Serum vitamin D levels during activation and remission periods of patients with juvenile idiopathic arthritis and familial Mediterranean fever

Dağdeviren-Çakır, Aydilek; Arvas, Ahmet; Barut, Kenan; Gür, Emel; Kasapçopur, Özgür

doi:10.24953/turkjped.2016.02.001

Cited by 24 publications

(40 citation statements)

References 27 publications

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“… Illinois, USA Reed et al 1991 40°N [ 46 ] JRA n = 13 (12F) 5–18 70.0 ± 40 Vitamin D may help prevent bone loss in children with active disease. Study Design: Case-Control Istanbul, Turkey Dagdeviren- Cakir et al 2016 41°N [ 21 ] JIA Active disease: n = 64 (41) Remission: 53(35) Active disease: 9.7 ± 4.3 Remission: 9.8 ± 4.3 Active disease: 46.5 ± 23.0 Remission: 47.3 ± 27.5 Vitamin D concentrations in children with JIA were significantly lower than healthy children. Of those who were measured while in remission there was no difference in 25(OH)D concentrations.…”

Section: Results Of Scoping Review and Discussionmentioning

confidence: 99%

“…Twenty-one of the 38 studies (55.3%) reported 25(OH)D status for patients with JIA [ 21 – 40 ], eight (21.1%) for patients with JRA [ 41 – 48 ] and five (13.2%) for JCA patients [ 49 – 53 ]. Additionally, there were four studies that included patients with juvenile arthritis and other rheumatic diseases [ 54 – 57 ].…”

Section: Results Of Scoping Review and Discussionmentioning

confidence: 99%

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Vitamin D and juvenile idiopathic arthritis

2018

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BackgroundVitamin D has been implicated in the pathogenesis of autoimmune diseases. While the roles of vitamin D in other autoimmune diseases have been investigated, less is known about the role of vitamin D in chronic childhood arthritis.Main bodyThis review summarizes and evaluates evidence relating to 25-hydroxyvitamin D (25(OH)D) and chronic childhood arthritis. A scoping literature review was conducted using Ovid Medline, Ovid Embase, Cumulative Index to Nursing and Allied Health Literature, Web of Science and Scopus. Further, we geo-mapped the results of the studies to identify the patterns of the association between vitamin D and chronic childhood arthritis across the globe. Of 38 studies reporting 25(OH)D concentrations in childhood chronic arthritis, 32 (84.2%) reported that a significant number of children had suboptimal (< 75 nmol/L) status.ConclusionThe data indicate suboptimal vitamin D status in children with chronic arthritis. Further, the association between low vitamin D and increased arthritis activity follow a north-south geographical gradient.

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Section: Results Of Scoping Review and Discussionmentioning

confidence: 99%

Section: Results Of Scoping Review and Discussionmentioning

confidence: 99%

Vitamin D and juvenile idiopathic arthritis

2018

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“…Thus, the JIA treatment should be prompt and effective. The importance of supportive measurements, such as adequate nutrition, calcium and Vitamin D supplements, should not be underestimated (7,45,46). The aim of the therapy should be multidimensional: to control the pain, to preserve the range of motion/muscle strength/muscle function, to induce disease remission, to manage systemic complications and to facilitate normal physical and psychosocial development.…”

Section: Juvenile Idiopathic Arthritis Subtypesmentioning

confidence: 99%

Juvenile Idiopathic Arthritis

et al. 2017

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Juvenile idiopathic arthritis is the most common chronic rheumatic disease of unknown aetiology in childhood and predominantly presents with peripheral arthritis. The disease is divided into several subgroups, according to demographic characteristics, clinical features, treatment modalities and disease prognosis. Systemic juvenile idiopathic arthritis, which is one of the most frequent disease subtypes, is characterized by recurrent fever and rash. Oligoarticular juvenile idiopathic arthritis, common among young female patients, is usually accompanied by anti-nuclear antibodie positivity and anterior uveitis. Seropositive polyarticular juvenile idiopathic arthritis, an analogue of adult rheumatoid arthritis, is seen in less than 10% of paediatric patients. Seronegative polyarticular juvenile idiopathic arthritis, an entity more specific for childhood, appears with widespread large- and small-joint involvement. Enthesitis-related arthritis is a separate disease subtype, characterized by enthesitis and asymmetric lower-extremity arthritis. This disease subtype represents the childhood form of adult spondyloarthropathies, with human leukocyte antigen-B27 positivity and uveitis but commonly without axial skeleton involvement. Juvenile psoriatic arthritis is characterized by a psoriatic rash, accompanied by arthritis, nail pitting and dactylitis. Disease complications can vary from growth retardation and osteoporosis secondary to treatment and disease activity, to life-threatening macrophage activation syndrome with multi-organ insufficiency. With the advent of new therapeutics over the past 15 years, there has been a marked improvement in juvenile idiopathic arthritis treatment and long-term outcome, without any sequelae. The treatment of juvenile idiopathic arthritis patients involves teamwork, including an experienced paediatric rheumatologist, an ophthalmologist, an orthopaedist, a paediatric psychiatrist and a physiotherapist. The primary goals of treatment are to eliminate active disease, to normalize joint function, to preserve normal growth and to prevent long-term joint damage. Timely and aggressive treatment is important to provide early disease control. The first-line treatment includes disease-modifying anti-rheumatic drugs (methotrexate, sulphasalazine, leflunomide) in combination with corticosteroids, used in different dosages and routes (oral, intravenous, intra-articular). Intra-articular application of steroids seems to be an effective treatment modality, especially in monoarthritis. Biological agents should be added in the treatment of unresponsive patients. Anti-tumour necrosis factor agents (etanercept, infliximab, adalimumab), anti-interleukin-1 agents (anakinra, canakinumab), anti- interleukin-6 agents (tocilizumab) and T-cell regulatory agents (abatacept) have been shown to be safe and effective in childhood patients. Recent studies reported sustained reduction in joint damage with even complete clinical improvement in paediatric patients, compared to previous data.

