Low serum 25(OH)D levels are assocıated to hıgher BMI and metabolic syndrome parameters in adult subjects in Turkey

Abstract

Background: The aim of this study was to investigate the association of 25(OH)D levels with biochemical, anthropometric, and metabolic data obtained from normal and obese people. Methods: This study was carried out on 90 individuals between the ages of 18 to 63 that had various body mass indexes. Blood samples and anthropometric measurements were taken. Results: Waist circumferences, fat mass, LDL cholesterol levels, HDL cholesterol levels, 25(OH)D levels, and triglyceride levels were significantly different according to the body mass index groups of the participants (p<0.05). When compared to the normal body mass index group, both other groups (overweight and obese) had higher waist circumferences, triglyceride levels, LDL cholesterol levels, fasting insulin levels, HOMA-IR ratios, parathyroid hormone levels, and fat mass, and had lower 25(OH)D levels (p<0.05). The overweight group participants had higher 25(OH)D levels than the obese group, and had lower waist circumferences, fat mass, fasting insulin level, HOMA-IR ratios, and HbA1C and PTH levels than those in the obese group (p<0.05). Conclusion: In conclusion, the mean level of 25(OH)D is very low in overweight and obese individuals and low serum 25(OH)D levels appear to be associated with obesity, visceral obesity, hypertriglyceridemia, insulin resistance, and metabolic syndrome in obese patients.

The Frequency of Vitamin D Deficiency in Obese Patients on Bariatric Surgery Wait List: Is there any Association with Co-existence of Prediabetes or Diabetes?

“…One study including subjects in Korea also showed a negative relation between 25(OH)D3 levels and IR (22). These findings were confirmed by other reports (23). Chiui et al showed decreased first and second phase insulin secretion response in vitamin D-deficient subjects (10).…”

“…However, some reports have shown that BMI was not different in different vitamin D subgroups (36). Central adiposity is also an important contributor to this association (15,23). We found a higher mean vitamin D level in the insulin-resistant group.…”

“…We found a higher mean vitamin D level in the insulin-resistant group. Although obesity was found as a risk factor in vitamin D deficiency (23,24,34,37,38), our findings might suggest that the possible effects of the factors other than IR. However, in our study, neither IR nor BMI were found as predictors for severe vitamin D deficiency.…”

“…The authors demonstrated a negative correlation between vitamin D3 levels and BMI (33). Other studies have also shown this negative correlation (23,24,34), and this correlation was seen both in summer and winter (31). An analysis showed that each 1 kg/m 2 increase in BMI was associated with 1.15% decrease in vitamin D3 levels (35).…”

Decreased adiponectin level in adults with central obesity and low 25-hydroxy vitamin D level

“…This is in line with the results of the study by Johnson et al (20) who reported that subjects with obesity had low levels of vitamin D, particularly in the males compared with the females, with an odds ratio of 1.41 (95% CI: 1.17-1.70). Other studies that showed low levels of vitamin D in subjects with obesity were among others the studies conducted by Shafinaz et al, (18) Oommen et al, (21) and Tosunbayraktar et al (22) In our study we found a mean adiponectin level of 4.7 ± 0.26 ng/mL in subjects with central obesity, which was significantly lower than the mean adiponectin level of 6.8 ± 0.72 ng/mL in the control group. This showed that subjects with central obesity had lower adiponectin levels compared with the controls.…”