1990
DOI: 10.1002/jmv.1890320409
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Low prevalence of antibody to hepatitis C virus in North East England

Abstract: The prevalence of antibodies to hepatitis C virus (anti-HCV) was studied in North East England in blood donors, local multiply transfused patients, local high risk individuals, and chronic liver disease patients. Anti-HCV was detected by enzyme-linked immunosorbent assay (ELISA) in 2/1120 (0.18%) blood donors; 1/84 chronic renal failure patients on haemodialysis who had received 1,992 units of blood (seroconversion rate of 0.05% per unit transfused), 1/207 cardiac patients 6 months post cardiac surgery transfu… Show more

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Cited by 29 publications
(10 citation statements)
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“…There was a correlation between the specificity of the RIBA and the EIA optical density (OD) reading; most false positives had OD readings of less than 1.0 (data not shown). These data support the results of other studies [Aceti et al, 1990;Brind et al, 1990;Van der Poel et al, 19901. In HD patients with a history of blood transfusion, anti-HTLV-I was detected in only one (1.0%) of 103 patients dialysed for less than 3 years, and the prevalence of anti-HTLV-I in these patients and controls (0.5%) showed no significant difference. No patients were positive for anti-HIV-1.…”
Section: Discussionsupporting
confidence: 95%
“…There was a correlation between the specificity of the RIBA and the EIA optical density (OD) reading; most false positives had OD readings of less than 1.0 (data not shown). These data support the results of other studies [Aceti et al, 1990;Brind et al, 1990;Van der Poel et al, 19901. In HD patients with a history of blood transfusion, anti-HTLV-I was detected in only one (1.0%) of 103 patients dialysed for less than 3 years, and the prevalence of anti-HTLV-I in these patients and controls (0.5%) showed no significant difference. No patients were positive for anti-HIV-1.…”
Section: Discussionsupporting
confidence: 95%
“…Studies of injecting drug users have found a consistently high prevalence of infection (38%-98% [40][41][42][43][44]. Patients with clotting disorders who received blood products before the introduction of eVective viral inactivation procedures, also have a high prevalence of HCV infection (76%-98% [45][46][47] ).…”
Section: Methods Used To Study Sexual Transmissionmentioning
confidence: 99%
“…especially high-risk transfusion patients such as hemophiliacs, [22][23][24] chronic renal patients, and those patients with recent cardiac surgery. 24 In addition, the agent has been found in U.S. veterans, 2s and implicated in maternal transmission, 11,26 sexual transmission, 12,13,27 and IV-drug abuse. 28'29 The purpose of the present study was to explore the relationships between STDs and current or prior HCV infection and thus identify known STDs as possible markers for HCV.…”
Section: Discussionmentioning
confidence: 99%