Low Plasma 25-Hydroxyvitamin D and Risk of Tobacco-Related Cancer

Afzal, Shoaib; Bojesen, Stig E.; Nordestgaard, Børge G.

doi:10.1373/clinchem.2012.201939

Cited by 98 publications

(125 citation statements)

References 35 publications

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“…147 abstracts were excluded because they were irrelevant to the current meta-analysis, and 9 studies were left and were assessed by reading full-text [13,14,15,16,22,23,24,25,26]. One study was excluded for lack of usable data [22], and one was excluded for containing overlapping data [26].…”

Section: Resultsmentioning

confidence: 99%

“…One study was excluded for lack of usable data [22], and one was excluded for containing overlapping data [26]. Thus, seven studies met the inclusion criteria and were finally included into the meta-analysis [13,14,15,16,23,24,25]. Those 7 studies contained with a total of 62,141 participants, and were published from 2006 to 2013 [13,14,15,16,23,24,25].…”

Section: Resultsmentioning

confidence: 99%

“…Previous studies also have suggested that vitamin D can inhibit proliferation and induce apoptosis in human bladder tumor cells in vitro , and may have therapeutic potential in bladder cancer [11,12]. Several epidemiological studies were published to assess the relationship between vitamin D status and bladder carcinoma risk, but failed to find consistent results [9,13,14,15,16]. Thus, vitamin D status in relation to bladder carcinoma risk was still unclear.…”

Section: Introductionmentioning

confidence: 99%

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Vitamin D Deficiency and Increased Risk of Bladder Carcinoma: A Meta-Analysis

Zhang

Wen

et al. 2015

Cell Physiol Biochem

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Background/Aims: Vitamin D status in relation to bladder carcinoma risk was still inconsistent. This study was carried out to evaluate the relationship between vitamin D status and bladder carcinoma risk through a meta-analysis approach. Methods: Pubmed, Web of Science, CNKI, and Embase were searched systemically to find eligible studies from the earliest available date to April 16, 2015. The search terms “vitamin D”, “25-hydroxyvitamin D”, “bladder cancer” or “bladder carcinoma” were used to retrieve relevant studies. The exposure of interest was intake of vitamin D or serum vitamin D levels, and the outcome of interest was bladder carcinoma incidence or mortality. The pooled risk ratio (RR) values and their 95%CIs were calculated through meta-analysis. Results: Seven studies with a total of 62,141 participants met the inclusion criteria and were finally included into the meta-analysis. There was no heterogeneity among those included studies (I² = 0%, P = 0.53). The pooled RR of bladder carcinoma for the lowest category versus the highest category of vitamin D was 1.34 (95% CI 1.17-1.53, P < 0.0001). Sensitivity analysis by omitting one study by turns showed all the pooled RRs were statistically significant. Meta-analysis of 5 studies reporting outcomes of serum vitamin D levels also showed that the low serum vitamin D level was associated with increased risk of bladder carcinoma (RR = 1.32, 95%CI 1.15-1.52, P = 0.0001). No obvious risk of publication bias was observed. Conclusion: Vitamin D deficiency is associated with increased risk of bladder carcinoma in present study.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Vitamin D Deficiency and Increased Risk of Bladder Carcinoma: A Meta-Analysis

Zhang

Wen

et al. 2015

Cell Physiol Biochem

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“…In an observational study of tobacco‐related tumours, participants with 50% lower circulating 25OHD were more likely to develop HNC after accounting for available potential confounders (Hazard ratio = 1.44 [95% confidence interval (CI): 1.19, 1.73]) 10. A recent prospective European cohort study also found strong evidence for an inverse association between circulating 25OHD on HNC risk (odds ratio [OR] per doubling of circulating 25OHD concentration = 0.69 [95% CI: 0.56, 0.87], p = 9×10 −4 ) 11.…”

Section: Introductionmentioning

confidence: 99%

Assessing the causal association between 25‐hydroxyvitamin D and the risk of oral and oropharyngeal cancer using Mendelian randomization

Dudding

Johansson

Thomas

et al. 2018

Intl Journal of Cancer

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Circulating 25‐hydroxyvitamin D (25OHD) is an appealing potential intervention for cancer risk and has been associated with oral and oropharyngeal cancer risk but evidence is inconsistent. The availability of genetic variants, uncorrelated with known confounders, but predictive of 25OHD and genetic data in a large oral and oropharyngeal cancer collaboration aids causal inference when assessing this association. A total of 5,133 oral and oropharyngeal cancer cases and 5,984 controls with genetic data were included in the study. Participants were based in Europe, North America and South America and were part of the Genetic Associations and Mechanisms in Oncology (GAME‐ON) Network. Five genetic variants reliably associated with circulating 25OHD were used to create a relative genetic measure of 25OHD. In the absence of measured 25OHD, two‐sample Mendelian randomization using individual level outcome data were used to estimate causal odds ratios (OR) for cancer case status per standard deviation increase in log25OHD. Analyses were replicated in an independent population‐based cohort (UK Biobank). In the GAME‐ON study, there was little evidence of a causal association between circulating 25OHD and oral cancer (OR = 0.86 [0.68;1.09], p = 0.22), oropharyngeal cancer (OR = 1.28 [0.72;2.26], p = 0.40) or when sites were combined (OR = 1.01 [0.74;1.40], p = 0.93). Replication in UK Biobank and pooled estimates produced similar results. Our study suggests that a clinically relevant protective effect of 25OHD on oral and oropharyngeal cancer risk is unlikely and supplementation of the general population with 25OHD is unlikely to be beneficial in preventing these cancers.

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“…The article by Afzal et al in this issue of Clinical Chemistry (1 ) presents data showing an association of low concentrations of vitamin D with risk of tobacco-related cancers. The authors found that vitamin D was not associated with other types of cancer, that the effect was stronger among smokers, and that it appeared to be independent of levels of tobacco consumption among smokers.…”

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confidence: 99%