Low serum lathosterol levels associate with fatal cardiovascular disease and excess all-cause mortality: a prospective cohort study

Weingärtner, Oliver; Lütjohann, Dieter; Meyer, Sven; Fuhrmann, Arne; Cremers, Bodo; Seiler-Mußler, Sarah; Schött, Hans-F.; Kerksiek, Anja; Friedrichs, Silvia; Ulbricht, Ursula; Zawada, Adam M.; Laufs, Ulrich; Schulze, P. Christian; Scheller, Bruno; Fliser, Danilo; Böhm, Michael; Sijbrands, Eric; Heine, Gunnar H.

doi:10.1007/s00392-019-01474-2

Cited by 13 publications

(12 citation statements)

References 16 publications

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“…Most studies suggest that low TC is associated with a higher risk of death in older adult patients (32)(33)(34)(35). Low TC levels represent deterioration of nutritional status and exacerbated inflammation in older adult patients (32,36,37).…”

Section: Discussionmentioning

confidence: 99%

Controlling Nutritional Status Score as a Predictive Marker of In-hospital Mortality in Older Adult Patients

et al. 2021

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The controlling nutritional status (CONUT) score assesses nutritional status and is associated with short- and long-term prognoses in some diseases, but the significance of the CONUT score for the prediction of in-hospital mortality in older adults is unknown. The purpose was to determine the importance of the CONUT score for the prediction of in-hospital mortality, short-term complications, length of hospital stay, and hospital costs in older adults. Our retrospective cohort study analyzed data from 11,795 older adult patients from two multicenter cohort studies. We performed receiver operating characteristic curve analysis using in-hospital mortality as the endpoint and determined the appropriate CONUT score cut-off by the Youden index. The patients were divided into two high and low groups according to the CONUT cut-off value, and the differences in clinical characteristics and in-hospital clinical outcomes between the two groups were compared. We compared the accuracy of the CONUT score and other nutrition-related tools in predicting in-hospital mortality by calculating the area under the receiver operating characteristic curve and performed univariate and multivariate analyses of predictors of in-hospital mortality. Among all the patients, 178 (1.5%) patients experienced in-hospital death. The optimal cut-off values was 5.5 for the CONUT score. The high CONUT group had a higher incidence of short-term complications and prolonged hospital stay than the low CONUT group (CONUT score <6), but hospital costs were not significantly higher. The CONUT score had the highest predictive ability for in-hospital mortality among the five nutrition-related parameters compared. Multivariate analysis showed that a high CONUT score (CONUT score ≥ 6) was an independent predictor of in-hospital mortality. In conclusion, the present study demonstrated that the CONUT score could be used to predict in-hospital mortality in older adults.

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Section: Discussionmentioning

confidence: 99%

Controlling Nutritional Status Score as a Predictive Marker of In-hospital Mortality in Older Adult Patients

et al. 2021

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“…Recently, a study reported that a low serum lathosterol is correlated with an increased risk for cardiovascular events and an excess of all-cause mortality across 4.9 years of follow-up. None of the other cholesterol homeostasis markers demonstrated this relationship [33]. Various factors may account for the variability in the above studies, such as study design and selection bias, diverse participants in age, health, and genetic background, individual lipoprotein profile, gut microbiome, and variable experimental methods to measure concentration of plant sterols.…”

Section: Discussionmentioning

confidence: 94%

Associations between Circulating Markers of Cholesterol Homeostasis and Macrovascular Events among Patients Undergoing Hemodialysis

et al. 2021

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Current strategies targeting serum cholesterol bring limited benefits to mortality and macrovascular events prevention among hemodialysis patients. Direct measurements and analysis on circulating markers of cholesterol homeostasis could be promising solutions to this bottleneck. We prospectively enrolled 90 maintenance hemodialysis patients and 9 healthy controls in 2019 for 1 year. We measured circulating desmosterol and lathosterol as markers for cholesterol synthesis and campesterol and sitosterol for cholesterol absorption. At baseline, hemodialysis patients showed higher levels of campesterol (p = 0.023) compared to healthy controls. During follow-up, we identified 14 (15.4%) patients who experienced macrovascular events. Comparisons of cholesterol homeostasis markers between cohorts with and without macrovascular events showed no significant differences in markers of cholesterol synthesis or absorption. Using logistic regression analysis, the odds ratio was not statistically significant for the prediction of macrovascular events after full-adjusting for age, sex, diabetes, serum albumin, cholesterol, and triglyceride. We concluded that hemodialysis patients demonstrated higher level of cholesterols absorption, indicated by circulating campesterol compared to healthy subjects. Markers for cholesterol homeostasis were not significantly associated with macrovascular events during a 1-year follow-up. Our results shed light on the novel therapeutic target of modulating cholesterol absorption in HD patients.

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“…Lathosterol indicates the endogenous cholesterol synthesis rate. Low serum lathosterol level could indicate likely a bad prognosis in many diseases [10]. Lipid compounds are important for proper function of the brain [11].…”

Section: Discussionmentioning

confidence: 99%

Serum metabolic profiles changes observed post COVID-19 – Case report

Toczyłowska¹,

Słowikowska²,

Ziemińska³

2021

J Clin Images Med Case Rep

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COVID-19 and its consequences are still not well known. The recovery from the infection is slow and many symptoms persist for a long time. We present the influence of the SARS-CoV-2 infection on serum metabolic profiles. The profiles were obtained using NMR spectroscopy from sera collected two years prior to the infection and twice during the recovery time from otherwise healthy subject. We performed comparisons of data collected pre- with postinfection. We present the metabolites which levels were decreased after COVID-19. These metabolites are involved in metabolic pathways like the TCA cycle, purine, glycine, arginine, proline, pyruvate, taurine, alanine, glutamate, glycerophospholipids, and cholesterol metabolism, as well as fatty acid and steroid hormone biosynthesis. Studies show changes in metabolic profiles during the recovery after COVID-19 that have not been observed by standard blood tests. Keywords: COVID-19; NMR spectroscopy; serum metabolite profiles.

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Low serum lathosterol levels associate with fatal cardiovascular disease and excess all-cause mortality: a prospective cohort study

Cited by 13 publications

References 16 publications

Controlling Nutritional Status Score as a Predictive Marker of In-hospital Mortality in Older Adult Patients

Controlling Nutritional Status Score as a Predictive Marker of In-hospital Mortality in Older Adult Patients

Associations between Circulating Markers of Cholesterol Homeostasis and Macrovascular Events among Patients Undergoing Hemodialysis

Serum metabolic profiles changes observed post COVID-19 – Case report

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