Low numbers of functionally active B lymphocytes in the peripheral blood of HIV-1-seropositive individuals with low p24-specific serum antibody titers

Teeuwsen, Vera; Lange, Jessica; Keet, R.; Schattenkerk, J. K. M. E.; Debouck, Christine; Akker, R. van den; Goudsmit, Jaap; Osterhaus, Albert D. M. E.

doi:10.1097/00002030-199108000-00008

Cited by 23 publications

(15 citation statements)

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“…The few intervening publications have documented a decrease in the CD19 + /CD5 + B-cell compartment in 7-to 12-month-old HIV-1 + infants, 35 lower CD19 + B-cell numbers in more symptomatic HIV-1 + children, 36 low numbers of functionally active B cells in HIV-1 + patients with low p24 antibody serum titers, 37 and high serum IgG and IgA levels in HIV-1 + children. 38 Recently, Rubinstein et al 39 have documented progressive immunologic attrition in 17 relatively asymptomatic HIV + adults by using bacteriophage ϕ X174 immunizations.…”

Section: Discussionmentioning

confidence: 99%

Prospective 5-year study of peripheral blood CD4+, CD8+, and CD19+/CD20+ lymphocytes and serum Igs in children born to HIV-1+ women

Shearer¹,

Easley²,

Goldfarb³

et al. 2000

Journal of Allergy and Clinical Immunology

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Section: Discussionmentioning

confidence: 99%

Prospective 5-year study of peripheral blood CD4+, CD8+, and CD19+/CD20+ lymphocytes and serum Igs in children born to HIV-1+ women

Shearer¹,

Easley²,

Goldfarb³

et al. 2000

Journal of Allergy and Clinical Immunology

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“…This may have important implications for the development of a successful HIV-1 vaccine for infants, if the time course of production of antibodies to gpl20 and gp4l is limited by developmentally regulated immune maturation. The relatively low proportion of infants with measurable IVAP to p24 is not appreciably different than that seen in adults (22) and may be related to the restricted clonal frequency of cells producing antibody to this antigen (23). Furthermore, complexing of antibody with p24 antigen simultaneously secreted into the culture supernatant may contribute to the poor apparent humoral response to this antigen (22).…”

Section: Discussionmentioning

confidence: 99%

“…The relatively low proportion of infants with measurable IVAP to p24 is not appreciably different than that seen in adults (22) and may be related to the restricted clonal frequency of cells producing antibody to this antigen (23). Furthermore, complexing of antibody with p24 antigen simultaneously secreted into the culture supernatant may contribute to the poor apparent humoral response to this antigen (22). The ability of many infected infants to produce HIV-specific IgG at birth confirms that fetal B cells, which are normally "naive," are capable of responding to certain antigens or antigen-like moieties.…”

Section: Discussionmentioning

confidence: 99%

Ontogeny of anti-human immunodeficiency virus (HIV) antibody production in HIV-1-infected infants.

Pollack

Zhan

Ilmet-Moore

et al. 1993

Proc. Natl. Acad. Sci. U.S.A.

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The early serologic response of infants to infection with human immunodeficiency virus type 1 (HIV-1) is normally obscured by the presence of transplacentally acquired maternal HIV antibody. By measuring HIV antibody produced in vitro by lymphocytes isolated from peripheral blood of infants and children of HIV-1-infected mothers, we have been able to study the natural acquisition of humoral immunity to perinatal HIV-1 infection. One hundred ninety-seven infants of HIV-1-infected women were studied prospectively and longitudinally from birth. In the neonatal period, infected infants produced only small amounts of HIV-specific IgG antibodies to a restricted number of antigens. The amount of immunoglobulin to HIV-1 and the number of HIV-1 antigens recognized increased with age. After 6 months of life 85% of infected infants made detectable antibody to two or more viral proteins. Antibody to gp160 appeared first and was the most frequently found at all ages, followed by antibody to the envelope proteins gp120 and gp41. The amount of HIV antibody produced correlated positively with the percentage of CD4+ T lymphocytes in peripheral blood. This assay provides a method of studying the immunogenicity of vaccines against HIV-1 in HIV-1-infected infants and of assessing the effect of early therapeutic interventions on the humoral response to HIV-1.

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“…There were two explanations for the low levels of anti-p24 antibody in the rapid progressors: high viral load, which results in the formation of immune complexes; and low antibody production due to the decrease or dysfunction of active B lymphocytes. 34 Among the 12 groups shown in Fig. 3A, the group of patients with the highest VL levels and lowest T4 counts (group 4±C) was found to have the lowest rate of occurrence of anti-Gag antibody.…”

Section: Anti-nef Antibody As Disease Progression Marker 47mentioning

confidence: 86%

Decreasing Levels of Anti-Nef Antibody Correlate with Increasing HIV Type 1 Viral Loads and AIDS Disease Progression

Chen¹,

Lin

Lee

et al. 1999

AIDS Research and Human Retroviruses

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To study the association between anti-Gag and anti-Nef antibody reactivities and their correlations with disease progression, 174 HIV-1/AIDS patients were followed up for 1 year after they received triple therapy. The antibody reactivities were analyzed using a Western blot test with recombinant Gag and Nef proteins. The results showed that decreasing levels of anti-Gag or anti-Nef antibody correlate with disease progression defined by HIV-1 viral loads or T4 cell counts. After receiving triple treatment for 1 year, 8 of 38 (21.1%) Nef antibody-negative patients became positive, while only 9 of 125 (7.2%) Nef antibody-positive persons lost the antibody reactivity (p < 0.01). Therefore, HIV-1 Nef may serve as a clinical marker of disease progression.

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Low numbers of functionally active B lymphocytes in the peripheral blood of HIV-1-seropositive individuals with low p24-specific serum antibody titers

Cited by 23 publications

References 0 publications

Prospective 5-year study of peripheral blood CD4+, CD8+, and CD19+/CD20+ lymphocytes and serum Igs in children born to HIV-1+ women

Prospective 5-year study of peripheral blood CD4+, CD8+, and CD19+/CD20+ lymphocytes and serum Igs in children born to HIV-1+ women

Ontogeny of anti-human immunodeficiency virus (HIV) antibody production in HIV-1-infected infants.

Decreasing Levels of Anti-Nef Antibody Correlate with Increasing HIV Type 1 Viral Loads and AIDS Disease Progression

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