We present dedicated circuit techniques and strategies to design and assemble dense multi-channel microsystems intended for ENG recording. Efficient neural interfacing circuits are proposed and high-fidelity data reduction strategies are demonstrated. Also, an on-chip power management scheme based on automatic biopotential detection is suggested. The presented strategy is expected to improve power consumption in multi-channel ENG sensors by an order of magnitude. Lowpower design techniques, ultra-low-power neural signal processing circuits, and dedicated implementation strategies to achieve high integration density in multi-channel microsystems are also covered.