Low Prevalence of Psychoses Among the Hutterites, an Isolated Religious Community

Nimgaonkar, V.L.; Fujiwara, Takuya; Dutta, Mahendra; Wood, John; Gentry, Kathye A.; Maendel, Selma; Morgan, Kenneth; Eaton, Joseph W.

doi:10.1176/appi.ajp.157.7.1065

Cited by 54 publications

(41 citation statements)

References 18 publications

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“…The Hutterites are an Anabaptist sect, who lives in colonies on North America [Nimgaonkar et al, 2000]. The term ''anabaptist'' comes from the practice of baptizing individuals who had been baptized previously.…”

Section: Discussionmentioning

confidence: 99%

Mutations that impair interaction properties of TRIM32 associated with limb-girdle muscular dystrophy 2H

et al. 2008

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TRIM32 belongs to a large family of proteins characterized by a tripartite motif, possibly involved in the ubiquitination process, acting as an E3 ligase. In addition, TRIM32 has six NHL repeats with putative interaction properties. A homozygous mutation at the third NHL repeat (D487N) has been found in patients with limb girdle muscular dystrophy 2H (LGMD2H). This mutation was only identified in the inbred Manitoba Hutterite or their descendants. Interestingly, a mutation in the B-box domain of TRIM32 cosegregates with Bardet-Biedl syndrome type 11 (BBS11). The signs of BBS11 include obesity, pigmentary and retinal malformations, diabetes, polydactyly, and no muscular dystrophy, suggesting an alternative disease mechanism. We aim to ascertain whether D487N is the only pathological LGMD2H allele, limited to Hutterites. We studied the TRIM32 gene in 310 LGMD patients with no mutations at the other known loci. We identified four patients with novel mutated alleles. Two mutations were homozygous and missing in controls. These mutations also clustered at the NHL domain, suggesting that a specific (interaction) property might be abolished in LGMD2H patients. No mutations were found at the B-box region where the BBS11 mutation is found. We tested TRIM32 and its mutants by yeast-two-hybrid assay, developing an interaction test to validate mutations. All LGMD2H mutants, but not the BBS11, lost their ability to self-interact. The interaction of TRIM32 mutants with E2N, a protein involved in the ubiquitination process, was similarly impaired. In conclusion, the mutations here reported may cause muscular dystrophy by affecting the interaction properties of TRIM32.

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Section: Discussionmentioning

confidence: 99%

Mutations that impair interaction properties of TRIM32 associated with limb-girdle muscular dystrophy 2H

et al. 2008

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“…SZ has a lifetime morbid risk of 1%, although geographic variations in the prevalence are likely (41). The incidence of SZ is 0.53 per 1,000 population approximately (23).…”

Section: Epidemiologymentioning

confidence: 99%

Genetic Association Studies of Antioxidant Pathway Genes and Schizophrenia

Chowdari

Bamne²,

Nimgaonkar³

2011

Antioxidants & Redox Signaling

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The endogenous production of highly reactive oxidation species is an inherent by-product of cellular energy metabolism. Cellular antioxidant defense systems (AODS) comprising various antioxidants counter these damaging effects. Several lines of evidence, including postmortem studies, suggest increased oxidative stress in patients with schizophrenia. Some genetic association studies and gene-expression studies suggest that patients also may have altered ability to mount antioxidative mechanisms. As the genetic associations may provide etiologic evidence in support of the oxidative-stress hypothesis of schizophrenia, a focused review has been conducted. We also suggest avenues for further research. Antioxid. Redox Signal. 15, 2037Signal. 15, -2045

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“…The group with no religious affi liation reveals itself, as verifi ed in the international literature, to be more involved with alcohol use and misuse (Hadaway & Roof, 1979;Hout & Fischer, 2002). Moreover, considering international studies, while it is diffi cult to establish reliable comparisons (because of marked cultural differences) some studies in other communities (Nimgaonkar et al, 2000;Loewenthal et al, 2003) revealed differences in the prevalence of mental disorders and substance misuse between minority ethnic-religious groups (such as Hutterites in Canada and Jews in the UK) and the general population. For the present investigation, some methodological limitations should be considered.…”

Section: Discussionmentioning

confidence: 99%

Religious Affiliation and Psychiatric Morbidity in Brazil: Higher Rates Among Evangelicals and Spiritists

Dalgalarrondo

Marín-León

Botega

et al. 2008

Int J Soc Psychiatry

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Low Prevalence of Psychoses Among the Hutterites, an Isolated Religious Community

Cited by 54 publications

References 18 publications

Mutations that impair interaction properties of TRIM32 associated with limb-girdle muscular dystrophy 2H

Mutations that impair interaction properties of TRIM32 associated with limb-girdle muscular dystrophy 2H

Genetic Association Studies of Antioxidant Pathway Genes and Schizophrenia

Religious Affiliation and Psychiatric Morbidity in Brazil: Higher Rates Among Evangelicals and Spiritists

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