Low plasma vitamin D levels in patients with familial Mediterranean fever

Erten, Şükran; Altunoğlu, Alpaslan; Ceylan, Gülay Güleç; Maraş, Yüksel; Koca, Cemile; Yüksel, Aydan

doi:10.1007/s00296-011-2281-4

Cited by 20 publications

(33 citation statements)

References 13 publications

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“…However, they did not include any acute phase reactants; such as C-reactive protein (CRP), erythrocyte sedimentation rate or serum amyloid A in their study. Although we could not show a significant correlation between CRP and vitamin D levels in our previous study, Erten et al 6 found a significant negative correlation between low serum vitamin D levels and acute-phase reactants. They suggested that decreased vitamin D levels in patients with FMF could be another indirect sign, but not the reason, of ongoing inflammation.…”

Section: Colchicine Resistance and Low Vitamin D In Familial Mediterrcontrasting

confidence: 93%

Colchicine resistance and low vitamin D in familial Mediterranean fever

et al. 2015

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Section: Colchicine Resistance and Low Vitamin D In Familial Mediterrcontrasting

confidence: 93%

Colchicine resistance and low vitamin D in familial Mediterranean fever

et al. 2015

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“…In a study from Turkey, the authors found low vit D levels in AS patients compared with those observed in controls without detecting a significant association with acute phase reactants and concluded that vit D deficiency in patients with AS may indirectly lead to osteoporosis by causing increases in inflammatory activity (11). Recently, we also found decreased vit D levels in patients with familial Mediterranean fever that were inversely related to the ESR, CRP and fibrinogen levels (17).…”

Section: Discussionmentioning

confidence: 76%

Decreased Plasma Vitamin D Levels in Patients with Undifferentiated Spondyloarthritis and Ankylosing Spondylitis

Erten¹,

Küçükşahin

Şahin

et al. 2013

Intern. Med.

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Objective The aim of the present study was to evaluate the plasma vitamin D (vit D) levels and their association with the disease activity in patients with ankylosing spondylitis (AS) and undifferentiated spondyloarthritis (uSpA) compared with healthy populations. Methods This study included 161 spondyloarthritis patients (113 uSpA patients and 48 AS patients) attending our rheumatology out-patient clinic, along with 92 controls. Results The plasma vit D levels were 18 μg/L (8-38) in the AS group, 20 μg/L (4-92.3) in the uSpA group and 24.3 μg/L (7.2-76.8) in the control group. The plasma vit D levels of the AS patients were significantly lower than those of the patients in the control group (p=0.004). The men in the AS group had significanly lower vit D levels than those in the control group (p=0.005). On the other hand, the women in the uSpA group had significanly lower vit D levels than those in the control group (p=0.011). The vit D levels were inversely related to both erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) in the AS patients (p=0.002, R=-0.428; p<0.001, R=-0.592, respectively). This correlation was not demonstrated in the uSpA patients. The vit D levels were not found to correlate with the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) levels in either the AS or uSpA patients. Conclusion 25-hydroxy-vit D deficiency is frequently observed in patients with SpAs. In this study, vit D deficiency was much more prominent in the male AS patients. On the other hand, among women, the uSpA patients exhibited much more prominent vit D deficiency than the control group subjects. The acute phase response may inversely affect the vit D levels in AS patients.

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“…Despite being the most common periodic fever, the factors triggering and terminating these spells are not completely understood 14 . In several studies, inverse correlation was found between disease activity and serum vitamin D levels in patients with FMF [15][16][17] .…”

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confidence: 99%

Serum vitamin D levels during activation and remission periods of patients with juvenile idiopathic arthritis and familial Mediterranean fever

Dağdeviren-Çakır¹,

Arvas²,

Barut³

et al. 2016

Turk J Pediatr

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The aim of this study was to determine the frequency of vitamin D deficiency and/or insufficiency in children with juvenile idiopathic arthritis (JIA) and familial Mediterranean fever (FMF) and to assess the relationship between vitamin D and disease activity. Sixty four patients with JIA, thirty six patients with FMF and one hundred healthy children were enrolled in this study. Vitamin D levels were measured during activation and remission periods in the patients with JIA and during attack and attack free periods in the patients with FMF. The mean vitamin D levels were found to be 18. 9±11 ng/ml and 18.6±9.2 ng/ml during activation and remission periods of disease, respectively, in the patients with JIA, 16±8.5 ng/ml and 13.1±6.4 ng/ml during attack and attack-free periods, respectively, in the patients with FMF and 26.7±10.5 ng/ml in the healthy children. There was no significant difference between vitamin D levels during activation and remission periods in the patients with JIA, whereas vitamin D levels during attack free periods were lower compared to attack periods in the patients with FMF. No significant relationship was found between disease activity and serum vitamin D levels. The vitamin D levels of the children with JIA and FMF were significantly lower compared to the healthy children. The frequency of vitamin D deficiency and insufficiency was considerably high among the patients with JIA and FMF.

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Low plasma vitamin D levels in patients with familial Mediterranean fever

Cited by 20 publications

References 13 publications

Colchicine resistance and low vitamin D in familial Mediterranean fever

Colchicine resistance and low vitamin D in familial Mediterranean fever

Decreased Plasma Vitamin D Levels in Patients with Undifferentiated Spondyloarthritis and Ankylosing Spondylitis

Serum vitamin D levels during activation and remission periods of patients with juvenile idiopathic arthritis and familial Mediterranean fever

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