Low Plasma Zinc Levels and Immunological Responses to Zinc Supplementation in HIV-Infected Patients with Immunological Discordance after Antiretroviral Therapy

Asdamongkol, Nakhon; Phanachet, Pariya; Sungkanuparph, Somnuek

doi:10.7883/yoken.66.469

Cited by 34 publications

(36 citation statements)

References 32 publications

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“…Asdamongkol et al (23) conducted a study with 31 patients who were considered immune -discordant (defined as CD4 counts below 200 cells / L or lower annual increase of 30% from baseline after receiving 12 months of antiretroviral therapy), finding that the CD4 count increases significantly after administration of 15 mg a zinc supplement. In accordance with the present study in which a significant increase in final CD4, after supplementation of zinc sulphate with a reference value of 20%, established by clinical criteria based on the duration of the intervention, as other authors suggested (13)(14)(15).…”

Section: Discussionmentioning

confidence: 99%

Effect of zinc on immune recovery in HIV patients. Medellín 2013. Randomized controlled trial

Contreras-Martínez¹,

Duque-Molina

Vásquez-Trespalacios³

et al. 2017

CES Med

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Introduction: The human immunodeficiency virus (HIV) infection progressively destroys the immune system and increases the susceptibility to opportunistic infections. The aim of this study was to assess the benefits and safety of zinc supplements at nutritional doses. Methods: A randomized, double-blind, placebo control trial was performed in 40 adult patients that received either zinc sulfate or placebo daily during 12 weeks. The CD4 lymphocytes count was evaluated at the beginning and at the end of the intervention. Furthermore, we evaluated different clinical and epidemiological variables. Results: After the intervention, an increase ≥ 20% in CD4 lymphocytes was compared between groups; better response was observed in patients who received zinc (90% vs. 25%, p = 0.00), RR = 3.6 (95% CI 1.66; 7.8, p = 0.000) and reduction of relative risk of 74% compared to placebo. Conclusion: This clinical trial shows that patients who receive zinc sulfate supplement could increase the CD4 lymphocyte counting.

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Section: Discussionmentioning

confidence: 99%

Effect of zinc on immune recovery in HIV patients. Medellín 2013. Randomized controlled trial

Contreras-Martínez¹,

Duque-Molina

Vásquez-Trespalacios³

et al. 2017

CES Med

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“…In contrast, most of the studies after the initiation of ART used single nutrients such as zinc, selenium, calcium and vitamin D, which have been recognized to be deficient after initiation of ART. 39,67,[88][89][90]102,105,106 The report from Isanaka et al 87 suggests that supplementation with multivitamin at the RDA level is still safe in coadministration with ART, but high doses of vitamins should be avoided. Another study assessed the effect of vitamin supplements on HIV shedding in breast milk in HIV-infected lactating women.…”

Section: Discussionmentioning

confidence: 99%

“…39,67,88,90,102 However, the articles led by Isanaka et al, 87 Austin et al, 86 and Kaiser et al 23 reported the use of multiple combinations of multivitamins.…”

Section: Rcts Of Micronutrients In Plwh Receiving Artmentioning

confidence: 99%

“…In a report from an RCT of zinc supplementation for 6 months, Asdamongkol et al 102 randomized into zinc or placebo supplementation a group of 31 PLWH with immunological discordance (achieving controlled viral load without increasing CD4 cell count .200 cells/μL) and found that CD4 cell counts significantly increased in patients who started the study with low plasma levels of zinc. These findings agreed with those of a much larger study by Baum et al 39 of 231 adults living with HIV, who used illicit drugs, and were zinc deficient at randomization.…”

Section: Rcts Of Micronutrients In Plwh Receiving Artmentioning

confidence: 99%

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Review of randomized controlled trials of nutritional supplementation in people living with HIV

Sneij¹,

Campa²,

Baum³

2016

NDS

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“…Desta forma, estudos avaliaram a relação entre a concentração de zinco no plasma e respostas imunológicas após suplementação do mineral em pacientes HIV positivos. Os resultados mostraram que a contagem de células CD4 foi maior e da carga viral menor nos pacientes que receberam a suplementação com zinco em comparação com aqueles que receberam o placebo (27). No entanto, apesar dos indivíduos do presente estudo apresentarem altas concentrações de zinco no plasma, não se observou relação entre a concentração do mineral e a contagem de linfócitos T CD4 e a carga viral.Além dessas funções, o zinco possui papel na proteção antioxidante das células combatendo as espécies reativas de oxigênio (EROs).…”

unclassified

Evaluation of oxidative status, food consumption of zinc and plasma zinc in HIV-infected individuals

Tonel¹,

Silva²,

Maziero³

et al. 2018

Revista Brasileira De Análises Clínicas

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Artigo Original/Original Article Resumo Objetivo: Objetivou-se analisar o consumo alimentar e os níveis plasmáticos de zinco além de biomarcadores do status oxidativo de pacientes com infecção pelo HIV. Métodos: Foram selecionados indivíduos adultos com HIV e contagem de linfócitos T CD4<500 células/mm 3 , assistidos por um centro especializado, localizado na região oeste do Paraná. Realizou-se a aplicação de questionários, avaliação antropométrica e coleta sanguínea para análise de zinco e biomarcadores do status oxidativo. Resultados: Avaliou-se um total de quarenta indivíduos adultos, nos quais se observaram consumo adequado de zinco e grande frequência de eutrofia e sobrepeso. Obteve-se correlação positiva entre tióis proteicos (SH-P) e os níveis plasmáticos de zinco e correlação negativa entre SH-P e a peroxidação lipídica (PL) no plasma e nos eritrócitos. Além disso, verificou-se um aumento nos níveis de SH-P em pacientes com presença de doença oportunista em alguma fase da infecção viral. Conclusão: Apesar de não ter sido observada relação entre níveis de zinco sanguíneo e a contagem de linfócitos T CD4 e carga viral, as propriedades do mineral ainda são defendidas como essenciais.

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Low Plasma Zinc Levels and Immunological Responses to Zinc Supplementation in HIV-Infected Patients with Immunological Discordance after Antiretroviral Therapy

Cited by 34 publications

References 32 publications

Effect of zinc on immune recovery in HIV patients. Medellín 2013. Randomized controlled trial

Effect of zinc on immune recovery in HIV patients. Medellín 2013. Randomized controlled trial

Review of randomized controlled trials of nutritional supplementation in people living with HIV

Evaluation of oxidative status, food consumption of zinc and plasma zinc in HIV-infected individuals

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