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“…Results: We followed 31 patients (81% female) suffering from JIA with ocular manifestations. Median age at JIA onset in girls was 2.5 (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14) years and in boys 8.6 (1-14.5) years, while girls had median age 4.25 (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14) years at first ocular manifestation and boys 8.25 (4 -13.5) years. All patients were RF negative.…”

Section: Resultsmentioning

confidence: 99%

“…Background: Plenty of studies demonstrated the relationship between vitamin D and Juvenile idiopathic arthritis (JIA) disease activity [1,2] .Others reported no relationship between 25(OH)D and disease activity [3,4] . The main source of vitamin D is endogenous vitamin D synthesis induced by sunlight exposure.…”

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confidence: 99%

Ab0994 vitamin D Status in Children With Jia Depending on the Season

Shevchenko

Khadzhynova

2019

Abstracts Accepted for Publication

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BackgroundPlenty of studies demonstrated the relationship between vitamin D and Juvenile idiopathic arthritis (JIA) disease activity [1,2].Others reported no relationship between 25(OH)D and disease activity [3,4]. The main source of vitamin D is endogenous vitamin D synthesis induced by sunlight exposure.ObjectivesThe aim of this study was to examine the status of vitamin D in children with JIA depending on the peculiarities of the disease and the season.Methods92 patients with JIA were examined. The median age of them was 10,5±1,7 years, from 1,8 to 17,6 years (55 female, 37 male). The serum level of vitamin D was measured through blood test by chemiluminescence method. The relationship between the level of vitamin D and disease activity was analyzed based on juvenile arthritis disease activity score (JADAS27).ResultsThe average level of vitamin D was 22,75±1,97ng/ml (corresponded to an insufficient level). It was not found relationship between the frequency of vitamin D deficiency and gender. Vitamin D status changed throughout the year from lowest value 19,52±1,61 ng/ml (in May) till the greatest value 29,62±2,49 ng/ml (in September). Significantly higher level of vitamin D was in September compared to most months (January, p=0,04; February, p=0,04; March, p=0,01; April, p=0,02; May, p=0,01; October, p=0,03; November, p=0,03; December, p=0,01). The geographical location of Kharkiv (Ukraine) is at 50o latitude. It was proved that UVB radiation above the 33° latitude is not intense enough for the synthesis of vitamin D during the whole year [5]. At the same time there was no significant relationship between the low level of vitamin D in serum and disease activity.ConclusionA decrease of vitamin D status were observed throughout the year. Despite the fact that in September was the highest level of vitamin D, the normal concentration was not reached. Seasons should be taken into account, but patients with JIA need supplementation of vitamin D all around the year.References[1] Szymańska-Kałuża J. Biernacka-ZielińskaM, Stańczyk J, Smolewska E. Vitamin D level in children with juvenile idiopathic arthritis and its correlation with clinical picture of the disease. Reumatologia. 2013;51:271–6. doi: 10.5114/reum.2013.37250.[2] çomak E, Doğan çS, Uslu-gökçeoğlu A, Akbaş H, özdem S. Association between vitamin D deficiency and disease activity in juvenile idiopathic arthritis. Turk J Pediatr. 2014;56:626–631.[3] Dağdeviren-çakır A, Arvas A, Barut K, Gür E, Kasapçopur ö. Serum vitamin D levels during activation and remission periods of patients with juvenile idiopathic arthritis and familial Mediterranean fever. Turk J Pediatr. 2016;58:125–31. doi: 10.24953/turkjped.2016.02.001.[4] Bouaddi I, Rostom S, El Badri D, Hassani A, Chkirate B, Abouqal R, et al. Vitamin D concentrations and disease activity in Moroccan children with juvenile idiopathic arthritis. BMC Musculoskelet Disord. 2014;15:115. doi: 10.1186/1471-2474-15-115.[5] Wacker M, Holick MF. Sunlight and vitamin D: a global perspective for health. Dermatoendocrinol. ...

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Serum vitamin D levels during activation and remission periods of patients with juvenile idiopathic arthritis and familial Mediterranean fever

Cited by 24 publications

References 27 publications

Vitamin D and juvenile idiopathic arthritis

Vitamin D and juvenile idiopathic arthritis

Juvenile Idiopathic Arthritis

Ab0994 vitamin D Status in Children With Jia Depending on the Season

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