“…While the biology of SSCs and SCs, as well as the entire process of male germ cell development, have been sufficiently studied and covered in many reviews (Griswold, 1998;Griswold, 2018;Hess and Renato de Franca, 2008;Kopera et al, 2010;Kubota and Brinster, 2018;de Rooij, 2017), the development of rete testis and understanding of its role in the functioning of the spermatogenic system are only beginning to gain clarity. Recently, a study (Imura-Kishi et al, 2021) revealed the role of the rete testis in maintaining the regional specialization of the SCs in the terminal sections (transitional zones) of the convoluted seminiferous tubules. Evidence suggests that the terminal sections of the seminiferous tubules are a niche for Gfra1 + SSCs (Aiyama et al, 2015), the site of the prolonged proliferation of SCs in the pubertal and postpubertal testis (Figueiredo et al, 2016(Figueiredo et al, , 2019Malolina and Kulibin, 2017), and the site of spermatogenic wave generation that supports conti-…”