Low Molecular Weight Di‐ to Tetrapeptide Transmembrane Cation Transporters

Abstract

Low molecular weight di‐, tri‐ and tetrapeptide transmembrane ion transporters containing aminobenzoic acid and l/d alanine are reported. These short peptides transport alkali metal cations in preference to halides across the lipid bilayer most likely through a carrier mechanism. Easy access to these peptides and the ability to install diverse functional groups into the peptidic scaffold make them attractive scaffolds for therapeutic use.

Charge variable PIB-based block copolymers as selective transmembrane ion transporters

“…14,15 Selective ion transport has been accelerated with the help of various interactions and binding forces, such as electrostatic forces, hydrogen bonding, ligand binding, ion-dipole interactions, etc. 16 Several artificial ionophores based on peptides, 17,18 macrocyclic materials, 19,20 amphiphilic synthetic scaffolds, 21 etc., have already been reported. Ionophoric activity using polymeric materials is an emerging topic in recent times.…”