Low <scp>IL</scp>‐8 is associated with anxiety in suicidal patients: genetic variation and decreased protein levels

Janelidze, Shorena; Suchankova, Petra; Ekman, Agneta; Erhardt, Sophie; Sellgren, Carl M.; Samuelsson, Martin; Westrin, Åsa; Minthon, Lennart; Hansson, Oskar; Träskman‐Bendz, Lil; Brundin, Lena

doi:10.1111/acps.12339

Cited by 75 publications

(65 citation statements)

References 59 publications

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“…A previous study had found lower CSF levels of neuroprotective IL-8 levels in suicide attempters compared with healthy controls, confirming dysregulation of the immune system in suicidal patients (Isung et al, 2012). Since then, we found that decreased IL-8 levels were specific to patients with anxiety and identified the presence of a single-nucleotide polymorphism in the promoter region of the IL-8 gene, which predicted more severe anxiety in the suicide attempters (Janelidze et al, 2015). Interestingly, O'Donovan et al (2013) demonstrated that increased inflammation correlated with the degree of suicidal ideation in patients with depression, even after controlling for active suicide attempts and degree of depressive symptoms.…”

Section: Inflammation and Symptoms Of Suicidalitysupporting

confidence: 76%

Role of Inflammation in Suicide: From Mechanisms to Treatment

Brundin

Bryleva

Rajamani

2016

Neuropsychopharmacol

189

137

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Suicidal behavior is complex and manifests because of a confluence of diverse factors. One such factor involves dysregulation of the immune system, which has been linked to the pathophysiology of suicidal behavior. This review will provide a brief description of suicidality and discuss the contribution of upstream and downstream factors in the etiology of suicidal behavior, within the contextual framework of inflammation. The contribution of inflammatory conditions such as traumatic brain injury, autoimmune disorders, and infections to neuropsychiatric symptoms and suicidality is only beginning to be explored. We will summarize studies of inflammation in the etiology of suicide, and provide a neurobiological basis for different mechanisms by which inflammation might contribute to the pathophysiology. Finally, we will review treatments that affect upstream and downstream pathways related to inflammation in suicidality.

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Section: Inflammation and Symptoms Of Suicidalitysupporting

confidence: 76%

Role of Inflammation in Suicide: From Mechanisms to Treatment

Brundin

Bryleva

Rajamani

2016

Neuropsychopharmacol

189

137

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“…Its primary known function is to induce chemotaxis in neutrophils and other granulocytes, causing them to migrate toward the site of infection. Recently, IL8 has been shown to have neuro-protec- tive properties as plasma and CSF levels of IL-8 were significantly lower in suicide attempters with anxiety than in healthy controls (38). IL8 is well known to play a role in the pathogenesis of bronchiolitis but its role in T1D pathogenesis is unclear.…”

Section: Discussionmentioning

confidence: 99%

Large-Scale Discovery and Validation Studies Demonstrate Significant Reductions in Circulating Levels of IL8, IL-1Ra, MCP-1, and MIP-1β in Patients With Type 1 Diabetes

Purohit

Sharma

Hopkins

et al. 2015

The Journal of Clinical Endocrinology & Metabolism

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“…Manual bibliography search did not reveal any additional articles. Four articles were excluded due to overlapping samples (Grudet et al, 2014; Isung et al, 2014; Janelidze et al, 2015; Lee and Kim, 2010). …”

Section: Methodsmentioning

confidence: 99%

The role of cytokines in the pathophysiology of suicidal behavior

Ganança

Oquendo

Tyrka

et al. 2016

Psychoneuroendocrinology

186

128

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Objective Immune dysregulation has been implicated in depression and other psychiatric disorders. What is less clear is how immune dysregulation can affect risk of suicidal behavior. We reviewed the scientific literature concerning cytokines related to suicidal ideation, suicidal behavior and suicide, and surveyed clinical and neurobiological factors associated with cytokine levels that may modulate effects of inflammation on suicide risk. Methods We searched PubMed, Embase, Scopus and PsycINFO for relevant studies published from 1980 through February, 2015. Papers were included if they were written in English and focused on cytokine measurements in patients with suicidal behaviors. Results The literature search yielded 22 studies concerning cytokines and suicidal ideation, suicide attempts or suicide completion. The most consistent finding was elevated interleukin (IL)-6, found in 8 out of 14 studies, in CSF, blood, and postmortem brain. In one study, IL-6 in CSF was also found to be higher in violent than nonviolent attempters and to correlate with future suicide completion. Low plasma IL-2 was observed in 2 studies of suicide attempters, while divergent results were seen for tumor necrosis factor (TNF)-α, interferon (IFN)-γ, transforming growth factor (TGF)-β, IL-4, and soluble Il-2 receptors. Conclusions Given the complexity suggested by the heterogenous cytokine findings, putative mediators and moderators of inflammation on suicidal behavior merit further study. Elevated IL-6 was the most robust cytokine finding, associated with suicidal ideation and both nonfatal suicide attempts and suicides. Future studies should evaluate the predictive value of high IL-6, consider how this may alter brain function to impact suicidal behavior, and explore the potential beneficial effects of reducing IL-6 on suicide risk.

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Low IL‐8 is associated with anxiety in suicidal patients: genetic variation and decreased protein levels

Abstract: We suggest that IL-8 might be involved in the biological mechanisms mediating resilience to anxiety. Thus, our findings highlight the chemokine IL-8 as a potential target for future development of anti-anxiety treatments and suicide prevention.

Cited by 75 publications

References 59 publications

Role of Inflammation in Suicide: From Mechanisms to Treatment

Role of Inflammation in Suicide: From Mechanisms to Treatment

Large-Scale Discovery and Validation Studies Demonstrate Significant Reductions in Circulating Levels of IL8, IL-1Ra, MCP-1, and MIP-1β in Patients With Type 1 Diabetes

The role of cytokines in the pathophysiology of suicidal behavior

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