Low prevalence of CCR5-Δ32, CCR2-64I and SDF1-3′A alleles in the Baiga and Gond tribes of Central India

Kumar, Ashish; Mahla, Ranjeet Singh; Kumar, Sushil; Ingle, Harshad; Yadav, Tushar; Mishra, Anamika; Raut, Ashwin Ashok; Kumar, Himanshu

doi:10.1186/s40064-015-1238-6

Cited by 11 publications

(4 citation statements)

References 19 publications

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“…In the present study, the frequency of the CCR5Δ32 allele in healthy Turkmen people was not found. This is consistent with other studies from Iran [16,17,46,53,54] and other countries [55][56][57][58][59][60][61][62]. In contrast to our research, Trecarichi et al have shown a significantly higher frequency of Δ32 in the healthy control group compared to HIV-positive people.…”

Section: Discussionsupporting

confidence: 93%

Prevalence of CCR5 Delta 32 Genetic Variant in the Turkmen Population of Golestan Province, Northeast of Iran

Norasi

Rastegar

Hosseini

et al. 2023

BioMed Research International

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The 32 bp deletion in the chemokine receptor (C-C motif) 5 gene (CCR5Δ32) is a natural loss of function polymorphism that prevents the protein from locating on the cell surface. This genetic variation acts as a double-edge sword in the pathogenesis/defense mechanism of different health conditions, such as viral infections, autoimmune diseases, and cancers. Here, we evaluated the prevalence of the CCR5Δ32 polymorphism in the Turkmen population of Golestan province, northeast of Iran. Blood samples were collected from 400 randomly selected Turkmen populations (199 women and 201 men), and genomic DNA was extracted. Characterization of CCR5Δ32 genotypes was performed by PCR using primers flanking the 32-nucleotide deletion in the CCR5 gene. The amplified DNA fragments were visualized on 2% agarose gel electrophoresis with cybergreen staining under UV light. All individuals were of Turkmen ethnicity and lived in the Golestan province, northeast of Iran. The mean age of all participants was 35.46 years, with a 20-45 year range. All the studied subjects were healthy without any severe conditions such as autoimmune disease and viral infections. All individuals had no history of HIV infection. The PCR product visualization showed that all the samples are at the 330 bp size, which means the CCR5Δ32 allele was utterly absent from the study population. The presence of the CCR5Δ32 allele among Turkmens may be attributed to the admixture with European descent people. We conclude that the CCR5Δ32 polymorphism may be absent in the Iranian Turkmen population, and further studies with a large population are needed.

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Section: Discussionsupporting

confidence: 93%

Prevalence of CCR5 Delta 32 Genetic Variant in the Turkmen Population of Golestan Province, Northeast of Iran

Norasi

Rastegar

Hosseini

et al. 2023

BioMed Research International

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“…Numerous studies were reported at the context of disease epidemiology and genetics, upon various indian tribal communities, who are highly isolated both demographically and topogra phically, from the mainstream indian populations [4][5][6][7][8][9][10][11][12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Association of ACE <i>DD</i> Genotype with Hypertension among the Tribal Populations of South India

Paramasivam

Nandakumar

Arumugam

et al. 2016

ILNS

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The Renin-Angiotensin System (RAS) is an important regulator of the blood pressure(BP). The level of the vasoactive peptide Angiotensin-II, is mainly determined by the RAS enzyme, angiotensin converting enzyme-1 (ACE-1). Polymorphisms in ACE gene is reported to be associated with hypertension in various populations worldwide. We investigated the association of ACE I/D polymorphisms with hypertension among the tribal populations of South India. Samples were collected from hypertensive patients (n = 33) and healthy controls (n = 37). Genotyping was performed using Polymerase chain reaction (PCR) with allele specific primers. The DD genotype is significantly observed among the cases (OR = 1.0) . Specifically, the DD genotype is more evident among the females (OR = 0.705) than males (OR = 1.22) and is analysed to be associated with hypertension among the tribal populations of South India.

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“…Among other African populations, frequencies ranging from 10%–30% have been reported. The frequencies of the CCR2-64I allele in African populations have been higher than what has been observed in Caucasians (7%–10%), while Asian populations show a wider range from 1%–30% 22. A study on subjects selected from different regions of Jordan showed that this allele is common among Jordanians, with a prevalence of 17.5% 8.…”

Section: Discussionmentioning

confidence: 88%

<p>CCR2 Genetic Polymorphism And Its Potential Effect On HIV Acquisition In A Population Of Children Living In The Northern Region Of Cameroon</p>

Ngoufack

Nkenfou

Tiedeu

et al. 2019

TACG

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Background and objectivesThe association of chemokine receptor-2 (CCR2) polymorphism with HIV transmission or disease progression remains highly controversial. The role of CCR2-64I allele in HIV infection may differ from one population to another because of their genetic background. The objectives of this study were to characterize the CCR2 genetic polymorphism and to determine its potential effect in HIV acquisition in children living in the Northern Region of Cameroon.Materials and methodsA cross-sectional study was carried out in five health facilities in the Northern region of Cameroon. DNA was extracted from the Buffy coat of each participant using the QIAamp®DNA mini kit. The DNA extract was then subjected to polymorphic analyses. CCR2 genotypes were analyzed by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP). The Chi-Squared test was used for the assessment of the Hardy-Weinberg equilibrium.ResultsA total of 134 children under 15 years comprised of 38 HIV-exposed infected (28.36%) and 96 HIV-exposed un-infected (71.64%) participants were recruited. Prevalences of 44.78% wild type homozygous, 48.52% heterozygous and 6.7% mutant homozygous alleles were found in the overall population. An allelic frequency of 29.69% for the mutant allele CCR2-64I was found in HIV-exposed un-infected individuals as compared to 34.21% in HIV-infected children (p=0.47).ConclusionThe CCR2-64I allele is relatively common in the Northern Region of Cameroon, with a similar distribution among HIV-exposed un-infected and infected children. As this allele alone does not seem to confer protection against HIV-1 infection, further studies using genotype-combination of CCR2 polymorphism and other single nucleotide polymorphisms would be of great relevance in both HIV prevention and novel therapeutic strategies.

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Low prevalence of CCR5-Δ32, CCR2-64I and SDF1-3′A alleles in the Baiga and Gond tribes of Central India

Cited by 11 publications

References 19 publications

Prevalence of CCR5 Delta 32 Genetic Variant in the Turkmen Population of Golestan Province, Northeast of Iran

Prevalence of CCR5 Delta 32 Genetic Variant in the Turkmen Population of Golestan Province, Northeast of Iran

Association of ACE <i>DD</i> Genotype with Hypertension among the Tribal Populations of South India

<p>CCR2 Genetic Polymorphism And Its Potential Effect On HIV Acquisition In A Population Of Children Living In The Northern Region Of Cameroon</p>

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