A new continuum-based liquid sloshing approach that accounts for the effect of complex fluid and tank-car geometry on railroad vehicle dynamics is developed in this investigation. A unified geometry/analysis mesh is used from the outset to examine the effect of liquid sloshing on railroad vehicle dynamics during curve negotiation and during the application of electronically controlled pneumatic (ECP) brakes that produce braking forces uniformly and simultaneously across all cars. Using a non-modal approach, the geometry of the tank-car and fluid is accurately defined, a continuum-based fluid constitutive model is employed, and a fluid-tank contact algorithm is developed. The liquid sloshing model is integrated with a three-dimensional multibody system (MBS) railroad vehicle algorithm which accounts for the nonlinear wheel/rail contact. The three-dimensional wheel/rail contact force formulation used in this study accounts for the longitudinal, lateral, and spin creep forces that influence the vehicle stability. In order to examine the effect of the liquid sloshing on the railroad vehicle dynamics during curve negotiation, a general and precise definition of the outward inertia force is defined, and in order to correctly capture the fluid and tank-car geometry, the absolute nodal coordinate formulation (ANCF) is used. The balance speed and centrifugal effects in the case of tank-car partially filled with liquid are studied and compared with the equivalent rigid body model in curve negotiation and braking scenarios. In particular, the results obtained in the case of the ECP brake application of two freight car model are compared with the results obtained when using conventional braking. The traction analysis shows that liquid sloshing has a significant effect on the load distribution between the front and rear trucks. A larger coupler force develops when using conventional braking compared with ECP braking, and the liquid sloshing contributes to amplifying the coupler force in the ECP braking case compared to the equivalent rigid body model which does not capture the fluid nonlinear inertia effects. Furthermore, the results obtained in this study show that liquid sloshing can exacerbate the unbalance effects when the rail vehicle negotiates a curve at a velocity higher than the balance speed.