-7-O-glucoside with low antioxidant activity. Anthocyanin, procyanidin, and kaempferol-3-O-glucoside constituted significant proportions of the total polyphenol compounds and were positively correlated with antioxidant activity in the colored common beans. These findings are expected to help guide consumers and breeders in the selection of common bean varieties with high antioxidant activity.

show abstract

“…According to the manufacturer, the extract contains monomeric (21.3%), dimeric (17.4%), trimeric (16.3%), tetrameric (13.3%) and oligomeric (5–13 units; 31.7%) proanthocyanidins. GSPE were characterized in more detail by reverse-phase chromatographic analyses by our research group [23]. Briefly, the main compounds (up to tetramers) found in the GSPE lot used in this study were gallic acid (31 mg/g), (epi)catechin (214 mg/g), epicatechin gallate (21 mg/g), procyanidin dimers (168 mg/g), procyanidin dimer gallate (9 mg/g) and trimers (5 mg/g).…”

Section: Methodsmentioning

confidence: 99%

Defining Conditions for Optimal Inhibition of Food Intake in Rats by a Grape-Seed Derived Proanthocyanidin Extract

et al. 2016

View full text Add to dashboard Cite

Food intake depends on homeostatic and non-homeostatic factors. In order to use grape seed proanthocyanidins (GSPE) as food intake limiting agents, it is important to define the key characteristics of their bioactivity within this complex function. We treated rats with acute and chronic treatments of GSPE at different doses to identify the importance of eating patterns and GSPE dose and the mechanistic aspects of GSPE. GSPE-induced food intake inhibition must be reproduced under non-stressful conditions and with a stable and synchronized feeding pattern. A minimum dose of around 350 mg GSPE/kg body weight (BW) is needed. GSPE components act by activating the Glucagon-like peptide-1 (GLP-1) receptor because their effect is blocked by Exendin 9-39. GSPE in turn acts on the hypothalamic center of food intake control probably because of increased GLP-1 production in the intestine. To conclude, GSPE inhibits food intake through GLP-1 signaling, but it needs to be dosed under optimal conditions to exert this effect.

show abstract

Low-molecular procyanidin rich grape seed extract exerts antihypertensive effect in males spontaneously hypertensive rats

Cited by 90 publications

References 89 publications

Antioxidant effects of proanthocyanidin‐rich natural extracts from grape seed and cupuassu on gastrointestinal mucosa

Antioxidant effects of proanthocyanidin‐rich natural extracts from grape seed and cupuassu on gastrointestinal mucosa

Characteristics of Functional Components and Antioxidant Activity of 28 Common Beans

Defining Conditions for Optimal Inhibition of Food Intake in Rats by a Grape-Seed Derived Proanthocyanidin Extract

Contact Info

Product

Resources

About